U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Oxr1 oxidation resistance 1 [ Mus musculus (house mouse) ]

Gene ID: 170719, updated on 26-Sep-2022

Summary

Official Symbol
Oxr1provided by MGI
Official Full Name
oxidation resistance 1provided by MGI
Primary source
MGI:MGI:2179326
See related
Ensembl:ENSMUSG00000022307 AllianceGenome:MGI:2179326
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
C7; C7B; 2210416C20Rik
Summary
Enables oxidoreductase activity. Acts upstream of or within several processes, including adult walking behavior; negative regulation of neuron death; and negative regulation of peptidyl-cysteine S-nitrosylation. Located in nucleolus. Is expressed in several structures, including central nervous system; genitourinary system; liver; lung; and spleen. Human ortholog(s) of this gene implicated in cerebellar hyplasia/atrophy, epilepsy, and global developmental delay. Orthologous to human OXR1 (oxidation resistance 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in frontal lobe adult (RPKM 11.8), cerebellum adult (RPKM 10.3) and 24 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Oxr1 in Genome Data Viewer
Location:
15; 15 B3.1
Exon count:
25
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (41310745..41724447)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (41447482..41861051)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 33557 Neighboring gene predicted gene, 41312 Neighboring gene predicted gene, 26854 Neighboring gene actin-binding Rho activating protein Neighboring gene heterogeneous nuclear ribonucleoprotein A3 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC103081, MGC107466

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables oxidoreductase activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in mitochondrion HDA PubMed 
located_in nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
oxidation resistance protein 1
Names
nucleolar protein C7
protein C7

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001130163.1NP_001123635.1  oxidation resistance protein 1 isoform B

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has multiple differences in the coding region and 5' UTR, compared to variant 5, resulting in a protein (isoform B) with a shorter, distinct N-terminus and a missing region in the C-terminus, compared to isoform E.
    Source sequence(s)
    AC129212, AF324899, AF333985, AK158703
    Consensus CDS
    CCDS49600.1
    UniProtKB/Swiss-Prot
    Q4KMM3
    Related
    ENSMUSP00000087553.6, ENSMUST00000090095.13
    Conserved Domains (3) summary
    smart00584
    Location:589751
    TLDc; domain in TBC and LysM domain containing proteins
    COG1388
    Location:1254
    LysM; LysM repeat [Cell wall/membrane/envelope biogenesis]
    pfam01476
    Location:1254
    LysM; LysM domain
  2. NM_001130164.1NP_001123636.1  oxidation resistance protein 1 isoform C

    See identical proteins and their annotated locations for NP_001123636.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) has multiple differences in the coding region and 5' UTR, compared to variant 5, resulting in a protein (isoform C) with a shorter, distinct N-terminus and a missing region in the C-terminus, compared to isoform E.
    Source sequence(s)
    AF333985, AK158703, AW106090, BK006239
    Consensus CDS
    CCDS49601.1
    UniProtKB/Swiss-Prot
    Q4KMM3
    UniProtKB/TrEMBL
    A0A8C6N5B0, B1H3M0
    Related
    ENSMUSP00000130456.2, ENSMUST00000166917.3
    Conserved Domains (1) summary
    smart00584
    Location:54216
    TLDc; domain in TBC and LysM domain containing proteins
  3. NM_001130165.2NP_001123637.1  oxidation resistance protein 1 isoform D

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) has multiple differences in the coding region and 5' UTR, compared to variant 5, resulting in a protein (isoform D) with a shorter, distinct N-terminus and a missing region in the C-terminus, compared to isoform E.
    Source sequence(s)
    AC129212
    Consensus CDS
    CCDS49599.1
    UniProtKB/Swiss-Prot
    Q4KMM3
    UniProtKB/TrEMBL
    E9Q0A7
    Related
    ENSMUSP00000126266.2, ENSMUST00000170127.9
    Conserved Domains (3) summary
    smart00584
    Location:670832
    TLDc; domain in TBC and LysM domain containing proteins
    COG1388
    Location:52135
    LysM; LysM repeat [Cell wall/membrane/envelope biogenesis]
    pfam01476
    Location:93135
    LysM; LysM domain
  4. NM_001130166.1NP_001123638.1  oxidation resistance protein 1 isoform E

    See identical proteins and their annotated locations for NP_001123638.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) encodes the longest isoform (E). Variants 5 and 7 encode the same protein.
    Source sequence(s)
    AF333985, AK158703, BE988908
    Consensus CDS
    CCDS49598.1
    UniProtKB/Swiss-Prot
    Q4KMM3, Q99MP4
    Related
    ENSMUSP00000105926.3, ENSMUST00000110297.10
    Conserved Domains (3) summary
    smart00584
    Location:704866
    TLDc; domain in TBC and LysM domain containing proteins
    pfam01476
    Location:100142
    LysM; LysM domain
    cl26761
    Location:265549
    MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
  5. NM_001358976.1NP_001345905.1  oxidation resistance protein 1 isoform F

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) lacks an alternate exon in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 5. The encoded isoform (F) has a distinct N-terminus and is shorter than isoform E.
    Source sequence(s)
    AC129212
    Conserved Domains (3) summary
    smart00584
    Location:697859
    TLDc; domain in TBC and LysM domain containing proteins
    pfam01476
    Location:93135
    LysM; LysM domain
    pfam09726
    Location:257540
    Macoilin; Transmembrane protein
  6. NM_001358977.1NP_001345906.1  oxidation resistance protein 1 isoform E

