Cdk2 cyclin-dependent kinase 2 [Mus musculus (house mouse)] - Gene

Summary

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Official Symbol: Cdk2provided by MGI
Official Full Name: cyclin-dependent kinase 2provided by MGI
Primary source: MGI:104772
See related: Ensembl:ENSMUSG00000025358
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: A630093N05Rik

Genomic context

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Location :: 10 D3; 10

Sequence :: Chromosome: 10; NC_000076.6 (128697939..128705051, complement)

See Cdk2 in Epigenomics

Chromosome 10 - NC_000076.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence

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Bibliography

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GeneRIFs: Gene References Into Functions What's a GeneRIF?

CDK2 controls the balance between immunity and tolerance by regulating both conventional T cell (Tconv) and regulatory T (Treg) cell function; Cdk2 is not required for CD4+ T cell cycle progression.
Title: Cyclin-dependent kinase 2 controls peripheral immune tolerance.
exquisite sensitivity of the cell-of-origin to E2f and Cdk activity can be exploited to prevent Rb pathway-induced cancer in vivo without perturbing normal cell division
Title: Established and new mouse models reveal E2f1 and Cdk2 dependency of retinoblastoma, and expose effective strategies to block tumor initiation.
resulting unrestricted cyclin A/CDK2 activity is accompanied by shortening of the cell cycle, increased replication fork velocity, and DNA damage
Title: The CDK subunit CKS2 counteracts CKS1 to control cyclin A/CDK2 activity in maintaining replicative fidelity and neurodevelopment.
Data demonstrate the induction of neurogenic divisions in the absence of critical mediators of G1/S transition-Cdk2 and Cdk4, and highlight their evolutionary importance in the determination of cortical thickness.
Title: Loss of Cdk2 and Cdk4 induces a switch from proliferation to differentiation in neural stem cells.
Lack of CDK1, but not of Cdk2, does not leads to female infertility due to a failure of the resumption of meiosis in the oocyte.
Title: Cdk1, but not Cdk2, is the sole Cdk that is essential and sufficient to drive resumption of meiosis in mouse oocytes.
inhibitory phosphorylation of CDK2 had a major role in controlling cyclin E-associated kinase activity and thus both determined the timing of DNA replication in a normal cell cycle and regulated centrosome duplication
Title: Loss of cyclin-dependent kinase 2 (CDK2) inhibitory phosphorylation in a CDK2AF knock-in mouse causes misregulation of DNA replication and centrosome duplication.
observed that 87% of Cdk2-null mice were protected from ErbB-2-induced mammary tumorigenesis
Title: Cdk2-null mice are resistant to ErbB-2-induced mammary tumorigenesis.
Medium conditioned by macrophages interferes with the upregulation of cyclin A levels and cdk2 activity.
Title: Macrophage-conditioned medium inhibits the activation of cyclin-dependent kinase 2 by adipogenic inducers in 3T3-L1 preadipocytes.
Data show that protein expression of cyclins D1 and B1 and cyclin-dependent kinases 2 and 4 was downregulated upon LXR activation.
Title: Liver X receptors inhibit macrophage proliferation through downregulation of cyclins D1 and B1 and cyclin-dependent kinases 2 and 4.
During CNS development, Cdk2 loss did not affect oligodendrocyte cell numbers or myelination. After CNS demyelination, CDK2 loss clearly altered adult oligodendrocyte stem cell renewal, cell cycle exit, and differentiation.
Title: Cdk2 loss accelerates precursor differentiation and remyelination in the adult central nervous system.

Submit: New GeneRIF Correction See all (62)

Alleles

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Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (Floxed/Frt) (1) 1 citation
Targeted (knock-out) (2) 1 citation
Gene trapped (1)
Targeted (knock-in) (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Source	Pubs	Description
NP_058036.1	NP_033958.1	Ccna2	BIND	PubMed	Ccna2 (cyclin A) interacts with Cdk2 (p33).
NP_058036.1	NP_031657.1	Ccnd1	BIND	PubMed	CDK2 isoform 2 interacts with Cyclin D1.
NP_058036.1	NP_031695.1	Cdkn1a	BIND	PubMed	CDK2 isoform 2 interacts with p21Cip1.
NP_058036.1	NP_034005.2	Cdkn1b	BIND	PubMed	Cdkn1b (p27) interacts with Cdk2 (p33).
NP_058036.1	NP_034005.2	Cdkn1b	BIND	PubMed	CDK2 isoform 2 interacts with p27Kip1.
NP_058036.1	NP_033055.1	Rb1	BIND	PubMed	CDK2 isoform 2 bound to D-type cyclin phosphorylates pRb.
NP_904326.1	NP_033958.1	Ccna2	BIND	PubMed	Ccna2 (cyclin A) interacts with Cdk2 (p38).
NP_904326.1	NP_031657.1	Ccnd1	BIND	PubMed	CDK2 isoform 1 interacts with Cyclin D1
NP_904326.1	NP_031695.1	Cdkn1a	BIND	PubMed	CDK2 isoform 1 interacts with p21Cip1.
NP_904326.1	NP_034005.2	Cdkn1b	BIND	PubMed	Cdkn1b (p27) interacts with Cdk2 (p38).
NP_904326.1	NP_034005.2	Cdkn1b	BIND	PubMed	CDK2 isoform 1 interacts with p27Kip1.
NP_904326.1	NP_033055.1	Rb1	BIND	PubMed	CDK2 isoform 1 bound to D-type cyclin phosphorylates pRb.
BioGRID:198644	BioGRID:198318	Bcl2	BioGRID	PubMed	Biochemical Activity
BioGRID:198644	BioGRID:107338	CCNE1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:198644	BioGRID:198544	Ccna1	BioGRID	PubMed	Affinity Capture-Western
	NP_033958.1	Ccna2	BIND	PubMed	Ccna2 (cyclin A) interacts with Cdk2.
	NP_033958.1	Ccna2	BIND	PubMed	Cdk2 interacts with Ccna2 (Cyclin A2).
BioGRID:198644	BioGRID:198545	Ccna2	BioGRID	PubMed	Affinity Capture-Western
	NP_758505.2	Ccnb1	BIND	PubMed	Ccnb1 (cyclin B1) interacts with Cdk2.
BioGRID:198644	BioGRID:198549	Ccnd2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:198644	BioGRID:198552	Ccne1	BioGRID	PubMed	Affinity Capture-Western; Co-fractionation
BioGRID:198644	BioGRID:204750	Cdc6	BioGRID	PubMed	Affinity Capture-Western
	NP_031695.1	Cdkn1a	BIND	PubMed	Cdk2 interacts with p21. This interaction was modelled on a demonstrated interaction between cdk2 and p21 both from golden hamster.
BioGRID:198644	BioGRID:198651	Cdkn1a	BioGRID	PubMed	Affinity Capture-Western; Co-localization
	NP_034005.2	Cdkn1b	BIND	PubMed	Cdkn1b (p27) interacts with Cdk2.
	NP_034005.2	Cdkn1b	BIND	PubMed	An unspecified isoform of Cdk2 interacts, albeit weakly, with Cdkn1b (p27). This interaction was modeled on a demonstrated interaction between Cdk2 from an unspecified species and mouse Cdkn1b (p27).
	NP_034005.2	Cdkn1b	BIND	PubMed	Cdkn1b (p27) interacts with Cdk2. This interaction was modeled on a demonstrated interaction between Cdkn1b from an unspecified species and Xenopus Cdk2.
BioGRID:198644	BioGRID:198652	Cdkn1b	BioGRID	PubMed	Affinity Capture-Western; Biochemical Activity
BioGRID:198644	BioGRID:198667	Cebpa	BioGRID	PubMed	Affinity Capture-Western
BioGRID:198644	BioGRID:224997	H1	BioGRID	PubMed	Biochemical Activity
BioGRID:198644	BioGRID:109260	H1F0	BioGRID	PubMed	Biochemical Activity
BioGRID:198644	BioGRID:200145	H1f0	BioGRID	PubMed	Biochemical Activity
BioGRID:198644	BioGRID:109275	HIST1H1A	BioGRID	PubMed	Biochemical Activity
BioGRID:198644	BioGRID:109264	HIST1H1B	BioGRID	PubMed	Biochemical Activity
BioGRID:198644	BioGRID:170598	HIST1H1C	BioGRID	PubMed	Biochemical Activity
BioGRID:198644	BioGRID:219818	Hist1h1a	BioGRID	PubMed	Biochemical Activity
BioGRID:198644	BioGRID:206061	Hist1h1c	BioGRID	PubMed	Biochemical Activity
BioGRID:198644	BioGRID:201218	Ltb	BioGRID	PubMed	Biochemical Activity
BioGRID:198644	BioGRID:201823	Npm1	BioGRID	PubMed	Biochemical Activity
BioGRID:198644	BioGRID:202049	Pcna	BioGRID	PubMed	Affinity Capture-Western
BioGRID:198644	BioGRID:202337	Ppp1cc	BioGRID	PubMed	Affinity Capture-Western
BioGRID:198644	BioGRID:202515	Pura	BioGRID	PubMed	Co-localization
	NP_033055.1	Rb1	BIND	PubMed	CDK2 interacts and phosphorylates Rb. This interaction was modelled on a demonstrated interaction between mouse CDK2 and Rb from unspecified species.
BioGRID:198644	BioGRID:202815	Rb1	BioGRID	PubMed	Biochemical Activity
BioGRID:198644	BioGRID:203344	Smn1	BioGRID	PubMed	Co-localization
BioGRID:198644	BioGRID:204323	Trp53	BioGRID	PubMed	Biochemical Activity
	NP_033542.2	Wee1	BIND	PubMed	Wee1 interacts with and phosphorylates Cdk2. This interaction was modelled on a demonstrated interaction between mouse Wee1 and human Cdk2.

Pathways from BioSystems

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APC/C-mediated degradation of cell cycle proteins, organism-specific biosystem (from REACTOME)
APC/C-mediated degradation of cell cycle proteins, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Activation of ATR in response to replication stress, organism-specific biosystem (from REACTOME)
Activation of ATR in response to replication stress, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Activation of the pre-replicative complex, organism-specific biosystem (from REACTOME)
Activation of the pre-replicative complex, organism-specific biosystemcomputationally inferred pathway (not manually curated)
B Cell Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
B Cell Receptor Signaling Pathway, organism-specific biosystemThe B cell receptor includes membrane ???? heavy chain molecules bound to a light chain and an Ig alpha (CD79A)/Ig beta (CD79B) heterodimer. Activation of the B cell receptor involves phosphorylation...
CDK-mediated phosphorylation and removal of Cdc6, organism-specific biosystem (from REACTOME)
CDK-mediated phosphorylation and removal of Cdc6, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Cell Cycle, organism-specific biosystem (from REACTOME)
Cell Cycle, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Cell Cycle Checkpoints, organism-specific biosystem (from REACTOME)
Cell Cycle Checkpoints, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Cell Cycle, Mitotic, organism-specific biosystem (from REACTOME)
Cell Cycle, Mitotic, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Cell cycle, organism-specific biosystem (from KEGG)
Cell cycle, organism-specific biosystemMitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cycli...
Cell cycle, organism-specific biosystem (from WikiPathways)
Cell cycle, organism-specific biosystem(From http://en.wikipedia.org/wiki/Cell_cycle) The cell cycle is the series of events that takes place in a cell leading to its division and duplication (replication). Regulation of the cell cycle in...
Cell cycle, conserved biosystem (from KEGG)
Cell cycle, conserved biosystemMitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cycli...
Cell cycle signaling pathway, organism-specific biosystem (from LIPID MAPS)
Cell cycle signaling pathway, organism-specific biosystem
Cell cycle signaling pathway
Cyclin A:Cdk2-associated events at S phase entry, organism-specific biosystem (from REACTOME)
Cyclin A:Cdk2-associated events at S phase entry, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Cyclin E associated events during G1/S transition, organism-specific biosystem (from REACTOME)
Cyclin E associated events during G1/S transition, organism-specific biosystemcomputationally inferred pathway (not manually curated)
DNA Replication, organism-specific biosystem (from WikiPathways)
DNA Replication, organism-specific biosystemDNA replication, the basis for biological inheritance, is a fundamental process occurring in all living organisms to copy their DNA. This process is "replication" in that each strand of the original ...
DNA Replication, organism-specific biosystem (from REACTOME)
DNA Replication, organism-specific biosystemcomputationally inferred pathway (not manually curated)
DNA Replication Pre-Initiation, organism-specific biosystem (from REACTOME)
DNA Replication Pre-Initiation, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Delta-Notch Signaling Pathway, organism-specific biosystem (from WikiPathways)
Delta-Notch Signaling Pathway, organism-specific biosystemThere are 4 Notch receptors in humans (Notch 1-4) that bind to a family of 5 ligands (Jagged 1 and 2 and Delta-like 1-3). The Notch receptors are expressed on the cell surface as heterodimeric protei...
Epstein-Barr virus infection, organism-specific biosystem (from KEGG)
