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TIMP3 TIMP metallopeptidase inhibitor 3 [ Neophocaena asiaeorientalis asiaeorientalis (Yangtze finless porpoise) ]

Gene ID: 112391045, updated on 19-Jun-2024

Summary

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Gene symbol
TIMP3
Gene description
TIMP metallopeptidase inhibitor 3
Gene type
protein coding
RefSeq status
MODEL
Organism
Neophocaena asiaeorientalis asiaeorientalis (sub-species: asiaeorientalis)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti; Phocoenidae; Neophocaena
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: Un
Exon count:
5
Annotation release Status Assembly Chr Location
100 current Neophocaena_asiaeorientalis_V1 (GCF_003031525.1) Unplaced Scaffold NW_020175731.1 (290331..347272, complement)

NW_020175731.1Genomic Context describing neighboring genes Neighboring gene protein HP-20 homolog Neighboring gene protein HP-25 homolog 2-like Neighboring gene synapsin III Neighboring gene CDC42 small effector protein 2-like Neighboring gene F-box protein 7

Genomic regions, transcripts, and products

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Genomic Sequence:
NW_020175731 Unplaced Scaffold Reference Neophocaena_asiaeorientalis_V1 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables metalloendopeptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protease binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of membrane protein ectodomain proteolysis IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular matrix IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
metalloproteinase inhibitor 3

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Neophocaena asiaeorientalis asiaeorientalis Annotation Release 100 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Neophocaena_asiaeorientalis_V1 Primary Assembly

Genomic

  1. NW_020175731.1 Reference Neophocaena_asiaeorientalis_V1 Primary Assembly

    Range
    290331..347272 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024732156.1 → XP_024587924.1  metalloproteinase inhibitor 3

    UniProtKB/TrEMBL
    A0A341ADD2
    Conserved Domains (1) summary
    cd03585
    Location:24 → 200
    NTR_TIMP; NTR domain, TIMP subfamily; TIMPs, or tissue inibitors of metalloproteases, are essential regulators of extracellular matrix turnover and remodeling. They form complexes with matrix metalloproteases (MMPs) and inactivate them irreversibly by ...
Nucleotide Protein
Heading Accession and Version

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