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ARHGEF11 Rho guanine nucleotide exchange factor 11 [ Neomonachus schauinslandi (Hawaiian monk seal) ]

Gene ID: 110573537, updated on 15-Mar-2024

Summary

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Gene symbol
ARHGEF11
Gene description
Rho guanine nucleotide exchange factor 11
See related
EnsemblRapid:ENSNSCG00000015943
Gene type
protein coding
RefSeq status
MODEL
Organism
Neomonachus schauinslandi
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Pinnipedia; Phocidae; Neomonachus
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 6
Exon count:
41
Annotation release Status Assembly Chr Location
101 current ASM220157v2 (GCF_002201575.2) 6 NC_058408.1 (2394747..2478845, complement)
100 previous assembly ASM220157v1 (GCF_002201575.1) Unplaced Scaffold NW_018734287.1 (3143525..3228095)

Chromosome 6 - NC_058408.1Genomic Context describing neighboring genes Neighboring gene platelet endothelial aggregation receptor 1 Neighboring gene leucine rich repeat containing 71 Neighboring gene ETS variant transcription factor 3 like Neighboring gene ETS variant transcription factor 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables G protein-coupled receptor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in Rho protein signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
rho guanine nucleotide exchange factor 11

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Neomonachus schauinslandi Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ASM220157v2

Genomic

  1. NC_058408.1 Reference ASM220157v2

    Range
    2394747..2478845 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021682078.1 → XP_021537753.1  rho guanine nucleotide exchange factor 11 isoform X1

    UniProtKB/TrEMBL
    A0A2Y9GF90
    Related
    ENSNSCP00000019867.1, ENSNSCT00000022457.1
    Conserved Domains (5) summary
    cd08753
    Location:329 → 473
    RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein
    cd00160
    Location:774 → 960
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00992
    Location:45 → 119
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13391
    Location:978 → 1120
    PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
    cl26386
    Location:1116 → 1410
    DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III

  2. XM_021682074.1 → XP_021537749.1  rho guanine nucleotide exchange factor 11 isoform X2

    UniProtKB/TrEMBL
    A0A2Y9GJW9
    Conserved Domains (5) summary
    cd08753
    Location:329 → 473
    RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein
    cd00160
    Location:775 → 961
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00992
    Location:45 → 119
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13391
    Location:979 → 1121
    PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
    cl28033
    Location:1125 → 1380
    Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region

  3. XM_021682077.1 → XP_021537752.1  rho guanine nucleotide exchange factor 11 isoform X3

    UniProtKB/TrEMBL
    A0A2Y9GF98
    Conserved Domains (5) summary
    cd08753
    Location:329 → 473
    RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein
    cd00160
    Location:775 → 961
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00992
    Location:45 → 119
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13391
    Location:979 → 1121
    PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
    cl28033
    Location:1125 → 1380
    Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region
Nucleotide Protein
Heading Accession and Version

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