Epstein-Barr virus infection, organism-specific biosystemEpstein-Barr virus (EBV) is a ubiquitous human herpesvirus that is associated with oncogenesis. EBV infection to primary human B lymphocytes leads to induction of EBV-specific HLA-restricted cytotoxi...
Epstein-Barr virus infection, conserved biosystem (from KEGG)
Epstein-Barr virus infection, conserved biosystemEpstein-Barr virus (EBV) is a ubiquitous human herpesvirus that is associated with oncogenesis. EBV infection to primary human B lymphocytes leads to induction of EBV-specific HLA-restricted cytotoxi...
Factors involved in megakaryocyte development and platelet production, organism-specific biosystem (from REACTOME)
Factors involved in megakaryocyte development and platelet production, organism-specific biosystemcomputationally inferred pathway (not manually curated)
G0 and Early G1, organism-specific biosystem (from REACTOME)
G0 and Early G1, organism-specific biosystemcomputationally inferred pathway (not manually curated)
G1 to S cell cycle control, organism-specific biosystem (from WikiPathways)
G1 to S cell cycle control, organism-specific biosystemIn the G1 phase there are two types of DNA damage responses, the p53-dependent and the p53-independent pathways. The p53-dependent responses inhibit CDKs through the up-regulation of genes encoding C...
G1/S DNA Damage Checkpoints, organism-specific biosystem (from REACTOME)
G1/S DNA Damage Checkpoints, organism-specific biosystemcomputationally inferred pathway (not manually curated)
G1/S Transition, organism-specific biosystem (from REACTOME)
G1/S Transition, organism-specific biosystemcomputationally inferred pathway (not manually curated)
G2 Phase, organism-specific biosystem (from REACTOME)
G2 Phase, organism-specific biosystemcomputationally inferred pathway (not manually curated)
G2/M Checkpoints, organism-specific biosystem (from REACTOME)
G2/M Checkpoints, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Hemostasis, organism-specific biosystem (from REACTOME)
Hemostasis, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Hepatitis B, organism-specific biosystem (from KEGG)
Hepatitis B, organism-specific biosystemHepatitis B virus (HBV) is an enveloped virus and contains a partially double-stranded relaxed circular DNA (RC-DNA) genome. After entry into hepatocytes, HBV RC-DNA is transported to the nucleus and...
Herpes simplex infection, organism-specific biosystem (from KEGG)
Herpes simplex infection, organism-specific biosystemHerpes simplex virus (HSV) infections are very common worldwide, with the prevalence of HSV-1 reaching up to 80%-90%. Primary infection with HSV takes place in the mucosa, followed by the establishme...
Herpes simplex infection, conserved biosystem (from KEGG)
Herpes simplex infection, conserved biosystemHerpes simplex virus (HSV) infections are very common worldwide, with the prevalence of HSV-1 reaching up to 80%-90%. Primary infection with HSV takes place in the mucosa, followed by the establishme...
IL-7 Signaling Pathway, organism-specific biosystem (from WikiPathways)
IL-7 Signaling Pathway, organism-specific biosystem
IL-7 Signaling Pathway
Id Signaling Pathway, organism-specific biosystem (from WikiPathways)
Id Signaling Pathway, organism-specific biosystemInhibitor of DNA binding (ID) proteins are members of the helix-loop-helix (HLH) family of proteins which lack a DNA binding domain themselves but bind to other family members inhibiting their DNA bi...
M/G1 Transition, organism-specific biosystem (from REACTOME)
M/G1 Transition, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Measles, organism-specific biosystem (from KEGG)
Measles, organism-specific biosystemMeasles virus (MV) is highly contagious virus that leads infant death worldwide. Humans are the unique natural reservoir for this virus. It causes severe immunosuppression favouring secondary bacteri...
Measles, conserved biosystem (from KEGG)
Measles, conserved biosystemMeasles virus (MV) is highly contagious virus that leads infant death worldwide. Humans are the unique natural reservoir for this virus. It causes severe immunosuppression favouring secondary bacteri...
