U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Il17b interleukin 17B [ Rattus norvegicus (Norway rat) ]

Gene ID: 116472, updated on 11-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Il17bprovided by RGD
Official Full Name
interleukin 17Bprovided by RGD
Primary source
RGD:620614
See related
Ensembl:ENSRNOG00000019695 AllianceGenome:RGD:620614
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable cytokine activity. Predicted to be involved in inflammatory response and signal transduction. Predicted to act upstream of or within positive regulation of cytokine production involved in inflammatory response. Predicted to be located in extracellular space. Orthologous to human IL17B (interleukin 17B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 3.9), Uterus (RPKM 1.4) and 5 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Il17b in Genome Data Viewer
Location:
18q12.1
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (57411532..57415903)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (55141194..55145565)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (57011575..57016009)

Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene cardiac mesoderm enhancer-associated non-coding RNA Neighboring gene microRNA 145 Neighboring gene microRNA 143 Neighboring gene prenylcysteine oxidase 1 like Neighboring gene uncharacterized LOC134482948 Neighboring gene GrpE-like 2, mitochondrial

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Cloning and characterization of IL-17B and IL-17C, two new members of the IL-17 cytokine family. Li H, et al. Proc Natl Acad Sci U S A, 2000 Jan 18. PMID 10639155, Free PMC Article
  2. IL-17B and IL-17C are associated with TNF-alpha production and contribute to the exacerbation of inflammatory arthritis. Yamaguchi Y, et al. J Immunol, 2007 Nov 15. PMID 17982105

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables cytokine activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in inflammatory response IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of cytokine production involved in inflammatory response ISO
Inferred from Sequence Orthology
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within signal transduction ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
interleukin-17B

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053789.1 → NP_446241.1  interleukin-17B precursor

    See identical proteins and their annotated locations for NP_446241.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000018
    UniProtKB/TrEMBL
    A6IXI4, G3V8K9
    Related
    ENSRNOP00000026679.5, ENSRNOT00000026679.7
    Conserved Domains (1) summary
    pfam06083
    Location:96 → 179
    IL17; Interleukin-17

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086036.1 Reference GRCr8

    Range
    57411532..57415903
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039096543.1 → XP_038952471.1  interleukin-17B isoform X1

    UniProtKB/TrEMBL
    A6IXI5, Q9EQI7
    Conserved Domains (1) summary
    pfam06083
    Location:38 → 121
    IL17; Interleukin-17

  2. XM_039096542.2 → XP_038952470.1  interleukin-17B isoform X1

    UniProtKB/TrEMBL
    A6IXI5, Q9EQI7
    Conserved Domains (1) summary
    pfam06083
    Location:38 → 121
    IL17; Interleukin-17
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools