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JAK2 Janus kinase 2 [ Neomonachus schauinslandi (Hawaiian monk seal) ]

Gene ID: 110584421, updated on 11-Apr-2024

Summary

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Gene symbol
JAK2
Gene description
Janus kinase 2
See related
EnsemblRapid:ENSNSCG00000016014
Gene type
protein coding
RefSeq status
MODEL
Organism
Neomonachus schauinslandi
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Pinnipedia; Phocidae; Neomonachus
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 13
Exon count:
25
Annotation release Status Assembly Chr Location
101 current ASM220157v2 (GCF_002201575.2) 13 NC_058415.1 (6390704..6539858, complement)
100 previous assembly ASM220157v1 (GCF_002201575.1) Unplaced Scaffold NW_018734353.1 (10545154..10628777)

Chromosome 13 - NC_058415.1Genomic Context describing neighboring genes Neighboring gene 60S ribosomal protein L12-like Neighboring gene 26S proteasome regulatory subunit 10B-like Neighboring gene U6 spliceosomal RNA Neighboring gene splicing factor 3B subunit 4-like Neighboring gene RNA terminal phosphate cyclase like 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables cytokine receptor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables histone binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables non-membrane spanning protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell surface receptor signaling pathway via JAK-STAT IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cytokine-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in hemopoiesis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in peptidyl-tyrosine phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
tyrosine-protein kinase JAK2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Neomonachus schauinslandi Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ASM220157v2

Genomic

  1. NC_058415.1 Reference ASM220157v2

    Range
    6390704..6539858 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021694453.2 → XP_021550128.1  tyrosine-protein kinase JAK2 isoform X1

    UniProtKB/TrEMBL
    A0A2Y9HEH0
    Related
    ENSNSCP00000019916.1
    Conserved Domains (5) summary
    cd10379
    Location:384 → 480
    SH2_Jak2; Src homology 2 (SH2) domain in the Janus kinase 2 (Jak2) proteins
    smart00295
    Location:37 → 268
    B41; Band 4.1 homologues
    cd13333
    Location:264 → 384
    FERM_C_JAK2; FERM domain C-lobe of Janus kinase (JAK) 2
    cd05078
    Location:543 → 804
    PTK_Jak2_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Janus kinase 2
    cd14205
    Location:842 → 1125
    PTKc_Jak2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 2

  2. XM_021694454.2 → XP_021550129.1  tyrosine-protein kinase JAK2 isoform X2

    UniProtKB/TrEMBL
    A0A2Y9HKV9
    Related
    ENSNSCP00000019928.1
    Conserved Domains (5) summary
    cd10379
    Location:384 → 480
    SH2_Jak2; Src homology 2 (SH2) domain in the Janus kinase 2 (Jak2) proteins
    smart00295
    Location:37 → 268
    B41; Band 4.1 homologues
    cd13333
    Location:264 → 384
    FERM_C_JAK2; FERM domain C-lobe of Janus kinase (JAK) 2
    cd05078
    Location:543 → 804
    PTK_Jak2_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Janus kinase 2
    cl21453
    Location:842 → 1087
    PKc_like; Protein Kinases, catalytic domain

  3. XM_021694455.1 → XP_021550130.1  tyrosine-protein kinase JAK2 isoform X3

    UniProtKB/TrEMBL
    A0A2Y9HKP7
    Conserved Domains (5) summary
    cd10379
    Location:384 → 480
    SH2_Jak2; Src homology 2 (SH2) domain in the Janus kinase 2 (Jak2) proteins
    smart00295
    Location:37 → 268
    B41; Band 4.1 homologues
    cd13333
    Location:264 → 384
    FERM_C_JAK2; FERM domain C-lobe of Janus kinase (JAK) 2
    cd05078
    Location:543 → 804
    PTK_Jak2_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Janus kinase 2
    cl21453
    Location:842 → 1057
    PKc_like; Protein Kinases, catalytic domain
Nucleotide Protein
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