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FAT3 FAT atypical cadherin 3 [ Homo sapiens (human) ]

Gene ID: 120114, updated on 8-May-2016
Official Symbol
FAT3provided by HGNC
Official Full Name
FAT atypical cadherin 3provided by HGNC
Primary source
HGNC:HGNC:23112
See related
Ensembl:ENSG00000165323 MIM:612483; Vega:OTTHUMG00000154468
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
hFat3; CDHF15; CDHR10
Orthologs
Location:
11q14.3
Exon count:
29
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 11 NC_000011.10 (92314283..92896470)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (92047446..92629636)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105369429 Neighboring gene ribosomal protein L7a pseudogene 57 Neighboring gene NADH:ubiquinone oxidoreductase subunit B11 pseudogene 1 Neighboring gene phosphoglycerate mutase 1 pseudogene 9 Neighboring gene ribosomal protein S3a pseudogene 42 Neighboring gene uncharacterized LOC105369430 Neighboring gene uncharacterized LOC105369431 Neighboring gene eukaryotic translation elongation factor 1 alpha 2 pseudogene Neighboring gene melatonin receptor 1B

NHGRI GWAS Catalog

Description
Genome-wide association study combining pathway analysis for typical sporadic amyotrophic lateral sclerosis in Chinese Han populations.
NHGRI GWA Catalog
Genome-wide contribution of genotype by environment interaction to variation of diabetes-related traits.
NHGRI GWA Catalog
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ30341, KIAA1989

Gene Ontology Provided by GOA

Function Evidence Code Pubs
calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
homophilic cell adhesion via plasma membrane adhesion molecules IEA
Inferred from Electronic Annotation
more info
 
multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
protocadherin Fat 3
Names
FAT tumor suppressor homolog 3
cadherin family member 15
cadherin-related family member 10

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001008781.2NP_001008781.2  protocadherin Fat 3 precursor

    Status: VALIDATED

    Source sequence(s)
    AB076400, AP000722, AP000805, AP002514, AP003171, AP003718, CN295176
    UniProtKB/Swiss-Prot
    Q8TDW7
    Related
    ENSP00000387040, ENST00000409404
    Conserved Domains (4) summary
    cd11304
    Location:32413337
    Cadherin_repeat; Cadherin tandem repeat domain
    cd00054
    Location:40234058
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00110
    Location:38373992
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    cl15786
    Location:286357
    CA_like; Cadherin repeat-like domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p2 Primary Assembly

    Range
    92314283..92896470
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011542584.1XP_011540886.1  

    Related
    ENSP00000432586, OTTHUMP00000205760, ENST00000525166, OTTHUMT00000335363
    Conserved Domains (4) summary
    cd11304
    Location:32793375
    Cadherin_repeat; Cadherin tandem repeat domain
    cd00054
    Location:40614096
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00110
    Location:38754030
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    cl15786
    Location:301372
    CA_like; Cadherin repeat-like domain

Alternate CHM1_1.1

Genomic

  1. NC_018922.2 Alternate CHM1_1.1

    Range
    91968261..92512715
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)