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Oxr1 oxidation resistance 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 117520, updated on 17-Aug-2024

Summary

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Official Symbol
Oxr1provided by RGD
Official Full Name
oxidation resistance 1provided by RGD
Primary source
RGD:621857
See related
EnsemblRapid:ENSRNOG00000056487 AllianceGenome:RGD:621857
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable oxidoreductase activity. Predicted to be involved in response to oxidative stress. Predicted to act upstream of or within several processes, including adult walking behavior; negative regulation of neuron death; and negative regulation of peptidyl-cysteine S-nitrosylation. Located in nucleolus. Human ortholog(s) of this gene implicated in cerebellar hyplasia/atrophy, epilepsy, and global developmental delay. Orthologous to human OXR1 (oxidation resistance 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Adrenal (RPKM 675.8), Brain (RPKM 506.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
7q31
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (74413609..74850487)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (72528750..72965666)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (80351774..80788094)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120093645 Neighboring gene uncharacterized LOC102556196 Neighboring gene ribosomal protein L31, pseudogene 4 Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC120093810 Neighboring gene small nucleolar RNA, H/ACA box 4 Neighboring gene actin-binding Rho activating protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Contribution of reactive oxygen species via the OXR1 signaling pathway in the pathogenesis of monocrotaline-induced pulmonary arterial hypertension: The protective role of Crocin. Dianat M, et al. Life Sci, 2020 Sep 1. PMID 32585243
  2. Orexin type-1 receptor inhibition in the rat lateral paragigantocellularis nucleus attenuates development of morphine dependence. Rezaei Z, et al. Neurosci Lett, 2020 Apr 17. PMID 32114118
  3. Increased training compensates for OX1R blockage-impairment of spatial memory and c-Fos expression in different cortical and subcortical areas. García-Brito S, et al. Behav Brain Res, 2018 Nov 1. PMID 29953904
  4. MicroRNA-365 Knockdown Prevents Ischemic Neuronal Injury by Activating Oxidation Resistance 1-Mediated Antioxidant Signals. Mo JL, et al. Neurosci Bull, 2019 Oct. PMID 30977043, Free PMC Article
  5. Oxr1 is essential for protection against oxidative stress-induced neurodegeneration. Oliver PL, et al. PLoS Genet, 2011 Oct. PMID 22028674, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Orexin type-1 receptor inhibition in the rat lateral paragigantocellularis nucleus attenuates development of morphine dependence.
    Title: Orexin type-1 receptor inhibition in the rat lateral paragigantocellularis nucleus attenuates development of morphine dependence.
  2. Contribution of reactive oxygen species via the OXR1 signaling pathway in the pathogenesis of monocrotaline-induced pulmonary arterial hypertension: The protective role of Crocin.
    Title: Contribution of reactive oxygen species via the OXR1 signaling pathway in the pathogenesis of monocrotaline-induced pulmonary arterial hypertension: The protective role of Crocin.
  3. MicroRNA-365 up-regulation increases oxidative injury by inhibiting OXR1 expression, while its down-regulation protects neurons from oxidative death by enhancing OXR1-mediated antioxidant signals.
    Title: MicroRNA-365 Knockdown Prevents Ischemic Neuronal Injury by Activating Oxidation Resistance 1-Mediated Antioxidant Signals.
  4. Results showed a deteriorating effect of OXR1 blockade on spatial memory consolidation in the Morris Water Maze, and that increased training is able to counteract such an effect. Additionally, although c-Fos expression cannot be linked to specific neuronal function, the c-Fos data seem to reproduce the behavioural results in a set of regions which have been linked to spatial memory.
    Title: Increased training compensates for OX1R blockage-impairment of spatial memory and c-Fos expression in different cortical and subcortical areas.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Clone Names

  • MGC93253, MGC114530

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in adult walking behavior IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within adult walking behavior ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to hydroperoxide IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cellular response to hydroperoxide ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cellular response to oxidative stress IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of cellular response to oxidative stress ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of neuron apoptotic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of peptidyl-cysteine S-nitrosylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of peptidyl-cysteine S-nitrosylation ISO
Inferred from Sequence Orthology
more info
  
involved_in neuron apoptotic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in response to oxidative stress IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to oxidative stress TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
oxidation resistance protein 1
Names
protein C7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001197332.2 → NP_001184261.1  oxidation resistance protein 1 isoform 3

    See identical proteins and their annotated locations for NP_001184261.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks multiple 5' exons and an internal exon, but has an alternate 5' exon, compared to variant 1. The resulting isoform (3) is much shorter and has a distinct N-terminus, as compared to isoform 1.
    Source sequence(s)
    JAXUCZ010000007
    UniProtKB/TrEMBL
    A6HR95
    Conserved Domains (1) summary
    smart00584
    Location:54 → 216
    TLDc; domain in TBC and LysM domain containing proteins

