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CDK2 cyclin dependent kinase 2 [ Homo sapiens (human) ]

Gene ID: 1017, updated on 24-Nov-2020

Summary

Official Symbol
CDK2provided by HGNC
Official Full Name
cyclin dependent kinase 2provided by HGNC
Primary source
HGNC:HGNC:1771
See related
Ensembl:ENSG00000123374 MIM:116953
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CDKN2; p33(CDK2)
Summary
This gene encodes a member of a family of serine/threonine protein kinases that participate in cell cycle regulation. The encoded protein is the catalytic subunit of the cyclin-dependent protein kinase complex, which regulates progression through the cell cycle. Activity of this protein is especially critical during the G1 to S phase transition. This protein associates with and regulated by other subunits of the complex including cyclin A or E, CDK inhibitor p21Cip1 (CDKN1A), and p27Kip1 (CDKN1B). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]
Expression
Ubiquitous expression in placenta (RPKM 29.3), bone marrow (RPKM 14.9) and 24 other tissues See more
Orthologs

Genomic context

See CDK2 in Genome Data Viewer
Location:
12q13.2
Exon count:
8
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (55966830..55972789)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (56360556..56366573)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene diacylglycerol kinase alpha Neighboring gene premelanosome protein Neighboring gene RAB13, member RAS oncogene family pseudogene Neighboring gene RAB5B, member RAS oncogene family Neighboring gene sulfite oxidase

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
A novel susceptibility locus for type 1 diabetes on Chr12q13 identified by a genome-wide association study.
GeneReviews: Not available
Association analyses identify three susceptibility Loci for vitiligo in the Chinese Han population.
GeneReviews: Not available
Genetics of rheumatoid arthritis contributes to biology and drug discovery.
GeneReviews: Not available
Genome-wide association study identifies three new susceptibility loci for adult asthma in the Japanese population.
GeneReviews: Not available

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat CDK2 regulates HIV-1 Tat-mediated transcription by phosphorylation of CDK9 at position Ser90 and decreases 7SK RNA levels PubMed
tat Iron chelators 311 and ICL670 decrease cellular activity of CDK2 and reduce HIV-1 Tat phosphorylation by CDK2 PubMed
tat When expressed in astrocytes, neurons, and non-glial 293T cells, HIV-1 Tat interacts with a number of cell cycle-related proteins including cyclin A, cyclin B, cyclin D3, Cdk2, Cdk4, Cdk1/Cdc2, cdc6, p27, p53, p63, hdlg, and PCNA PubMed
tat Amino acid residues serine 16 and 46 of HIV-1 Tat are phosphorylated by CDK2; mutation of these two residues reduces HIV-1 transcription in cells PubMed
tat HIV-1 Tat 41/44 peptide TAALS from the core domain of Tat inhibits Tat-mediated HIV-1 gene expression and replication by binding the Cdk2/Cyclin E complex and inhibiting the phosphorylation of serine 5 of RNAPII PubMed
tat Cdk2 phosphorylates HIV-1 Tat PubMed
tat Cdk2/cyclin E stimulates Tat-dependent HIV-1 transcription PubMed
tat Tat-mediated phosphorylation of RNA Polymerase C-terminal domain involves dynamic interactions of Cdk2 with Tat amino acids 15-24 and 36-49 and requires cysteine 22 in the activation domain of Tat and amino acids 42-72 of Tat PubMed
tat HIV-1 Tat induces Cdk2 to phosphorylate the RNA Polymerase C-terminal domain PubMed
tat Cdk2 activity is enhanced by HIV-1 Tat expression in Jurkat T cells and is associated with Tat-induced apoptosis PubMed
tat HIV-1 Tat induces Cyclin E-associated cdk activity in lymphocytes, indicating Tat drives cells to the late G1 phase of the cell cycle PubMed
tat HIV-1 Tat induces a G1 arrest in cells of glial origin, leading to a downregulation of cyclin E-Cdk2 kinase activity and phosphorylation of Rb PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
cyclin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cyclin binding IDA
Inferred from Direct Assay
more info
PubMed 
cyclin binding IPI
Inferred from Physical Interaction
more info
PubMed 
cyclin-dependent protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
cyclin-dependent protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cyclin-dependent protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
cyclin-dependent protein serine/threonine kinase activity TAS
Traceable Author Statement
more info
 
contributes_to histone kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
magnesium ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein domain specific binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein serine/threonine kinase activity IGI
Inferred from Genetic Interaction
more info
PubMed 
Process Evidence Code Pubs
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest TAS
Traceable Author Statement
more info
 
DNA repair IEA
Inferred from Electronic Annotation
more info
 
DNA replication TAS
Traceable Author Statement
more info
PubMed 
G1/S transition of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
G1/S transition of mitotic cell cycle TAS
Traceable Author Statement
more info
 