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR compared to variant 5. Variants 5 and 7 encode the same protein.
    Source sequence(s)
    AC118590, AC129212, AC141481, AC164633
    Consensus CDS
    CCDS49598.1
    UniProtKB/Swiss-Prot
    Q99MP4
    Conserved Domains (3) summary
    smart00584
    Location:704866
    TLDc; domain in TBC and LysM domain containing proteins
    pfam01476
    Location:100142
    LysM; LysM domain
    cl26761
    Location:265549
    MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
  7. NM_001358978.1NP_001345907.1  oxidation resistance protein 1 isoform G

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) lacks an exon in the coding region, compared to variant 1. The encoded isoform (G) is shorter, compared to isoform E.
    Source sequence(s)
    AC118590, AC129212, AC141481, AC164633
    Consensus CDS
    CCDS88760.1
    Related
    ENSMUSP00000155237.2, ENSMUST00000230203.2
    Conserved Domains (3) summary
    smart00584
    Location:677839
    TLDc; domain in TBC and LysM domain containing proteins
    pfam01476
    Location:100142
    LysM; LysM domain
    cl26761
    Location:265549
    MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
  8. NM_130885.2NP_570955.1  oxidation resistance protein 1 isoform A

    See identical proteins and their annotated locations for NP_570955.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) has multiple differences in the coding region and 5' UTR, compared to variant 5, resulting in a protein (isoform A) with a shorter and distinct N-terminus, compared to isoform E.
    Source sequence(s)
    AC129212
    Consensus CDS
    CCDS27448.1
    UniProtKB/Swiss-Prot
    Q4KMM3
    Related
    ENSMUSP00000022918.8, ENSMUST00000022918.15
    Conserved Domains (3) summary
    smart00584
    Location:616778
    TLDc; domain in TBC and LysM domain containing proteins
    COG1388
    Location:1254
    LysM; LysM repeat [Cell wall/membrane/envelope biogenesis]
    pfam01476
    Location:1254
    LysM; LysM domain

RNA

  1. NR_152565.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9) contains an alternate internal exon, compared to variant 5. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC118590, AC129212, AC141481, AC164633

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    41310745..41724447
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036159205.1XP_036015098.1  oxidation resistance protein 1 isoform X2

    Conserved Domains (3) summary
    smart00584
    Location:690852
    TLDc; domain in TBC and LysM domain containing proteins
    COG5271
    Location:278562
    MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
    pfam01476
    Location:113155
    LysM; LysM domain
  2. XM_030248362.2XP_030104222.1  oxidation resistance protein 1 isoform X4

    Conserved Domains (3) summary
    smart00584
    Location:635797
    TLDc; domain in TBC and LysM domain containing proteins
    COG5271
    Location:196480
    MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
    pfam01476
    Location:3173
    LysM; LysM domain
  3. XM_036159206.1XP_036015099.1  oxidation resistance protein 1 isoform X4

    Conserved Domains (3) summary
    smart00584
    Location:635797
    TLDc; domain in TBC and LysM domain containing proteins
    COG5271
    Location:196480
    MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
    pfam01476
    Location:3173
    LysM; LysM domain
  4. XM_036159204.1XP_036015097.1  oxidation resistance protein 1 isoform X1

    Conserved Domains (3) summary
    smart00584
    Location:717879
    TLDc; domain in TBC and LysM domain containing proteins
    COG5271
    Location:278562
    MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
    pfam01476
    Location:113155
    LysM; LysM domain
  5. XM_036159207.1XP_036015100.1  oxidation resistance protein 1 isoform X5

    Conserved Domains (3) summary
    smart00584
    Location:608770
    TLDc; domain in TBC and LysM domain containing proteins
    COG5271
    Location:196480
    MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
    pfam01476
    Location:3173
    LysM; LysM domain
  6. XM_036159209.1XP_036015102.1  oxidation resistance protein 1 isoform X6

    Related
    ENSMUSP00000155161.2, ENSMUST00000230778.2
    Conserved Domains (2) summary
    COG5271
    Location:278562
    MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
    pfam01476
    Location:113155
    LysM; LysM domain
  7. XM_006520526.5XP_006520589.1  oxidation resistance protein 1 isoform X3

    Conserved Domains (3) summary
    smart00584
    Location:637799
    TLDc; domain in TBC and LysM domain containing proteins
    COG5271
    Location:198482
    MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
    pfam01476
    Location:3375
    LysM; LysM domain
  8. XM_006520531.3XP_006520594.1  oxidation resistance protein 1 isoform X7

    UniProtKB/TrEMBL
    A0A8C6IJ16
    Related
    ENSMUSP00000155424.2, ENSMUST00000230131.2
    Conserved Domains (1) summary
    smart00584
    Location:81243
    TLDc; domain in TBC and LysM domain containing proteins

RNA

  1. XR_004938803.1 RNA Sequence

  2. XR_004938802.1 RNA Sequence

  3. XR_001781499.2 RNA Sequence

  4. XR_004938804.1 RNA Sequence