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Ntrk2 neurotrophic tyrosine kinase, receptor, type 2 [ Mus musculus (house mouse) ]

Gene ID: 18212, updated on 22-May-2016
Official Symbol
Ntrk2provided by MGI
Official Full Name
neurotrophic tyrosine kinase, receptor, type 2provided by MGI
Primary source
MGI:MGI:97384
See related
Ensembl:ENSMUSG00000055254
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tkrb; trkB; trk-B; GP145-TrkB/GP95-TrkB
Orthologs
Location:
13 B1-B2; 13 31.2 cM
Exon count:
23
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 13 NC_000079.6 (58806569..59133970)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 13 NC_000079.5 (58907957..59231337)

Chromosome 13 - NC_000079.6Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930455J16 gene Neighboring gene ribosomal protein L13, pseudogene 2 Neighboring gene predicted gene, 40968 Neighboring gene predicted gene, 40969 Neighboring gene predicted gene, 34245 Neighboring gene predicted gene, 34307 Neighboring gene predicted gene, 34354 Neighboring gene predicted gene, 40970

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Alcoholism, organism-specific biosystem (from KEGG)
    Alcoholism, organism-specific biosystemAlcoholism, also called dependence on alcohol (ethanol), is a chronic relapsing disorder that is progressive and has serious detrimental health outcomes. As one of the primary mediators of the reward...
  • Alcoholism, conserved biosystem (from KEGG)
    Alcoholism, conserved biosystemAlcoholism, also called dependence on alcohol (ethanol), is a chronic relapsing disorder that is progressive and has serious detrimental health outcomes. As one of the primary mediators of the reward...
  • MAPK signaling pathway, organism-specific biosystem (from KEGG)
    MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
  • MAPK signaling pathway, conserved biosystem (from KEGG)
    MAPK signaling pathway, conserved biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
  • Neurotrophin signaling pathway, organism-specific biosystem (from KEGG)
    Neurotrophin signaling pathway, organism-specific biosystemNeurotrophins are a family of trophic factors involved in differentiation and survival of neural cells. The neurotrophin family consists of nerve growth factor (NGF), brain derived neurotrophic facto...
  • Neurotrophin signaling pathway, conserved biosystem (from KEGG)
    Neurotrophin signaling pathway, conserved biosystemNeurotrophins are a family of trophic factors involved in differentiation and survival of neural cells. The neurotrophin family consists of nerve growth factor (NGF), brain derived neurotrophic facto...
  • XPodNet - protein-protein interactions in the podocyte expanded by STRING, organism-specific biosystem (from WikiPathways)
    XPodNet - protein-protein interactions in the podocyte expanded by STRING, organism-specific biosystemXPodNet is a larger version of PodNet. Interactions from STRING database have been added to PodNet to build XPodNet. Hence, not all interactions found in XPodNet do necessarily have to be curated.
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • C030027L06Rik

Gene Ontology Provided by MGI

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
brain-derived neurotrophic factor binding IDA
Inferred from Direct Assay
more info
PubMed 
brain-derived neurotrophic factor binding ISO
Inferred from Sequence Orthology
more info
 
brain-derived neurotrophic factor-activated receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
brain-derived neurotrophic factor-activated receptor activity ISO
Inferred from Sequence Orthology
more info
 
kinase activity IEA
Inferred from Electronic Annotation
more info
 
neurotrophin binding IDA
Inferred from Direct Assay
more info
PubMed 
neurotrophin binding ISO
Inferred from Sequence Orthology
more info
 
neurotrophin receptor activity ISO
Inferred from Sequence Orthology
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
receptor tyrosine kinase binding ISO
Inferred from Sequence Orthology
more info
 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
transmembrane receptor protein tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
brain-derived neurotrophic factor receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
brain-derived neurotrophic factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
calcium-mediated signaling using intracellular calcium source IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell differentiation IEA
Inferred from Electronic Annotation
more info
 
cellular response to amino acid stimulus IDA
Inferred from Direct Assay
more info
PubMed 
central nervous system neuron development IMP
Inferred from Mutant Phenotype
more info
PubMed 
cerebral cortex development IMP
Inferred from Mutant Phenotype
more info
PubMed 
feeding behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
glutamate secretion IPI
Inferred from Physical Interaction
more info
PubMed 
learning IMP
Inferred from Mutant Phenotype
more info
PubMed 
long-term memory ISO
Inferred from Sequence Orthology
more info
 
