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ARHGEF11 Rho guanine nucleotide exchange factor 11 [ Homo sapiens (human) ]

Gene ID: 9826, updated on 4-Oct-2020

Summary

Official Symbol
ARHGEF11provided by HGNC
Official Full Name
Rho guanine nucleotide exchange factor 11provided by HGNC
Primary source
HGNC:HGNC:14580
See related
Ensembl:ENSG00000132694 MIM:605708
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GTRAP48; PDZ-RHOGEF
Summary
Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. A similar protein in rat interacts with glutamate transporter EAAT4 and modulates its glutamate transport activity. Expression of the rat protein induces the reorganization of the actin cytoskeleton and its overexpression induces the formation of membrane ruffling and filopodia. Two alternative transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in testis (RPKM 13.2), brain (RPKM 7.8) and 25 other tissues See more
Orthologs

Genomic context

See ARHGEF11 in Genome Data Viewer
Location:
1q23.1
Exon count:
47
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (156934840..157046903, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (156904632..157015512, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene neurotrophic receptor tyrosine kinase 1 Neighboring gene insulin receptor related receptor Neighboring gene platelet endothelial aggregation receptor 1 Neighboring gene leucine rich repeat containing 71 Neighboring gene microRNA 765 Neighboring gene RNA, 7SL, cytoplasmic 612, pseudogene Neighboring gene uncharacterized LOC102724222 Neighboring gene SMU1 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0380, DKFZp667F1223

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G protein-coupled receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
GTPase activator activity IEA
Inferred from Electronic Annotation
more info
 
Rho guanyl-nucleotide exchange factor activity TAS
Traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
rho guanine nucleotide exchange factor 11
Names
Rho guanine exchange factor (GEF) 11
Rho guanine nucleotide exchange factor (GEF) 11
RhoA-specific guanine nucleotide exchange factor
RhoGEF glutamate transport modulator
glutamate transporter EAAT4-associated protein 48

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001377418.1NP_001364347.1  rho guanine nucleotide exchange factor 11 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AL157713, AL356104
  2. NM_001377419.1NP_001364348.1  rho guanine nucleotide exchange factor 11 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AL157713, AL356104
  3. NM_014784.4NP_055599.1  rho guanine nucleotide exchange factor 11 isoform 1

    See identical proteins and their annotated locations for NP_055599.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the predominant isoform (1).
    Source sequence(s)
    AB002378, AL157713, BC057394
    Consensus CDS
    CCDS1162.1
    UniProtKB/Swiss-Prot
    O15085
    Related
    ENSP00000354644.2, ENST00000361409.2
    Conserved Domains (6) summary
    cd08753
    Location:290434
    RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein
    COG0265
    Location:61139
    DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]
    cd00992
    Location:46120
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13391
    Location:9391081
    PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
    pfam00169
    Location:9991079
    PH; PH domain
    pfam00621
    Location:738922
    RhoGEF; RhoGEF domain
  4. NM_198236.3NP_937879.1  rho guanine nucleotide exchange factor 11 isoform 2

    See identical proteins and their annotated locations for NP_937879.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternate in-frame exon, compared to variant 1. The resulting protein (isoform 2) is longer, compared to isoform 1.
    Source sequence(s)
    AL157713, BC057394
    Consensus CDS
    CCDS1163.1
    UniProtKB/Swiss-Prot
    O15085
    Related
    ENSP00000357177.3, ENST00000368194.7
    Conserved Domains (6) summary
    cd08753
    Location:330474
    RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein
    COG0265
    Location:61139
    DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]
    cd00992
    Location:46120
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13391
    Location:9791121
    PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
    pfam00169
    Location:10391119
    PH; PH domain
    pfam00621
    Location:778962
    RhoGEF; RhoGEF domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    156934840..157046903 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017002923.2XP_016858412.1  rho guanine nucleotide exchange factor 11 isoform X13

  2. XM_005245629.5XP_005245686.1  rho guanine nucleotide exchange factor 11 isoform X7

    Conserved Domains (6) summary
    cd08753
    Location:330474
    RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein
    COG0265
    Location:61139
    DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]
    cd00992
    Location:46120
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13391
    Location:9801122
    PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
    pfam00169
    Location:10401120
    PH; PH domain
    pfam00621
    Location:779963
    RhoGEF; RhoGEF domain
  3. XM_017002920.2XP_016858409.1  rho guanine nucleotide exchange factor 11 isoform X5

