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IL17B interleukin 17B [ Homo sapiens (human) ]

Gene ID: 27190, updated on 15-Apr-2019

Summary

Official Symbol
IL17Bprovided by HGNC
Official Full Name
interleukin 17Bprovided by HGNC
Primary source
HGNC:HGNC:5982
See related
Ensembl:ENSG00000127743 MIM:604627
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NIRF; IL-20; IL-17B; ZCYTO7
Summary
The protein encoded by this gene is a T cell-derived cytokine that shares sequence similarity with IL17. This cytokine was reported to stimulate the release of TNF alpha (TNF) and IL1 beta (IL1B) from a monocytic cell line. Immunohistochemical analysis of several nerve tissues indicated that this cytokine is primarily localized to neuronal cell bodies. Alternative splicing results in multiple splice variants. [provided by RefSeq, Dec 2015]
Expression
Low expression observed in reference dataset See more
Orthologs

Genomic context

See IL17B in Genome Data Viewer
Location:
5q32
Exon count:
7
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 5 NC_000005.10 (149374267..149404202, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (148753830..148760848, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene actin filament associated protein 1 like 1 Neighboring gene GRPEL2 antisense RNA 1 Neighboring gene GrpE like 2, mitochondrial Neighboring gene prenylcysteine oxidase 1 like Neighboring gene uncharacterized LOC101927046 Neighboring gene VISTA enhancer hs1752 Neighboring gene cardiac mesoderm enhancer-associated non-coding RNA Neighboring gene microRNA 143

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Aryl Hydrocarbon Receptor Pathway, organism-specific biosystem (from WikiPathways)
    Aryl Hydrocarbon Receptor Pathway, organism-specific biosystemThe aryl hydrocarbon receptor (AhR) is a transcription factor (part of the group of nuclear receptors) that responds to the presence of aromatic hydrocarbons. It regulates genes involved xenobiotic m...
  • Cytokine-cytokine receptor interaction, organism-specific biosystem (from KEGG)
    Cytokine-cytokine receptor interaction, organism-specific biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
  • Cytokine-cytokine receptor interaction, conserved biosystem (from KEGG)
    Cytokine-cytokine receptor interaction, conserved biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
  • IL-17 signaling pathway, organism-specific biosystem (from KEGG)
    IL-17 signaling pathway, organism-specific biosystemThe interleukin 17 (IL-17) family, a subset of cytokines consisting of IL-17A-F, plays crucial roles in both acute and chronic inflammatory responses. IL-17A, the hallmark cytokine of the newly defi...
  • IL-17 signaling pathway, conserved biosystem (from KEGG)
    IL-17 signaling pathway, conserved biosystemThe interleukin 17 (IL-17) family, a subset of cytokines consisting of IL-17A-F, plays crucial roles in both acute and chronic inflammatory responses. IL-17A, the hallmark cytokine of the newly defi...
  • IL17 signaling pathway, organism-specific biosystem (from WikiPathways)
    IL17 signaling pathway, organism-specific biosystemInterleukin 17 is a family of cytokines that acts as potent mediators in delayed-type reactions by increasing chemokine production in various tissues to recruit monocytes and neutrophils to the site ...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC138900, MGC138901

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cytokine activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
cell-cell signaling TAS
Traceable Author Statement
more info
PubMed 
immune response TAS
Traceable Author Statement
more info
PubMed 
inflammatory response IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cytokine production involved in inflammatory response IEA
Inferred from Electronic Annotation
more info
 
regulation of signaling receptor activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
extracellular space IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
interleukin-17B
Names
cytokine-like protein ZCYTO7
interleukin 20
interleukin-17 beta
neuronal interleukin-17 related factor

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001317987.1NP_001304916.1  interleukin-17B isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon. The encoded isoform (2) has a shorter N-terminus than isoform 1.
    Source sequence(s)
    AC131025, AF212311, BM826445
    UniProtKB/Swiss-Prot
    Q9UHF5
    Conserved Domains (1) summary
    pfam06083
    Location:44127
    IL17; Interleukin-17
  2. NM_014443.3NP_055258.1  interleukin-17B isoform 1 precursor

    See identical proteins and their annotated locations for NP_055258.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC131025
    Consensus CDS
    CCDS4297.1
    UniProtKB/Swiss-Prot
    Q9UHF5
    Related
    ENSP00000261796.3, ENST00000261796.4
    Conserved Domains (1) summary
    pfam06083
    Location:96179
    IL17; Interleukin-17

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p12 Primary Assembly

    Range
    149374267..149404202 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017009348.1XP_016864837.1  interleukin-17B isoform X2

    Conserved Domains (1) summary
    pfam06083
    Location:44127
    IL17; Interleukin-17
  2. XM_017009347.1XP_016864836.1  interleukin-17B isoform X2

    Conserved Domains (1) summary
    pfam06083
    Location:44127
    IL17; Interleukin-17
  3. XM_011537622.2XP_011535924.1  interleukin-17B isoform X2

    See identical proteins and their annotated locations for XP_011535924.1

    Conserved Domains (1) summary
    pfam06083
    Location:44127
    IL17; Interleukin-17
  4. XM_017009346.1XP_016864835.1  interleukin-17B isoform X1

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