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Stag3 STAG3 cohesin complex component [ Rattus norvegicus (Norway rat) ]

Gene ID: 114522, updated on 17-Aug-2024

Summary

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Official Symbol
Stag3provided by RGD
Official Full Name
STAG3 cohesin complex componentprovided by RGD
Primary source
RGD:621333
See related
EnsemblRapid:ENSRNOG00000001360 AllianceGenome:RGD:621333
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable chromatin binding activity. Predicted to be involved in sister chromatid cohesion. Predicted to act upstream of or within homologous chromosome pairing at meiosis and protein localization to chromosome. Predicted to be located in male germ cell nucleus and nuclear lumen. Predicted to be part of nuclear meiotic cohesin complex. Predicted to be active in chromatin and nucleus. Human ortholog(s) of this gene implicated in primary ovarian insufficiency 8. Orthologous to human STAG3 (stromal antigen 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward (RPKM 296.2) See more
Orthologs
human mouse all
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Genomic context

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Location:
12q11
Exon count:
37
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (22398291..22428548)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (17284677..17314936)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (19599741..19630775)

Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene galactose-3-O-sulfotransferase 4 Neighboring gene glypican 2 Neighboring gene uncharacterized LOC134481272 Neighboring gene PVR related immunoglobulin domain containing Neighboring gene paired immunoglobin like type 2 receptor beta 2 like 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Evaluation of the Stag3 gene and the synaptonemal complex in a rat model (as/as) for male infertility. Bayés M, et al. Mol Reprod Dev, 2001 Nov. PMID 11599053
  2. STAG3, a novel gene encoding a protein involved in meiotic chromosome pairing and location of STAG3-related genes flanking the Williams-Beuren syndrome deletion. Pezzi N, et al. FASEB J, 2000 Mar. PMID 10698974
  3. Identification and molecular characterization of the mammalian α-kleisin RAD21L. Gutiérrez-Caballero C, et al. Cell Cycle, 2011 May 1. PMID 21527826
  4. SYCP2 and SYCP3 are required for cohesin core integrity at diplotene but not for centromere cohesion at the first meiotic division. Kouznetsova A, et al. J Cell Sci, 2005 May 15. PMID 15870106
  5. RAD21L, a novel cohesin subunit implicated in linking homologous chromosomes in mammalian meiosis. Lee J, et al. J Cell Biol, 2011 Jan 24. PMID 21242291, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in establishment of meiotic sister chromatid cohesion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in establishment of meiotic sister chromatid cohesion ISO
Inferred from Sequence Orthology
more info
  
involved_in establishment of meiotic sister chromatid cohesion ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within homologous chromosome pairing at meiosis ISO
Inferred from Sequence Orthology
more info
  
involved_in meiotic cell cycle TAS
Traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within protein localization to chromosome ISO
Inferred from Sequence Orthology
more info
  
involved_in sister chromatid cohesion IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of chromatin IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in condensed nuclear chromosome ISO
Inferred from Sequence Orthology
more info
  
located_in lateral element ISO
Inferred from Sequence Orthology
more info
  
located_in male germ cell nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of meiotic cohesin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of meiotic cohesin complex ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in synaptonemal complex ISO
Inferred from Sequence Orthology
more info
  
located_in synaptonemal complex TAS
Traceable Author Statement
more info
 PubMed 
located_in transverse filament ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
cohesin subunit SA-3
Names
SCC3 homolog 3
cohesin subunit SA-3-like
stromal antigen 3
stromalin-3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053730.1 → NP_446182.1  cohesin subunit SA-3

    See identical proteins and their annotated locations for NP_446182.1

    Status: PROVISIONAL

    Source sequence(s)
    AY027880
    UniProtKB/Swiss-Prot
    Q99M76
    UniProtKB/TrEMBL
    A6KSU8, A6KSU9
    Conserved Domains (1) summary
    pfam08514
    Location:188 → 296
    STAG; STAG domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086030.1 Reference GRCr8

    Range
    22398291..22428548
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006249020.4 → XP_006249082.1  cohesin subunit SA-3 isoform X1

    See identical proteins and their annotated locations for XP_006249082.1

    UniProtKB/Swiss-Prot
    Q99M76
    UniProtKB/TrEMBL
    A6KSU8, A6KSU9
    Related
    ENSRNOP00000103947.1, ENSRNOT00000127131.1
    Conserved Domains (1) summary
    pfam08514
    Location:188 → 296
    STAG; STAG domain

  2. XM_039089018.1 → XP_038944946.1  cohesin subunit SA-3 isoform X2

    UniProtKB/TrEMBL
    A6KSU9
    Related
    ENSRNOP00000110662.1, ENSRNOT00000162804.1
    Conserved Domains (1) summary
    pfam08514
    Location:188 → 296
    STAG; STAG domain

  3. XM_039089015.2 → XP_038944943.1  cohesin subunit SA-3 isoform X1

    UniProtKB/Swiss-Prot
    Q99M76
    UniProtKB/TrEMBL
    A6KSU8, A6KSU9
    Conserved Domains (1) summary
    pfam08514
    Location:188 → 296
    STAG; STAG domain

  4. XM_063270988.1 → XP_063127058.1  cohesin subunit SA-3 isoform X2

    UniProtKB/TrEMBL
    A6KSU9

  5. XM_039089017.2 → XP_038944945.1  cohesin subunit SA-3 isoform X1

    UniProtKB/Swiss-Prot
    Q99M76
    UniProtKB/TrEMBL
    A6KSU8, A6KSU9
    Conserved Domains (1) summary
    pfam08514
    Location:188 → 296
    STAG; STAG domain

  6. XM_039089016.2 → XP_038944944.1  cohesin subunit SA-3 isoform X1

    UniProtKB/Swiss-Prot
    Q99M76
    UniProtKB/TrEMBL
    A6KSU8, A6KSU9
    Related
    ENSRNOP00000041918.4, ENSRNOT00000042006.6
    Conserved Domains (1) summary
    pfam08514
    Location:188 → 296
    STAG; STAG domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99M76.1 GenPept UniProtKB/Swiss-Prot:Q99M76

Gene LinkOut

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