Meiosis, organism-specific biosystem (from REACTOME)
Meiosis, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Meiotic Recombination, organism-specific biosystem (from REACTOME)
Meiotic Recombination, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Mitotic G1-G1/S phases, organism-specific biosystem (from REACTOME)
Mitotic G1-G1/S phases, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Mitotic G2-G2/M phases, organism-specific biosystem (from REACTOME)
Mitotic G2-G2/M phases, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Oocyte meiosis, organism-specific biosystem (from KEGG)
Oocyte meiosis, organism-specific biosystemDuring meiosis, a single round of DNA replication is followed by two rounds of chromosome segregation, called meiosis I and meiosis II. At meiosis I, homologous chromosomes recombine and then segrega...
Oocyte meiosis, conserved biosystem (from KEGG)
Oocyte meiosis, conserved biosystemDuring meiosis, a single round of DNA replication is followed by two rounds of chromosome segregation, called meiosis I and meiosis II. At meiosis I, homologous chromosomes recombine and then segrega...
Orc1 removal from chromatin, organism-specific biosystem (from REACTOME)
Orc1 removal from chromatin, organism-specific biosystemcomputationally inferred pathway (not manually curated)
PI3K-Akt signaling pathway, organism-specific biosystem (from KEGG)
PI3K-Akt signaling pathway, organism-specific biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
PI3K-Akt signaling pathway, conserved biosystem (from KEGG)
PI3K-Akt signaling pathway, conserved biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
Pathways in cancer, organism-specific biosystem (from KEGG)
Pathways in cancer, organism-specific biosystem
Pathways in cancer
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes, organism-specific biosystem (from REACTOME)
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes, organism-specific biosystemcomputationally inferred pathway (not manually curated)
PluriNetWork, organism-specific biosystem (from WikiPathways)
PluriNetWork, organism-specific biosystemThe aim of the PluriNetWork is to give an overview of specific mechanisms associated with pluripotency in mouse. Each node represents a gene and its corresponding protein product. As stated, we inten...
Progesterone-mediated oocyte maturation, organism-specific biosystem (from KEGG)
Progesterone-mediated oocyte maturation, organism-specific biosystemXenopus oocytes are naturally arrested at G2 of meiosis I. Exposure to either insulin/IGF-1 or the steroid hormone progesterone breaks this arrest and induces resumption of the two meiotic division c...
Progesterone-mediated oocyte maturation, conserved biosystem (from KEGG)
Progesterone-mediated oocyte maturation, conserved biosystemXenopus oocytes are naturally arrested at G2 of meiosis I. Exposure to either insulin/IGF-1 or the steroid hormone progesterone breaks this arrest and induces resumption of the two meiotic division c...
Prostate cancer, organism-specific biosystem (from KEGG)
Prostate cancer, organism-specific biosystemProstate cancer constitutes a major health problem in Western countries. It is the most frequently diagnosed cancer among men and the second leading cause of male cancer deaths. The identification of...
Prostate cancer, conserved biosystem (from KEGG)
Prostate cancer, conserved biosystemProstate cancer constitutes a major health problem in Western countries. It is the most frequently diagnosed cancer among men and the second leading cause of male cancer deaths. The identification of...
Regulation of APC/C activators between G1/S and early anaphase, organism-specific biosystem (from REACTOME)
Regulation of APC/C activators between G1/S and early anaphase, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Regulation of DNA replication, organism-specific biosystem (from REACTOME)