long-term synaptic potentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
mechanoreceptor differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
negative regulation of anoikis IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
 
nervous system development IEA
Inferred from Electronic Annotation
more info
 
neuromuscular junction development IMP
Inferred from Mutant Phenotype
more info
PubMed 
neuron differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
neuron migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
oligodendrocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
peripheral nervous system neuron development IMP
Inferred from Mutant Phenotype
more info
PubMed 
phosphorylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
positive regulation of axonogenesis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of glucocorticoid receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
positive regulation of neuron projection development IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of peptidyl-serine phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of phosphatidylinositol 3-kinase signaling ISO
Inferred from Sequence Orthology
more info
 
positive regulation of synapse assembly IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of synaptic transmission, glutamatergic ISO
Inferred from Sequence Orthology
more info
 
protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
 
protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
regulation of GTPase activity IDA
Inferred from Direct Assay
more info
PubMed 
regulation of MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
regulation of dendrite development ISO
Inferred from Sequence Orthology
more info
 
regulation of metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of neurotransmitter secretion ISO
Inferred from Sequence Orthology
more info
 
regulation of protein kinase B signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
retina development in camera-type eye IMP
Inferred from Mutant Phenotype
more info
PubMed 
retinal rod cell development IMP
Inferred from Mutant Phenotype
more info
PubMed 
transmembrane receptor protein tyrosine kinase signaling pathway IEA
Inferred from Electronic Annotation
more info
 
vasculogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
axon ISO
Inferred from Sequence Orthology
more info
 
axon terminus ISO
Inferred from Sequence Orthology
more info
 
cell surface ISO
Inferred from Sequence Orthology
more info
 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
dendrite ISO
Inferred from Sequence Orthology
more info
 
dendritic spine ISO
Inferred from Sequence Orthology
more info
 
endosome IDA
Inferred from Direct Assay
more info
PubMed 
excitatory synapse ISO
Inferred from Sequence Orthology
more info
 
growth cone ISO
Inferred from Sequence Orthology
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
neuronal postsynaptic density IDA
Inferred from Direct Assay
more info
PubMed 
perikaryon ISO
Inferred from Sequence Orthology
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
postsynaptic density ISO
Inferred from Sequence Orthology
more info
 
postsynaptic membrane IDA
Inferred from Direct Assay
more info
PubMed 
presynaptic active zone ISO
Inferred from Sequence Orthology
more info
 
receptor complex ISO
Inferred from Sequence Orthology
more info
PubMed 
rough endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
terminal bouton IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
BDNF/NT-3 growth factors receptor
Names
neurotrophic tyrosine receptor kinase type 2
trkB tyrosine kinase
NP_001020245.1
NP_001269890.1
NP_032771.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001025074.2NP_001020245.1  BDNF/NT-3 growth factors receptor isoform a precursor

    See identical proteins and their annotated locations for NP_001020245.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Both variants 1 and 3 encode the same isoform.
    Source sequence(s)
    AC154755, AK147391, CJ098737
    Consensus CDS
    CCDS26573.1
    UniProtKB/Swiss-Prot
    P15209
    Related
    ENSMUSP00000078757, ENSMUST00000079828
    Conserved Domains (8) summary
    cd05855
    Location:301379
    Ig_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB
    smart00082
    Location:148193
    LRRCT; Leucine rich repeat C-terminal domain
    smart00410
    Location:204283
    IG_like; Immunoglobulin like
    pfam07714
    Location:537806
    Pkinase_Tyr; Protein tyrosine kinase
    pfam13855
    Location:92150
    LRR_8; Leucine rich repeat
    cd05093
    Location:531818
    PTKc_TrkB; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase B
    sd00031
    Location:96116
    LRR_1; leucine-rich repeat [structural motif]
    cl11960
    Location:204283
    Ig; Immunoglobulin domain
  2. NM_001282961.1NP_001269890.1  BDNF/NT-3 growth factors receptor isoform a precursor

