CYB5A cytochrome b5 type A [Bos taurus (cattle)] - Gene

Summary

Official Symbol: CYB5Aprovided by VGNC
Official Full Name: cytochrome b5 type Aprovided by VGNC
Primary source: VGNC:VGNC:50260
See related: Ensembl:ENSBTAG00000012012
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as: CYB5
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 24

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2023_09	current	ARS-UCD2.0 (GCF_002263795.3)	24	NC_037351.1 (4141580..4175483)

Chromosome 24 - NC_037351.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037351.1 Chromosome 24 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

the conserved Tyr30 in Cyt b5 is not replaceable due to the presence of both the H-bond network and hydrophobic interaction in the secondary sphere of the heme active site.
Title: Stabilization of cytochrome b(5) by a conserved tyrosine in the secondary sphere of heme active site: A spectroscopic and computational study.
The study computes electron transfer rates for the [myoglobin(wt), cytochrome b5] complex.
Title: Interfacial hydration, dynamics and electron transfer: multi-scale ET modeling of the transient [myoglobin, cytochrome b5] complex.
The solution structure of the oxidized cytochrome b(5) mutant V61H.
Title: The solution structure of the oxidized bovine microsomal cytochrome b(5) mutant V61H.
Results from three combined experiments demonstrate that the conserved negatively charged region of cytb5 surrounding the solvent-exposed heme edge is involved in the binding interaction with horse heart cytochrome c.
Title: Mapping the binding interface of the cytochrome b5-cytochrome c complex by nuclear magnetic resonance.
the effects on the heme microenvironment of cytochrome b(5) caused by the mutation from Val45 to Tyr45, His45 and Glu45
Title: 1H NMR studies of the effect of mutation at Valine45 on heme microenvironment of cytochrome b5.
From a series of site-directed mutations on Cyt b5 this report assesses the contributions of amino acid residues that are expected to influence the docking and electron transfer (ET) between Cyt b5 and horse heart Cyt c.
Title: Mapping the electron transfer interface between cytochrome b5 and cytochrome c.
simulations provided qualitative microscopic explanations of many of the differences in physical properties between outer mitochondrial membrane CYB5 isoform and microsomal CYB5 and two mutants in terms of localized changes in structure and flexibility
Title: Influence of point mutations on the flexibility of cytochrome b5: molecular dynamics simulations of holoproteins.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables heme binding	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in intracellular membrane-bounded organelle	IEA Inferred from Electronic Annotation more info	PubMed
located_in mitochondrial outer membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: cytochrome b5

Names: cytochrome b-5; cytochrome b5 type A (microsomal)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.