Regulation of DNA replication, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Regulation of mitotic cell cycle, organism-specific biosystem (from REACTOME)
Regulation of mitotic cell cycle, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Removal of licensing factors from origins, organism-specific biosystem (from REACTOME)
Removal of licensing factors from origins, organism-specific biosystemcomputationally inferred pathway (not manually curated)
S Phase, organism-specific biosystem (from REACTOME)
S Phase, organism-specific biosystemcomputationally inferred pathway (not manually curated)
SCF(Skp2)-mediated degradation of p27/p21, organism-specific biosystem (from REACTOME)
SCF(Skp2)-mediated degradation of p27/p21, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Small cell lung cancer, organism-specific biosystem (from KEGG)
Small cell lung cancer, organism-specific biosystemLung cancer is a leading cause of cancer death among men and women in industrialized countries. Small cell lung carcinoma (SCLC) is a highly aggressive neoplasm, which accounts for approximately 25% ...
Small cell lung cancer, conserved biosystem (from KEGG)
Small cell lung cancer, conserved biosystemLung cancer is a leading cause of cancer death among men and women in industrialized countries. Small cell lung carcinoma (SCLC) is a highly aggressive neoplasm, which accounts for approximately 25% ...
Spinal Cord Injury, organism-specific biosystem (from WikiPathways)
Spinal Cord Injury, organism-specific biosystemThis pathway provides an overview of cell types, therapeutic targets, drugs, new proposed targets and pathways implicated in spinal cord injury. Spinal cord injury is a complex multistep process that...
Switching of origins to a post-replicative state, organism-specific biosystem (from REACTOME)
Switching of origins to a post-replicative state, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Synthesis of DNA, organism-specific biosystem (from REACTOME)
Synthesis of DNA, organism-specific biosystemcomputationally inferred pathway (not manually curated)
TGF-beta Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
TGF-beta Receptor Signaling Pathway, organism-specific biosystem
TGF-beta Receptor Signaling Pathway
Viral carcinogenesis, organism-specific biosystem (from KEGG)
Viral carcinogenesis, organism-specific biosystemThere is a strong association between viruses and the development of human malignancies. We now know that at least six human viruses, Epstein-Barr virus (EBV), hepatitis B virus (HBV), hepatitis C vi...
Viral carcinogenesis, conserved biosystem (from KEGG)
Viral carcinogenesis, conserved biosystemThere is a strong association between viruses and the development of human malignancies. We now know that at least six human viruses, Epstein-Barr virus (EBV), hepatitis B virus (HBV), hepatitis C vi...
miRNA regulation of DNA Damage Response, organism-specific biosystem (from WikiPathways)
miRNA regulation of DNA Damage Response, organism-specific biosystemThis is the first out of two pathways which deals with the DNA damage response. It is comprised of two central gene products (ATM and ATR) influenced by different sources of DNA damage (in blue). The...
p53 signaling pathway, organism-specific biosystem (from KEGG)
p53 signaling pathway, organism-specific biosystemp53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated ge...
p53 signaling pathway, conserved biosystem (from KEGG)
p53 signaling pathway, conserved biosystemp53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated ge...
p53-Dependent G1 DNA Damage Response, organism-specific biosystem (from REACTOME)
p53-Dependent G1 DNA Damage Response, organism-specific biosystemcomputationally inferred pathway (not manually curated)
p53-Dependent G1/S DNA damage checkpoint, organism-specific biosystem (from REACTOME)
p53-Dependent G1/S DNA damage checkpoint, organism-specific biosystemcomputationally inferred pathway (not manually curated)