  2. NM_001197907.2 → NP_001184836.1  oxidation resistance protein 1 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    JAXUCZ010000007
    UniProtKB/TrEMBL
    A0A0G2K7Y2, A0A8I5ZX45
    Related
    ENSRNOP00000074393.1, ENSRNOT00000081948.3
    Conserved Domains (2) summary
    smart00584
    Location:711 → 873
    TLDc; domain in TBC and LysM domain containing proteins
    pfam01476
    Location:100 → 142
    LysM; LysM domain

  3. NM_001414906.1 → NP_001401835.1  oxidation resistance protein 1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000007

  4. NM_057153.5 → NP_476494.3  oxidation resistance protein 1 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks a few of 5' exons and an internal exon, but has an alternate 5' exon, compared to variant 1. The resulting isoform (2) is shorter at the N-terminus, as compared to isoform 1.
    Source sequence(s)
    JAXUCZ010000007
    UniProtKB/Swiss-Prot
    B2RYF9, Q4V8B0, Q99MK0
    UniProtKB/TrEMBL
    A0A0G2JZ50
    Related
    ENSRNOP00000070910.2, ENSRNOT00000091355.3

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    74413609..74850487
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017594617.3 → XP_017450106.1  oxidation resistance protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A0G2JYS1
    Related
    ENSRNOP00000095211.2, ENSRNOT00000098283.2

  2. XM_063262910.1 → XP_063118980.1  oxidation resistance protein 1 isoform X4

    UniProtKB/TrEMBL
    A0A8I5ZX45
    Related
    ENSRNOP00000099353.1, ENSRNOT00000155577.1

  3. XM_063262909.1 → XP_063118979.1  oxidation resistance protein 1 isoform X2

    UniProtKB/TrEMBL
    A0A0G2K7Y2, A0A8I5ZX45

  4. XM_063262911.1 → XP_063118981.1  oxidation resistance protein 1 isoform X4

    UniProtKB/TrEMBL
    A0A8I5ZX45
    Related
    ENSRNOP00000070768.3, ENSRNOT00000084940.3

  5. XM_039078303.1 → XP_038934231.1  oxidation resistance protein 1 isoform X12

    Conserved Domains (1) summary
    pfam01476
    Location:12 → 54
    LysM; LysM domain

  6. XM_063262913.1 → XP_063118983.1  oxidation resistance protein 1 isoform X9

    UniProtKB/TrEMBL
    A0A8I5Y9F4, A0A8I6A1T7

  7. XM_063262912.1 → XP_063118982.1  oxidation resistance protein 1 isoform X8

    UniProtKB/TrEMBL
    A0A8I5Y9F4

  8. XM_017594621.2 → XP_017450110.2  oxidation resistance protein 1 isoform X5

    UniProtKB/TrEMBL
    A0A8I5Y9F4, A0A8I6GLI4
    Conserved Domains (2) summary
    smart00584
    Location:644 → 806
    TLDc; domain in TBC and LysM domain containing proteins
    pfam01476
    Location:33 → 75
    LysM; LysM domain

  9. XM_017594624.3 → XP_017450113.2  oxidation resistance protein 1 isoform X3

    UniProtKB/TrEMBL
    A0A0G2JZ50
    Related
    ENSRNOP00000075440.2, ENSRNOT00000078354.3
    Conserved Domains (2) summary
    smart00584
    Location:704 → 866
    TLDc; domain in TBC and LysM domain containing proteins
    pfam01476
    Location:93 → 135
    LysM; LysM domain

  10. XM_063262915.1 → XP_063118985.1  oxidation resistance protein 1 isoform X11

    UniProtKB/TrEMBL
    A0A0G2KAL4, A0A8I5Y9F4
    Related
    ENSRNOP00000077275.1, ENSRNOT00000099739.2

  11. XM_039078302.2 → XP_038934230.1  oxidation resistance protein 1 isoform X7

    UniProtKB/TrEMBL
    A0A8I5Y9F4, A6HR94
    Conserved Domains (2) summary
    smart00584
    Location:623 → 785
    TLDc; domain in TBC and LysM domain containing proteins
    pfam01476
    Location:12 → 54
    LysM; LysM domain

  12. XM_017594623.3 → XP_017450112.1  oxidation resistance protein 1 isoform X6

    UniProtKB/TrEMBL
    A0A8I5Y9F4

  13. XM_063262914.1 → XP_063118984.1  oxidation resistance protein 1 isoform X10

    UniProtKB/TrEMBL
    A0A8I5Y9F4, A0A8I6AHK4

  14. XM_039078301.2 → XP_038934229.1  oxidation resistance protein 1 isoform X7

    UniProtKB/TrEMBL
    A0A8I5Y9F4, A6HR94
    Conserved Domains (2) summary
    smart00584
    Location:623 → 785
    TLDc; domain in TBC and LysM domain containing proteins
    pfam01476
    Location:12 → 54
    LysM; LysM domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q4V8B0.3 GenPept UniProtKB/Swiss-Prot:Q4V8B0

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