    See identical proteins and their annotated locations for NP_001269890.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Both variants 1 and 3 encode the same isoform (a).
    Source sequence(s)
    AC154755, AK147391, AK160789
    Consensus CDS
    CCDS26573.1
    UniProtKB/Swiss-Prot
    P15209
    Conserved Domains (8) summary
    cd05855
    Location:301379
    Ig_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB
    smart00082
    Location:148193
    LRRCT; Leucine rich repeat C-terminal domain
    smart00410
    Location:204283
    IG_like; Immunoglobulin like
    pfam07714
    Location:537806
    Pkinase_Tyr; Protein tyrosine kinase
    pfam13855
    Location:92150
    LRR_8; Leucine rich repeat
    cd05093
    Location:531818
    PTKc_TrkB; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase B
    sd00031
    Location:96116
    LRR_1; leucine-rich repeat [structural motif]
    cl11960
    Location:204283
    Ig; Immunoglobulin domain
  3. NM_008745.3NP_032771.1  BDNF/NT-3 growth factors receptor isoform b precursor

    See identical proteins and their annotated locations for NP_032771.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks several exons and uses an alternate 3'-terminal exon, compared to variant 1. The encoded isoform (b) has a shorter and distinct C-terminus, compared to isoform a.
    Source sequence(s)
    AK018789, AK147441, AK160789, BP757570
    Consensus CDS
    CCDS36685.1
    UniProtKB/Swiss-Prot
    P15209
    UniProtKB/TrEMBL
    Q3UHE3
    Related
    ENSMUSP00000105464, ENSMUST00000109838
    Conserved Domains (6) summary
    cd05855
    Location:301379
    Ig_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB
    smart00082
    Location:148193
    LRRCT; Leucine rich repeat C-terminal domain
    smart00410
    Location:204283
    IG_like; Immunoglobulin like
    pfam13855
    Location:92150
    LRR_8; Leucine rich repeat
    sd00031
    Location:96116
    LRR_1; leucine-rich repeat [structural motif]
    cl11960
    Location:204283
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000079.6 Reference GRCm38.p3 C57BL/6J

    Range
    58806569..59133970
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006517149.2XP_006517212.1  

    See identical proteins and their annotated locations for XP_006517212.1

    UniProtKB/Swiss-Prot
    P15209
    Conserved Domains (8) summary
    cd05855
    Location:301379
    Ig_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB
    smart00082
    Location:148193
    LRRCT; Leucine rich repeat C-terminal domain
    smart00410
    Location:204283
    IG_like; Immunoglobulin like
    pfam07714
    Location:537806
    Pkinase_Tyr; Protein tyrosine kinase
    pfam13855
    Location:92150
    LRR_8; Leucine rich repeat
    cd05093
    Location:531818
    PTKc_TrkB; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase B
    sd00031
    Location:96116
    LRR_1; leucine-rich repeat [structural motif]
    cl11960
    Location:204283
    Ig; Immunoglobulin domain
  2. XM_006517150.2XP_006517213.1  

    Conserved Domains (6) summary
    cd05855
    Location:301379
    Ig_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB
    smart00082
    Location:148193
    LRRCT; Leucine rich repeat C-terminal domain
    smart00410
    Location:204283
    IG_like; Immunoglobulin like
    pfam13855
    Location:92150
    LRR_8; Leucine rich repeat
    sd00031
    Location:96116
    LRR_1; leucine-rich repeat [structural motif]
    cl11960
    Location:204283
    Ig; Immunoglobulin domain
  3. XM_006517151.2XP_006517214.1  

    Conserved Domains (6) summary
    cd05855
    Location:301379
    Ig_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB
    smart00082
    Location:148193
    LRRCT; Leucine rich repeat C-terminal domain
    smart00410
    Location:204283
    IG_like; Immunoglobulin like
    pfam13855
    Location:92150
    LRR_8; Leucine rich repeat
    sd00031
    Location:96116
    LRR_1; leucine-rich repeat [structural motif]
    cl11960
    Location:204283
    Ig; Immunoglobulin domain
  4. XM_006517152.2XP_006517215.1  

    See identical proteins and their annotated locations for XP_006517215.1

    UniProtKB/Swiss-Prot
    P15209
    UniProtKB/TrEMBL
    Q3UHE3
    Conserved Domains (6) summary
    cd05855
    Location:301379
    Ig_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB
    smart00082
    Location:148193
    LRRCT; Leucine rich repeat C-terminal domain
    smart00410
    Location:204283
    IG_like; Immunoglobulin like
    pfam13855
    Location:92150
    LRR_8; Leucine rich repeat
    sd00031
    Location:96116
    LRR_1; leucine-rich repeat [structural motif]
    cl11960
    Location:204283
    Ig; Immunoglobulin domain

Alternate Mm_Celera

Genomic

  1. AC_000035.1 Alternate Mm_Celera

    Range
    59869802..60188461
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)