General gene information

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Markers

Cdk2 (e-PCR), detects polymorphism
- UniSTS:527278

NoName (e-PCR)
- UniSTS:236489

Homology

Homologs of the Cdk2 gene: The Cdk2 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, zebrafish, fruit fly, mosquito, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, A.thaliana, and rice.
Map Viewer (Human, Rat)
OrthoDB: The Hierarchical Catalog of Eukaryotic Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
ATP binding	IEA Inferred from Electronic Annotation more info
cyclin binding	IPI Inferred from Physical Interaction more info	PubMed
cyclin binding	ISO Inferred from Sequence Orthology more info
cyclin-dependent protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
cyclin-dependent protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
kinase activity	IDA Inferred from Direct Assay more info	PubMed
metal ion binding	IEA Inferred from Electronic Annotation more info
nucleotide binding	IEA Inferred from Electronic Annotation more info
protein binding	IPI Inferred from Physical Interaction more info	PubMed
protein complex binding	ISO Inferred from Sequence Orthology more info
protein kinase activity	IDA Inferred from Direct Assay more info
protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
transferase activity	IEA Inferred from Electronic Annotation more info
transferase activity, transferring phosphorus-containing groups	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
DNA repair	IEA Inferred from Electronic Annotation more info
G1/S transition of mitotic cell cycle	IDA Inferred from Direct Assay more info	PubMed
cell cycle	IEA Inferred from Electronic Annotation more info
cell division	IEA Inferred from Electronic Annotation more info
cellular response to insulin stimulus	ISO Inferred from Sequence Orthology more info
histone phosphorylation	ISO Inferred from Sequence Orthology more info
meiosis	IEA Inferred from Electronic Annotation more info
mitosis	IEA Inferred from Electronic Annotation more info
phosphorylation	IEA Inferred from Electronic Annotation more info
positive regulation of DNA-dependent DNA replication initiation	IGI Inferred from Genetic Interaction more info
positive regulation of cell proliferation	ISO Inferred from Sequence Orthology more info
positive regulation of transcription, DNA-dependent	IGI Inferred from Genetic Interaction more info	PubMed
potassium ion transport	IGI Inferred from Genetic Interaction more info	PubMed
protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
protein phosphorylation	IEA Inferred from Electronic Annotation more info
regulation of gene silencing	ISO Inferred from Sequence Orthology more info
response to DNA damage stimulus	IEA Inferred from Electronic Annotation more info
response to cAMP	ISO Inferred from Sequence Orthology more info
response to electrical stimulus	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
Cajal body	ISO Inferred from Sequence Orthology more info
X chromosome	IDA Inferred from Direct Assay more info	PubMed
Y chromosome	IDA Inferred from Direct Assay more info	PubMed
chromosome, telomeric region	IDA Inferred from Direct Assay more info	PubMed
condensed chromosome	IDA Inferred from Direct Assay more info	PubMed
cyclin-dependent protein kinase holoenzyme complex	IPI Inferred from Physical Interaction more info	PubMed
cyclin-dependent protein kinase holoenzyme complex	ISO Inferred from Sequence Orthology more info
cytoplasm	ISO Inferred from Sequence Orthology more info
cytoskeleton	IEA Inferred from Electronic Annotation more info
cytosol	ISO Inferred from Sequence Orthology more info
endosome	ISO Inferred from Sequence Orthology more info
intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
nucleus	IDA Inferred from Direct Assay more info	PubMed
nucleus	ISO Inferred from Sequence Orthology more info
transcription factor complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: cyclin-dependent kinase 2