  4. XM_017002924.2XP_016858413.1  rho guanine nucleotide exchange factor 11 isoform X14

  5. XM_011510185.3XP_011508487.1  rho guanine nucleotide exchange factor 11 isoform X3

    Conserved Domains (6) summary
    cd08753
    Location:341485
    RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein
    COG0265
    Location:72150
    DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]
    cd00992
    Location:57131
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13391
    Location:9911133
    PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
    pfam00169
    Location:10511131
    PH; PH domain
    pfam00621
    Location:790974
    RhoGEF; RhoGEF domain
  6. XM_017002922.2XP_016858411.1  rho guanine nucleotide exchange factor 11 isoform X12

  7. XM_006711665.4XP_006711728.1  rho guanine nucleotide exchange factor 11 isoform X11

    Conserved Domains (6) summary
    cd08753
    Location:306450
    RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein
    COG0265
    Location:77155
    DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]
    cd00992
    Location:62136
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13391
    Location:9551097
    PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
    pfam00169
    Location:10151095
    PH; PH domain
    pfam00621
    Location:754938
    RhoGEF; RhoGEF domain
  8. XM_011510186.3XP_011508488.1  rho guanine nucleotide exchange factor 11 isoform X10

    Conserved Domains (6) summary
    cd08753
    Location:306450
    RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein
    COG0265
    Location:77155
    DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]
    cd00992
    Location:62136
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13391
    Location:9561098
    PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
    pfam00169
    Location:10161096
    PH; PH domain
    pfam00621
    Location:755939
    RhoGEF; RhoGEF domain
  9. XM_006711662.3XP_006711725.1  rho guanine nucleotide exchange factor 11 isoform X6

    Conserved Domains (6) summary
    cd08753
    Location:346490
    RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein
    COG0265
    Location:77155
    DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]
    cd00992
    Location:62136
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13391
    Location:9851127
    PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
    pfam00169
    Location:10451125
    PH; PH domain
    pfam00621
    Location:784968
    RhoGEF; RhoGEF domain
  10. XM_006711660.4XP_006711723.1  rho guanine nucleotide exchange factor 11 isoform X2

    Conserved Domains (6) summary
    cd08753
    Location:346490
    RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein
    COG0265
    Location:77155
    DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]
    cd00992
    Location:62136
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13391
    Location:9951137
    PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
    pfam00169
    Location:10551135
    PH; PH domain
    pfam00621
    Location:794978
    RhoGEF; RhoGEF domain
  11. XM_006711661.3XP_006711724.1  rho guanine nucleotide exchange factor 11 isoform X4

    Conserved Domains (6) summary
    cd08753
    Location:346490
    RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein
    COG0265
    Location:77155
    DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]
    cd00992
    Location:62136
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13391
    Location:9861128
    PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
    pfam00169
    Location:10461126
    PH; PH domain
    pfam00621
    Location:785969
    RhoGEF; RhoGEF domain
  12. XM_006711659.3XP_006711722.1  rho guanine nucleotide exchange factor 11 isoform X1

    Conserved Domains (6) summary
    cd08753
    Location:346490
    RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein
    COG0265
    Location:77155
    DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]
    cd00992
    Location:62136
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13391
    Location:9961138
    PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
    pfam00169
    Location:10561136
    PH; PH domain
    pfam00621
    Location:795979
    RhoGEF; RhoGEF domain
  13. XM_011510187.3XP_011508489.1  rho guanine nucleotide exchange factor 11 isoform X15

    Conserved Domains (5) summary
    cd08753
    Location:252396
    RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein
    smart00228
    Location:242
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd13391
    Location:9021044
    PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
    pfam00169
    Location:9621042
    PH; PH domain
    pfam00621
    Location:701885
    RhoGEF; RhoGEF domain
  14. XM_005245633.4XP_005245690.1  rho guanine nucleotide exchange factor 11 isoform X16

    Conserved Domains (4) summary
    cd13391
    Location:558700
    PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
    pfam00169
    Location:618698
    PH; PH domain
    pfam00621
    Location:357541
    RhoGEF; RhoGEF domain
    cl02565
    Location:2105
    RGS; Regulator of G protein signaling (RGS) domain superfamily
  15. XM_011510189.3XP_011508491.1  rho guanine nucleotide exchange factor 11 isoform X17

    Conserved Domains (3) summary
    cd13391
    Location:362504
    PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
    pfam00169
    Location:422502
    PH; PH domain
    pfam00621
    Location:161345
    RhoGEF; RhoGEF domain
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