DOCK11 dedicator of cytokinesis 11 [Homo sapiens] - Gene

Help top of page

Summary

Official Symbol: DOCK11provided by HGNC
Official Full Name: dedicator of cytokinesis 11provided by HGNC
Primary source: HGNC:23483
Locus tag: RP13-128O4.1
See related: Ensembl:ENSG00000147251; HPRD:06492; MIM:300681; Vega:OTTHUMG00000022256
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: ACG; ZIZ2; bB128O4.1; FLJ32122; FLJ43653

Help top of page

Genomic context

Location :: Xq24

Sequence :: Chromosome: X; NC_000023.10 (117629872..117820123)

See DOCK11 in Epigenomics, MapViewer

Chromosome X - NC_000023.10 Genomic Context describing neighboring genes

Help top of page

Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

Help top of page

Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Submit: New GeneRIF Correction

Help top of page

Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

Help top of page

Products	Interactant	Other Gene	Complex	Source	Pubs	Description
BioGRID:126589	BioGRID:107252	CALM1		BioGRID	PubMed	Reconstituted Complex
BioGRID:126589	BioGRID:113164	UBC		BioGRID	PubMed	Affinity Capture-MS

Function	Evidence Code	Pubs
GTP binding	IEA Inferred from Electronic Annotation more info
GTPase binding	IEA Inferred from Electronic Annotation more info
Rho GTPase binding	IEA Inferred from Electronic Annotation more info
Rho guanyl-nucleotide exchange factor activity	IEA Inferred from Electronic Annotation more info
guanyl-nucleotide exchange factor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
blood coagulation	TAS Traceable Author Statement more info
regulation of catalytic activity	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
cytosol	TAS Traceable Author Statement more info

General protein information

Preferred Names: dedicator of cytokinesis protein 11

Names: dedicator of cytokinesis protein 11; zizimin2; zizimin-2; bB128O4.1.1 (novel protein); Activated Cdc42-associated guanine nucleotide exchange factor, ACG

Help top of page

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_144658.3 → NP_653259.3 dedicator of cytokinesis protein 11

Status: VALIDATED

Source sequence(s)

AK056684, AK124735, AY692226

Consensus CDS

CCDS35373.1

UniProtKB/Swiss-Prot

Q5JSL3

Related

ENSP00000276202, OTTHUMP00000215703, ENST00000276202, OTTHUMT00000356002

Conserved Domains (4) summary

pfam11878
Location:51 – 144
Blast Score: 350

DUF3398; Domain of unknown function (DUF3398)

cd08697
Location:639 – 828
Blast Score: 851

C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins

cd00821
Location:168 – 269
Blast Score: 152

PH; Pleckstrin homology (PH) domain

pfam06920
Location:1852 – 2029
Blast Score: 658

Ded_cyto; Dedicator of cytokinesis

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000023.10 Reference GRCh37.p5 Primary Assembly

Range

117629872..117820123

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000155.1 Alternate HuRef

Range

107125453..107314333

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Help top of page

Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AC007021.3	None
genomic	AL391237.12	CAI41407.1
genomic	AL391280.15	CAI41411.1
genomic	CH471161.2	EAW89895.1
mRNA	AA490413.1	None
mRNA	AI361832.1	None
mRNA	AI936555.1	None
mRNA	AK054649.1	BAG51406.1
mRNA	AK056684.1	BAB71253.1
mRNA	AK124735.1	None
mRNA	AK125641.1	BAC86230.1
mRNA	AW968823.1	None
mRNA	AY692226.1	AAU04438.1
mRNA	BC035593.1	None
mRNA	BC042053.1	None
mRNA	BC047713.1	AAH47713.1
mRNA	BF513250.1	None
other-genetic	BC156530.1	AAI56531.1