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Zng1 Zn regulated GTPase metalloprotein activator 1 [ Mus musculus (house mouse) ]

Gene ID: 226043, updated on 5-Mar-2024

Summary

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Official Symbol
Zng1provided by MGI
Official Full Name
Zn regulated GTPase metalloprotein activator 1provided by MGI
Primary source
MGI:MGI:2385089
See related
Ensembl:ENSMUSG00000024878 AllianceGenome:MGI:2385089
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cbwd1
Summary
Predicted to enable ATP binding activity. Predicted to be active in cytoplasm. Is expressed in vibrissa. Orthologous to several human genes including CBWD1 (COBW domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in placenta adult (RPKM 5.2), CNS E11.5 (RPKM 4.6) and 20 other tissues See more
Orthologs
human all
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Genomic context

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Location:
19 B; 19 19.86 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (24897280..24939024, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (24919629..24961663, complement)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene cytochrome c, somatic pseudogene Neighboring gene forkhead box D4 Neighboring gene STARR-seq mESC enhancer starr_45808 Neighboring gene microRNA 3084-1 Neighboring gene STARR-positive B cell enhancer mm9_chr19:25033055-25033356 Neighboring gene STARR-positive B cell enhancer ABC_E7639 Neighboring gene STARR-positive B cell enhancer ABC_E5693 Neighboring gene STARR-seq mESC enhancer starr_45809 Neighboring gene dedicator of cytokinesis 8 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:25126893-25127076 Neighboring gene NADH:ubiquinone oxidoreductase subunit B4B Neighboring gene STARR-positive B cell enhancer ABC_E1974 Neighboring gene predicted gene, 34235

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Deletion in the Cobalamin Synthetase W Domain-Containing Protein 1 Gene Is associated with Congenital Anomalies of the Kidney and Urinary Tract. Kanda S, et al. J Am Soc Nephrol, 2020 Jan. PMID 31862704, Free PMC Article
  2. Zn-regulated GTPase metalloprotein activator 1 modulates vertebrate zinc homeostasis. Weiss A, et al. Cell, 2022 Jun 9. PMID 35584702, Free PMC Article
  3. Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function. Zhang T, et al. Sci Rep, 2017 Apr 5. PMID 28378742, Free PMC Article
  4. The central role of EED in the orchestration of polycomb group complexes. Cao Q, et al. Nat Commun, 2014. PMID 24457600, Free PMC Article
  5. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC28027, MGC59411

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc chaperone activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in intracellular zinc ion homeostasis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in kidney development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein maturation IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
zinc-regulated GTPase metalloprotein activator 1
Names
COBW domain containing 1
COBW domain-containing protein 1
cobalamin synthase W domain-containing protein 1
cobalamin synthetase W domain-containing protein 1
dopamine responsive protein
NP_666209.1
XP_030106750.1
XP_030106751.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_146097.3 → NP_666209.1  zinc-regulated GTPase metalloprotein activator 1

    See identical proteins and their annotated locations for NP_666209.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the functional protein.
    Source sequence(s)
    AC123930, AC139711, AK132291
    Consensus CDS
    CCDS37942.1
    UniProtKB/Swiss-Prot
    Q7TSA8, Q8K399, Q8VEH6
    Related
    ENSMUSP00000025815.9, ENSMUST00000025815.10
    Conserved Domains (3) summary
    COG0523
    Location:40 → 376
    YejR; GTPase, G3E family [General function prediction only]
    pfam07683
    Location:271 → 374
    CobW_C; Cobalamin synthesis protein cobW C-terminal domain
    cl21455
    Location:41 → 205
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RNA

  1. NR_033744.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate 5' splice site, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC123930, AC139711

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    24897280..24939024 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030250890.2 → XP_030106750.1  zinc-regulated GTPase metalloprotein activator 1 isoform X1

    Conserved Domains (1) summary
    COG0523
    Location:1 → 180
    YejR; GTPase, G3E family [General function prediction only]

  2. XM_030250891.2 → XP_030106751.1  zinc-regulated GTPase metalloprotein activator 1 isoform X1

    Conserved Domains (1) summary
    COG0523
    Location:1 → 180
    YejR; GTPase, G3E family [General function prediction only]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8VEH6.1 GenPept UniProtKB/Swiss-Prot:Q8VEH6

Gene LinkOut

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