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Jak2 Janus kinase 2 [ Mus musculus (house mouse) ]

Gene ID: 16452, updated on 20-Jun-2024

Summary

Official Symbol
Jak2provided by MGI
Official Full Name
Janus kinase 2provided by MGI
Primary source
MGI:MGI:96629
See related
Ensembl:ENSMUSG00000024789 AllianceGenome:MGI:96629
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Fd17
Summary
Enables interleukin-12 receptor binding activity and protein tyrosine kinase activity. Involved in several processes, including hemopoiesis; positive regulation of macromolecule metabolic process; and regulation of signal transduction. Acts upstream of or within several processes, including cell surface receptor signaling pathway; cellular response to lipid; and regulation of apoptotic process. Located in caveola and nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; liver and biliary system; and musculoskeletal system. Used to study essential thrombocythemia; myelofibrosis; myeloproliferative neoplasm; and polycythemia vera. Human ortholog(s) of this gene implicated in several diseases, including gastrointestinal system cancer (multiple); hematologic cancer (multiple); hepatic vascular disease (multiple); inflammatory bowel disease (multiple); and lung non-small cell carcinoma (multiple). Orthologous to human JAK2 (Janus kinase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bladder adult (RPKM 6.6), CNS E18 (RPKM 6.3) and 28 other tissues See more
Orthologs
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Genomic context

See Jak2 in Genome Data Viewer
Location:
19 C1; 19 23.73 cM
Exon count:
28
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (29229006..29290495)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (29251803..29313095)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene RNA terminal phosphate cyclase-like 1 Neighboring gene STARR-seq mESC enhancer starr_45880 Neighboring gene microRNA 101b Neighboring gene predicted gene 5518 Neighboring gene STARR-seq mESC enhancer starr_45881 Neighboring gene STARR-positive B cell enhancer ABC_E11673 Neighboring gene predicted gene, 41829 Neighboring gene STARR-seq mESC enhancer starr_45882 Neighboring gene STARR-seq mESC enhancer starr_45883 Neighboring gene insulin-like 6 Neighboring gene relaxin 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables SH2 domain binding ISO
Inferred from Sequence Orthology
more info
 
enables acetylcholine receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables growth hormone receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables growth hormone receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables heme binding ISO
Inferred from Sequence Orthology
more info
 
enables histone H3Y41 kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables histone binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables insulin receptor substrate binding ISO
Inferred from Sequence Orthology
more info
 
enables interleukin-12 receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables non-membrane spanning protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables non-membrane spanning protein tyrosine kinase activity TAS
Traceable Author Statement
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables peptide hormone receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables phosphatidylinositol 3-kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables protein tyrosine kinase activity EXP
Inferred from Experiment
more info
PubMed 
enables protein tyrosine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein tyrosine kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables protein tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein tyrosine kinase activity TAS
Traceable Author Statement
more info
 
enables signaling receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables type 1 angiotensin receptor binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in activation of Janus kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in activation of cysteine-type endopeptidase activity involved in apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within adaptive immune response IEA
Inferred from Electronic Annotation
more info
 
involved_in axon regeneration ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cell surface receptor signaling pathway via JAK-STAT IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within cell surface receptor signaling pathway via JAK-STAT IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cell surface receptor signaling pathway via JAK-STAT IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within cell surface receptor signaling pathway via JAK-STAT IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cell surface receptor signaling pathway via JAK-STAT ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cellular response to dexamethasone stimulus IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within cellular response to interleukin-3 IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within cellular response to lipopolysaccharide IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within chromatin organization IEA
Inferred from Electronic Annotation
more info
 
involved_in collagen-activated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in cytokine-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cytokine-mediated signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in cytokine-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cytokine-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cytokine-mediated signaling pathway TAS
Traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within enzyme-linked receptor protein signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in erythrocyte differentiation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in erythrocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within extrinsic apoptotic signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in granulocyte-macrophage colony-stimulating factor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in growth hormone receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in growth hormone receptor signaling pathway via JAK-STAT IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in growth hormone receptor signaling pathway via JAK-STAT IDA
Inferred from Direct Assay
more info
PubMed 
involved_in growth hormone receptor signaling pathway via JAK-STAT IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in growth hormone receptor signaling pathway via JAK-STAT ISO
Inferred from Sequence Orthology
more info
 
involved_in hormone-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in immune response NAS
Non-traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within innate immune response IEA
Inferred from Electronic Annotation
more info
 
involved_in interleukin-12-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in interleukin-3-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in interleukin-5-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within intracellular signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
involved_in intrinsic apoptotic signaling pathway in response to oxidative stress ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within mammary gland epithelium development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in microglial cell activation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in modulation of chemical synaptic transmission ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within myeloid cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cardiac muscle cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in nuclear receptor-mediated mineralocorticoid signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within peptidyl-tyrosine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in platelet-derived growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of MHC class II biosynthetic process IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of NK T cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of NK T cell proliferation NAS
Non-traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within positive regulation of SMAD protein signal transduction ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in positive regulation of T cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of T cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of T-helper 17 type immune response NAS
Non-traceable Author Statement
more info
PubMed 
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of apoptotic signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cell activation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell-substrate adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cold-induced thermogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cytosolic calcium ion concentration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of epithelial cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of growth factor dependent skeletal muscle satellite cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of growth hormone receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of insulin secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of interleukin-1 beta production IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of interleukin-1 beta production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of interleukin-17 production NAS
Non-traceable Author Statement
more info
PubMed 
involved_in positive regulation of leukocyte proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of natural killer cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of nitric oxide biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of nitric-oxide synthase biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of nitric-oxide synthase biosynthetic process IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of nitric-oxide synthase biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of platelet activation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of positive regulation of platelet aggregation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein import into nucleus ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of receptor signaling pathway via JAK-STAT ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of signaling receptor activity IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of tumor necrosis factor production IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of tumor necrosis factor production IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of type II interferon production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of tyrosine phosphorylation of STAT protein IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of vascular associated smooth muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in post-embryonic hemopoiesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in post-translational protein modification ISO
Inferred from Sequence Orthology
more info
 
involved_in protein autophosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of inflammatory response ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of nitric oxide biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of postsynapse to nucleus signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within response to antibiotic ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in response to granulocyte macrophage colony-stimulating factor NAS
Non-traceable Author Statement
more info
PubMed 
involved_in response to hydroperoxide ISO
Inferred from Sequence Orthology
more info
 
involved_in response to interleukin-12 ISO
Inferred from Sequence Orthology
more info
 
involved_in response to lipopolysaccharide IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to oxidative stress ISO
Inferred from Sequence Orthology
more info
 
involved_in response to tumor necrosis factor ISO
Inferred from Sequence Orthology
more info
 
involved_in signal transduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within symbiont-induced defense-related programmed cell death IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in tumor necrosis factor-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in type II interferon-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in tyrosine phosphorylation of STAT protein IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within tyrosine phosphorylation of STAT protein IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within tyrosine phosphorylation of STAT protein IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in caveola IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm TAS
Traceable Author Statement
more info
PubMed 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
part_of euchromatin ISO
Inferred from Sequence Orthology
more info
 
is_active_in extrinsic component of cytoplasmic side of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in extrinsic component of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in focal adhesion ISO
Inferred from Sequence Orthology
more info
 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
part_of granulocyte macrophage colony-stimulating factor receptor complex ISO
Inferred from Sequence Orthology
more info
 
part_of interleukin-12 receptor complex NAS
Non-traceable Author Statement
more info
PubMed 
part_of interleukin-23 receptor complex NAS
Non-traceable Author Statement
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane raft IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane NAS
Non-traceable Author Statement
more info
PubMed 
is_active_in postsynapse ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
tyrosine-protein kinase JAK2
Names
JAK-2
NP_001041642.1
NP_032439.2
XP_006526776.1
XP_006526777.1
XP_006526778.1
XP_011245457.1
XP_017173557.1
XP_036017342.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001048177.3NP_001041642.1  tyrosine-protein kinase JAK2

    See identical proteins and their annotated locations for NP_001041642.1

    Status: VALIDATED

    Source sequence(s)
    AC119228, AC162456
    Consensus CDS
    CCDS37950.1
    UniProtKB/Swiss-Prot
    G5E852, Q62120, Q62124, Q7TQD0
    Related
    ENSMUSP00000025705.7, ENSMUST00000025705.7
    Conserved Domains (6) summary
    cd10379
    Location:386482
    SH2_Jak2; Src homology 2 (SH2) domain in the Janus kinase 2 (Jak2) proteins
    cd13333
    Location:266386
    FERM_C_JAK2; FERM domain C-lobe of Janus kinase (JAK) 2
    cd05078
    Location:545806
    PTK_Jak2_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Janus kinase 2
    cd14205
    Location:8441127
    PTKc_Jak2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 2
    pfam18377
    Location:143261
    FERM_F2; FERM F2 acyl-CoA binding protein-like domain
    pfam18379
    Location:39134
    FERM_F1; FERM F1 ubiquitin-like domain
  2. NM_008413.4NP_032439.2  tyrosine-protein kinase JAK2

