cyn-13 Peptidyl-prolyl cis-trans isomerase;Peptidyl-prolyl cis-trans isomerase E [Caenorhabditis elegans] - Gene

Summary

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Gene symbol: cyn-13
Gene description: Peptidyl-prolyl cis-trans isomerase;Peptidyl-prolyl cis-trans isomerase E
Primary source: WormBase:WBGene00000889
Locus tag: CELE_Y116A8C.34
See related: AllianceGenome:WB:WBGene00000889
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables nuclease activity. Involved in apoptotic DNA fragmentation. Predicted to be active in cytoplasm. Orthologous to human PPIE (peptidylprolyl isomerase E). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See cyn-13 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 3

Sequence:: Chromosome: IV; NC_003282.8 (17111081..17116657, complement)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Y116A8C.33 (e-PCR)
- UniSTS:321850

Y116A8C.34 (e-PCR)
- UniSTS:321851

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables cyclosporin A binding	IBA Inferred from Biological aspect of Ancestor more info
enables isomerase activity	IEA Inferred from Electronic Annotation more info
enables nuclease activity	IDA Inferred from Direct Assay more info	PubMed
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables peptidyl-prolyl cis-trans isomerase activity	IBA Inferred from Biological aspect of Ancestor more info
enables peptidyl-prolyl cis-trans isomerase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in apoptotic DNA fragmentation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in apoptotic DNA fragmentation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in apoptotic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in protein folding	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein folding	IEA Inferred from Electronic Annotation more info
involved_in protein peptidyl-prolyl isomerization	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein peptidyl-prolyl isomerization	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of catalytic step 2 spliceosome	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in intracellular membrane-bounded organelle	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Peptidyl-prolyl cis-trans isomerase;Peptidyl-prolyl cis-trans isomerase E

NP_001255925.1

Confirmed by transcript evidence

NP_001255926.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

17111081..17116657 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001268996.2 → NP_001255925.1 Peptidyl-prolyl cis-trans isomerase E [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001255925.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9U2S6

Conserved Domains (3) summary

COG0724
Location:10 → 115

RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]

cd01926
Location:139 → 297

cyclophilin_ABH_like; cyclophilin_ABH_like: Cyclophilin A, B and H-like cyclophilin-type peptidylprolyl cis- trans isomerase (PPIase) domain. This family represents the archetypal cystolic cyclophilin similar to human cyclophilins A, B and H. PPIase is an enzyme which ...

cd12347
Location:13 → 85

RRM_PPIE; RNA recognition motif in cyclophilin-33 (Cyp33) and similar proteins
NM_001268997.3 → NP_001255926.1 Peptidyl-prolyl cis-trans isomerase [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001255926.1

Status: REVIEWED

UniProtKB/TrEMBL

D3NQB1

Conserved Domains (1) summary

cl00197
Location:2 → 69

cyclophilin; cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the ...