G2/M transition of mitotic cell cycle NAS
Non-traceable Author Statement
more info
PubMed 
G2/M transition of mitotic cell cycle TAS
Traceable Author Statement
more info
 
Ras protein signal transduction IEP
Inferred from Expression Pattern
more info
PubMed 
anaphase-promoting complex-dependent catabolic process TAS
Traceable Author Statement
more info
 
cell division IEA
Inferred from Electronic Annotation
more info
 
cellular response to nitric oxide TAS
Traceable Author Statement
more info
PubMed 
centriole replication IMP
Inferred from Mutant Phenotype
more info
PubMed 
centrosome duplication TAS
Traceable Author Statement
more info
PubMed 
histone phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
meiotic cell cycle TAS
Traceable Author Statement
more info
PubMed 
mitotic G1 DNA damage checkpoint TAS
Traceable Author Statement
more info
PubMed 
negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
peptidyl-serine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of DNA-dependent DNA replication initiation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell population proliferation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of cell population proliferation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
potassium ion transport IEA
Inferred from Electronic Annotation
more info
 
protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of G2/M transition of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of gene silencing IDA
Inferred from Direct Assay
more info
PubMed 
regulation of signal transduction by p53 class mediator TAS
Traceable Author Statement
more info
 
signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
Cajal body IDA
Inferred from Direct Assay
more info
PubMed 
X chromosome IEA
Inferred from Electronic Annotation
more info
 
Y chromosome IEA
Inferred from Electronic Annotation
more info
 
centrosome IDA
Inferred from Direct Assay
more info
 
centrosome TAS
Traceable Author Statement
more info
PubMed 
chromosome, telomeric region IEA
Inferred from Electronic Annotation
more info
 
condensed chromosome IEA
Inferred from Electronic Annotation
more info
 
cyclin A1-CDK2 complex IDA
Inferred from Direct Assay
more info
PubMed 
cyclin A2-CDK2 complex IDA
Inferred from Direct Assay
more info
PubMed 
cyclin E1-CDK2 complex IDA
Inferred from Direct Assay
more info
PubMed 
cyclin E2-CDK2 complex IDA
Inferred from Direct Assay
more info
PubMed 
cyclin-dependent protein kinase holoenzyme complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cyclin-dependent protein kinase holoenzyme complex IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
endosome IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
transcription regulator complex IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
cyclin-dependent kinase 2
Names
cdc2-related protein kinase
cell division protein kinase 2
p33 protein kinase
NP_001277159.1
NP_001789.2
NP_439892.2
XP_011536034.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_034014.1 RefSeqGene

    Range
    5062..11021
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001290230.2NP_001277159.1  cyclin-dependent kinase 2 isoform 3

    See identical proteins and their annotated locations for NP_001277159.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks two alternate in-frame exons, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
    Source sequence(s)
    AA789250, AK293246, BC003065, DA814453
    Consensus CDS
    CCDS76567.1
    UniProtKB/Swiss-Prot
    P24941
    UniProtKB/TrEMBL
    B4DDL9, E7ESI2
    Related
    ENSP00000393605.2, ENST00000440311.6
    Conserved Domains (1) summary
    cl21453
    Location:3226
    PKc_like; Protein Kinases, catalytic domain
  2. NM_001798.5NP_001789.2  cyclin-dependent kinase 2 isoform 1

    See identical proteins and their annotated locations for NP_001789.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AA789250, AK291941, BC003065, DA814453
    Consensus CDS
    CCDS8898.1
    UniProtKB/Swiss-Prot
    P24941
    UniProtKB/TrEMBL
    A0A024RB77
    Related
    ENSP00000266970.4, ENST00000266970.9
    Conserved Domains (1) summary
    cd07860
    Location:3286
    STKc_CDK2_3; Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase 2 and 3
  3. NM_052827.4NP_439892.2  cyclin-dependent kinase 2 isoform 2

    See identical proteins and their annotated locations for NP_439892.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2, also known as CDK2deltaT) lacks an alternate in-frame exon, compared to variant 1. The encoded isoform (2, also known as d-HSCDK2) is shorter than isoform 1.
    Source sequence(s)
    AA789250, AB012305, BC003065, DA814453
    Consensus CDS
    CCDS8899.1
    UniProtKB/Swiss-Prot
    P24941
    UniProtKB/TrEMBL
    A0A024RB10
    Related
    ENSP00000243067.4, ENST00000354056.4
    Conserved Domains (1) summary
    cl21453
    Location:3252
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    55966830..55972789
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011537732.2XP_011536034.1  cyclin-dependent kinase 2 isoform X1

    See identical proteins and their annotated locations for XP_011536034.1

    UniProtKB/TrEMBL
    G3V5T9
    Related
    ENSP00000452514.1, ENST00000553376.5
    Conserved Domains (1) summary
    cd07860
    Location:3334
    STKc_CDK2_3; Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase 2 and 3
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