    See identical proteins and their annotated locations for NP_032439.2

    Status: VALIDATED

    Source sequence(s)
    AC119228, AC162456
    Consensus CDS
    CCDS37950.1
    UniProtKB/Swiss-Prot
    G5E852, Q62120, Q62124, Q7TQD0
    Related
    ENSMUSP00000064394.4, ENSMUST00000065796.10
    Conserved Domains (6) summary
    cd10379
    Location:386482
    SH2_Jak2; Src homology 2 (SH2) domain in the Janus kinase 2 (Jak2) proteins
    cd13333
    Location:266386
    FERM_C_JAK2; FERM domain C-lobe of Janus kinase (JAK) 2
    cd05078
    Location:545806
    PTK_Jak2_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Janus kinase 2
    cd14205
    Location:8441127
    PTKc_Jak2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 2
    pfam18377
    Location:143261
    FERM_F2; FERM F2 acyl-CoA binding protein-like domain
    pfam18379
    Location:39134
    FERM_F1; FERM F1 ubiquitin-like domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    29229006..29290495
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036161449.1XP_036017342.1  tyrosine-protein kinase JAK2 isoform X5

    UniProtKB/TrEMBL
    A0A494BBB9
    Related
    ENSMUSP00000158405.2, ENSMUST00000236990.2
    Conserved Domains (5) summary
    cd10379
    Location:386482
    SH2_Jak2; Src homology 2 (SH2) domain in the Janus kinase 2 (Jak2) proteins
    cd13333
    Location:266386
    FERM_C_JAK2; FERM domain C-lobe of Janus kinase (JAK) 2
    pfam18377
    Location:143261
    FERM_F2; FERM F2 acyl-CoA binding protein-like domain
    pfam18379
    Location:39134
    FERM_F1; FERM F1 ubiquitin-like domain
    cl21453
    Location:545592
    PKc_like; Protein Kinases, catalytic domain
  2. XM_006526715.5XP_006526778.1  tyrosine-protein kinase JAK2 isoform X5

    UniProtKB/TrEMBL
    A0A494BBB9
    Conserved Domains (5) summary
    cd10379
    Location:386482
    SH2_Jak2; Src homology 2 (SH2) domain in the Janus kinase 2 (Jak2) proteins
    cd13333
    Location:266386
    FERM_C_JAK2; FERM domain C-lobe of Janus kinase (JAK) 2
    pfam18377
    Location:143261
    FERM_F2; FERM F2 acyl-CoA binding protein-like domain
    pfam18379
    Location:39134
    FERM_F1; FERM F1 ubiquitin-like domain
    cl21453
    Location:545592
    PKc_like; Protein Kinases, catalytic domain
  3. XM_006526713.5XP_006526776.1  tyrosine-protein kinase JAK2 isoform X2

    Conserved Domains (6) summary
    cd10379
    Location:386482
    SH2_Jak2; Src homology 2 (SH2) domain in the Janus kinase 2 (Jak2) proteins
    cd13333
    Location:266386
    FERM_C_JAK2; FERM domain C-lobe of Janus kinase (JAK) 2
    cd14205
    Location:7991082
    PTKc_Jak2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 2
    pfam18377
    Location:143261
    FERM_F2; FERM F2 acyl-CoA binding protein-like domain
    pfam18379
    Location:39134
    FERM_F1; FERM F1 ubiquitin-like domain
    cl21453
    Location:548761
    PKc_like; Protein Kinases, catalytic domain
  4. XM_011247155.3XP_011245457.1  tyrosine-protein kinase JAK2 isoform X1

    See identical proteins and their annotated locations for XP_011245457.1

    UniProtKB/Swiss-Prot
    G5E852, Q62120, Q62124, Q7TQD0
    Conserved Domains (6) summary
    cd10379
    Location:386482
    SH2_Jak2; Src homology 2 (SH2) domain in the Janus kinase 2 (Jak2) proteins
    cd13333
    Location:266386
    FERM_C_JAK2; FERM domain C-lobe of Janus kinase (JAK) 2
    cd05078
    Location:545806
    PTK_Jak2_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Janus kinase 2
    cd14205
    Location:8441127
    PTKc_Jak2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 2
    pfam18377
    Location:143261
    FERM_F2; FERM F2 acyl-CoA binding protein-like domain
    pfam18379
    Location:39134
    FERM_F1; FERM F1 ubiquitin-like domain
  5. XM_017318068.3XP_017173557.1  tyrosine-protein kinase JAK2 isoform X4

    Conserved Domains (3) summary
    cd05078
    Location:140401
    PTK_Jak2_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Janus kinase 2
    cd14205
    Location:439722
    PTKc_Jak2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 2
    cl15255
    Location:177
    SH2; Src homology 2 (SH2) domain
  6. XM_006526714.5XP_006526777.1  tyrosine-protein kinase JAK2 isoform X3

    Conserved Domains (5) summary
    cd10379
    Location:190286
    SH2_Jak2; Src homology 2 (SH2) domain in the Janus kinase 2 (Jak2) proteins
    cd13333
    Location:70190
    FERM_C_JAK2; FERM domain C-lobe of Janus kinase (JAK) 2
    cd05078
    Location:349610
    PTK_Jak2_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Janus kinase 2
    cd14205
    Location:648931
    PTKc_Jak2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 2
    pfam18377
    Location:1065
    FERM_F2; FERM F2 acyl-CoA binding protein-like domain