Names: cyclin-dependent kinase 2; cell division protein kinase 2

NP_058036.1

EC 2.7.11.22

NP_904326.1

EC 2.7.11.22

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_016756.4 → NP_058036.1 cyclin-dependent kinase 2 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame coding exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.

Source sequence(s)

AK152922, CN705407

Consensus CDS

CCDS24288.1

UniProtKB/Swiss-Prot

P97377

UniProtKB/TrEMBL

Q3U6X7

Related

ENSMUSP00000026415, ENSMUST00000026415

Conserved Domains (1) summary

pfam00069
Location:4 – 286
Blast Score: 805

Pkinase; Protein kinase domain
NM_183417.3 → NP_904326.1 cyclin-dependent kinase 2 isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AK148017, AK151979, AK152922, CN705407

Consensus CDS

CCDS24289.1

UniProtKB/Swiss-Prot

P97377

UniProtKB/TrEMBL

Q3U6X7

UniProtKB/TrEMBL

Q3UGB9

Related

ENSMUSP00000026416, ENSMUST00000026416

Conserved Domains (2) summary

cd07860
Location:3 – 334
Blast Score: 1567

STKc_CDK2_3; Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase 2 and 3

PLN00009
Location:1 – 337
Blast Score: 1182

PLN00009; cyclin-dependent kinase A; Provisional

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 103

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p1 C57BL/6J

Genomic

NC_000076.6 Reference GRCm38.p1 C57BL/6J

Range

128697939..128705051, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

AC_000032.1 Alternate Mm_Celera

Range

131090071..131097183, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Nucleotide		Protein	Strain
Heading	Accession and Version	Protein	Strain
genomic	AAHY01090100.1 (2091..9203)	None
genomic	AC117232.3 (183514..190587)	None
genomic	AJ223733.1	CAA11534.1
genomic	CH466578.1	EDL24599.1	mixed
		EDL24600.1	mixed
mRNA	AJ223732.1	CAA11533.1
mRNA	AK036589.1	None	C57BL/6J
mRNA	AK042462.1	None	C57BL/6J
mRNA	AK146845.1	BAE27476.1	C57BL/6J
mRNA	AK148017.1	BAE28290.1	C57BL/6J
mRNA	AK151979.1	BAE30846.1	C57BL/6J
mRNA	AK152922.1	BAE31597.1	C57BL/6J
mRNA	AK153983.1	BAE32294.1	NOD
mRNA	AK154997.1	BAE32983.1	NOD
mRNA	AK178832.1	None
mRNA	AK179397.1	None
mRNA	AK181235.1	None
mRNA	AK183240.1	None
mRNA	AK184593.1	None
mRNA	AK186022.1	None
mRNA	AK186779.1	None
mRNA	AK187629.1	None
mRNA	AK189612.1	None
mRNA	AK200216.1	None
mRNA	AK200296.1	None
mRNA	AK208241.1	None
mRNA	AK208316.1	None
mRNA	AK209242.1	None
mRNA	AK210959.1	None
mRNA	AK214050.1	None
mRNA	AK219393.1	None
mRNA	BC005654.1	AAH05654.1	FVB/N
mRNA	BC026145.1	None
mRNA	CN705407.1	None	C57BL/6J
mRNA	U63337.1	AAB37128.1	C57BL/6