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MAST2 microtubule associated serine/threonine kinase 2 [ Homo sapiens (human) ]

Gene ID: 23139, updated on 8-May-2016
Official Symbol
MAST2provided by HGNC
Official Full Name
microtubule associated serine/threonine kinase 2provided by HGNC
Primary source
HGNC:HGNC:19035
See related
Ensembl:ENSG00000086015 HPRD:11294; MIM:612257; Vega:OTTHUMG00000008007
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MTSSK; MAST205
Orthologs
Location:
1p34.1
Exon count:
37
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 1 NC_000001.11 (45786992..46036124)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (46269269..46501796)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105378693 Neighboring gene ribosomal protein L6 pseudogene 1 Neighboring gene uncharacterized LOC105378694 Neighboring gene translation machinery associated 16 homolog pseudogene 2 Neighboring gene phosphoinositide-3-kinase regulatory subunit 3 Neighboring gene uncharacterized LOC101929626 Neighboring gene uncharacterized LOC105378695 Neighboring gene tetraspanin 1

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ39200, KIAA0807

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding ISS
Inferred from Sequence or Structural Similarity
more info
 
magnesium ion binding ISS
Inferred from Sequence or Structural Similarity
more info
 
microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
 
phosphatase binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
 
intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 
peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
 
protein phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of interleukin-12 biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
spermatid differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
 
microtubule cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
microtubule-associated serine/threonine-protein kinase 2
Names
microtubule associated testis specific serine/threonine protein kinase
NP_055927.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001319245.1NP_001306174.1  microtubule-associated serine/threonine-protein kinase 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AB047005, AL358075, AL603882, BC065499, BM675011
    UniProtKB/Swiss-Prot
    Q6P0Q8
    Conserved Domains (4) summary
    pfam08926
    Location:201476
    DUF1908; Domain of unknown function (DUF1908)
    smart00220
    Location:512785
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd00992
    Location:11051186
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd05609
    Location:511790
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
  2. NM_001324320.1NP_001311249.1  microtubule-associated serine/threonine-protein kinase 2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL358075, AL603882, AL603888, AL645480
  3. NM_001324321.1NP_001311250.1  microtubule-associated serine/threonine-protein kinase 2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL358075, AL603888, AL645480
  4. NM_015112.2NP_055927.2  microtubule-associated serine/threonine-protein kinase 2 isoform 1

    See identical proteins and their annotated locations for NP_055927.2

    Status: VALIDATED

    Source sequence(s)
    AB047005, AL540100, AL603882, BC065499, BM675011, CN297081
    Consensus CDS
    CCDS41326.1
    UniProtKB/Swiss-Prot
    Q6P0Q8
    Related
    ENSP00000354671, OTTHUMP00000009697, ENST00000361297, OTTHUMT00000021977
    Conserved Domains (4) summary
    pfam08926
    Location:201476
    DUF1908; Domain of unknown function (DUF1908)
    smart00220
    Location:512785
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd00992
    Location:11051186
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd05609
    Location:511790
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p2 Primary Assembly

    Range
    45786992..46036124
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011541065.1XP_011539367.1  

    Conserved Domains (4) summary
    pfam08926
    Location:127409
    DUF1908; Domain of unknown function (DUF1908)
    smart00220
    Location:445718
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd00992
    Location:10381119
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd05609
    Location:444723
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
  2. XM_011541059.1XP_011539361.1  

    Conserved Domains (4) summary
    pfam08926
    Location:266548
    DUF1908; Domain of unknown function (DUF1908)
    smart00220
    Location:584857
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd00992
    Location:11771258
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd05609
    Location:583862
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
  3. XM_011541061.1XP_011539363.1  

    Conserved Domains (4) summary
    pfam08926
    Location:266548
    DUF1908; Domain of unknown function (DUF1908)
    smart00220
    Location:584857
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd00992
    Location:11771258
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd05609
    Location:583862
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
  4. XM_011541062.1XP_011539364.1  

    Conserved Domains (4) summary
    pfam08926
    Location:266541
    DUF1908; Domain of unknown function (DUF1908)
    smart00220
    Location:577850
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd00992
    Location:11701251
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd05609
    Location:576855
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
  5. XM_005270652.3XP_005270709.1  

    Conserved Domains (4) summary
    pfam08926
    Location:201483
    DUF1908; Domain of unknown function (DUF1908)
    smart00220
    Location:519792
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd00992
    Location:11121193
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd05609
    Location:518797
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
  6. XM_005270654.2XP_005270711.1  

    Conserved Domains (4) summary
    pfam08926
    Location:201476
    DUF1908; Domain of unknown function (DUF1908)
    smart00220
    Location:512785
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd00992
    Location:11051186
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd05609
    Location:511790
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
  7. XM_011541060.1XP_011539362.1  

    Conserved Domains (4) summary
    pfam08926
    Location:265547
    DUF1908; Domain of unknown function (DUF1908)
    smart00220
    Location:583856
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd00992
    Location:11761257
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd05609
    Location:582861
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
  8. XM_006710475.2XP_006710538.1  

    Conserved Domains (4) summary
    pfam08926
    Location:200482
    DUF1908; Domain of unknown function (DUF1908)
    smart00220
    Location:518791
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd00992
    Location:11111192
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd05609
    Location:517796
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
  9. XM_011541069.1XP_011539371.1  

    Conserved Domains (4) summary
    pfam08926
    Location:266548
    DUF1908; Domain of unknown function (DUF1908)
    smart00220
    Location:584857
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd00992
    Location:11771258
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd05609
    Location:583862
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
  10. XM_011541064.1XP_011539366.1  

    Conserved Domains (4) summary
    pfam08926
    Location:213495
    DUF1908; Domain of unknown function (DUF1908)
    smart00220
    Location:531804
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd00992
    Location:11241205
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd05609
    Location:530809
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
  11. XM_011541063.1XP_011539365.1  

    Conserved Domains (4) summary
    pfam08926
    Location:216498
    DUF1908; Domain of unknown function (DUF1908)
    smart00220
    Location:534807
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd00992
    Location:11271208
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd05609
    Location:533812
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
  12. XM_005270656.3XP_005270713.1  

    Conserved Domains (4) summary
    pfam08926
    Location:107389
    DUF1908; Domain of unknown function (DUF1908)
    smart00220
    Location:425698
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd00992
    Location:10181099
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd05609
    Location:424703
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
  13. XM_005270655.3XP_005270712.1  

    Conserved Domains (4) summary
    pfam08926
    Location:116398
    DUF1908; Domain of unknown function (DUF1908)
    smart00220
    Location:434707
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd00992
    Location:10271108
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd05609
    Location:433712
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
  14. XM_006710477.2XP_006710540.1  

    Conserved Domains (4) summary
    pfam08926
    Location:51333
    DUF1908; Domain of unknown function (DUF1908)
    smart00220
    Location:369642
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd00992
    Location:9621043
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd05609
    Location:368647
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
  15. XM_011541066.1XP_011539368.1  

    Conserved Domains (4) summary
    pfam08926
    Location:40322
    DUF1908; Domain of unknown function (DUF1908)
    smart00220
    Location:358631
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd00992
    Location:9511032
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd05609
    Location:357636
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
  16. XM_011541068.1XP_011539370.1  

    Conserved Domains (4) summary
    pfam08926
    Location:39314
    DUF1908; Domain of unknown function (DUF1908)
    smart00220
    Location:350623
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd00992
    Location:9431024
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd05609
    Location:349628
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
  17. XM_011541067.1XP_011539369.1  

    Conserved Domains (4) summary
    pfam08926
    Location:39321
    DUF1908; Domain of unknown function (DUF1908)
    smart00220
    Location:357630
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd00992
    Location:9501031
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd05609
    Location:356635
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase

Alternate CHM1_1.1

Genomic

  1. NC_018912.2 Alternate CHM1_1.1

    Range
    46386848..46618962
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)