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Asb13 ankyrin repeat and SOCS box-containing 13 [ Mus musculus (house mouse) ]

Gene ID: 142688, updated on 5-Mar-2024

Summary

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Official Symbol
Asb13provided by MGI
Official Full Name
ankyrin repeat and SOCS box-containing 13provided by MGI
Primary source
MGI:MGI:2145525
See related
Ensembl:ENSMUSG00000033781 AllianceGenome:MGI:2145525
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Asb-13; 2210015B19Rik; 6430573K02Rik
Summary
Predicted to be involved in intracellular signal transduction. Orthologous to human ASB13 (ankyrin repeat and SOCS box containing 13). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in kidney adult (RPKM 25.8), liver adult (RPKM 18.0) and 27 other tissues See more
Orthologs
human all
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Genomic context

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Location:
13 A1; 13 2.03 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (3683589..3703822)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (3633589..3653822)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene GDP dissociation inhibitor 2 Neighboring gene transcription activation suppressor family member 2 Neighboring gene STARR-positive B cell enhancer ABC_E9151 Neighboring gene STARR-seq mESC enhancer starr_33488 Neighboring gene STARR-seq mESC enhancer starr_33489 Neighboring gene general transcription factor II A, 2 pseudogene Neighboring gene predicted gene, 35190 Neighboring gene VISTA enhancer mm41 Neighboring gene STARR-seq mESC enhancer starr_33491 Neighboring gene STARR-seq mESC enhancer starr_33492 Neighboring gene STARR-seq mESC enhancer starr_33493 Neighboring gene predicted gene, 53803

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The SOCS box: a tale of destruction and degradation. Kile BT, et al. Trends Biochem Sci, 2002 May. PMID 12076535
  2. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
  3. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249
  4. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
  5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
ankyrin repeat and SOCS box protein 13
Names
ankyrin repeat and SOCS box-containing protein 13
ankyrin repeat domain-containing SOCS box protein 13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001267724.1 → NP_001254653.1  ankyrin repeat and SOCS box protein 13 isoform 3

    See identical proteins and their annotated locations for NP_001254653.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) has multiple differences in the coding region but maintains the reading frame, compared to variant 1. This variant encodes isoform 3, which is shorter than isoform 1.
    Source sequence(s)
    AC129597, BG080214
    Conserved Domains (3) summary
    cd00204
    Location:15 → 79
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam13857
    Location:22 → 76
    Ank_5; Ankyrin repeats (many copies)
    sd00045
    Location:36 → 66
    ANK; ANK repeat [structural motif]

  2. NM_178283.4 → NP_840068.1  ankyrin repeat and SOCS box protein 13 isoform 1

    See identical proteins and their annotated locations for NP_840068.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC129597, AK078289
    Consensus CDS
    CCDS36582.1
    UniProtKB/Swiss-Prot
    Q8VBX0
    Related
    ENSMUSP00000046476.7, ENSMUST00000042288.8
    Conserved Domains (4) summary
    cd00204
    Location:46 → 170
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd03729
    Location:237 → 278
    SOCS_ASB13; SOCS (suppressors of cytokine signaling) box of ASB13-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. ...
    sd00045
    Location:119 → 147
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:152 → 202
    Ank_4; Ankyrin repeats (many copies)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    3683589..3703822
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_003950427.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8VBX0.1 GenPept UniProtKB/Swiss-Prot:Q8VBX0

Gene LinkOut

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