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C5 complement C5 [ Numida meleagris (helmeted guineafowl) ]

Gene ID: 110406963, updated on 15-Mar-2024

Summary

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Gene symbol
C5
Gene description
complement C5
See related
Ensembl:ENSNMEG00000009704
Gene type
protein coding
RefSeq status
MODEL
Organism
Numida meleagris
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Numididae; Numida
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 16
Exon count:
41
Annotation release Status Assembly Chr Location
100 current NumMel1.0 (GCF_002078875.1) 16 NC_034424.1 (8153632..8179742, complement)

Chromosome 16 - NC_034424.1Genomic Context describing neighboring genes Neighboring gene PHD finger protein 19 Neighboring gene TNF receptor associated factor 1 Neighboring gene centriolin Neighboring gene RAB14, member RAS oncogene family Neighboring gene gelsolin

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_034424.1 Chromosome 16 Reference NumMel1.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables endopeptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
complement C5

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Numida meleagris Annotation Release 100 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference NumMel1.0 Primary Assembly

Genomic

  1. NC_034424.1 Reference NumMel1.0 Primary Assembly

    Range
    8153632..8179742 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021414082.1 → XP_021269757.1  complement C5 isoform X1

    Related
    ENSNMEP00000012118.1, ENSNMET00000018902.1
    Conserved Domains (7) summary
    cd00017
    Location:651 → 715
    ANATO; Anaphylatoxin homologous domain; C3a, C4a and C5a anaphylatoxins are protein fragments generated enzymatically in serum during activation of complement molecules C3, C4, and C5. They induce smooth muscle contraction. These fragments are homologous to ...
    cd02896
    Location:957 → 1264
    complement_C3_C4_C5; Proteins similar to C3, C4 and C5 of vertebrate complement. The vertebrate complement system, comprised of a large number of distinct plasma proteins, is an effector of both the acquired and innate immune systems. The point of convergence of the ...
    pfam00207
    Location:737 → 825
    A2M; Alpha-2-macroglobulin family
    pfam01835
    Location:88 → 181
    A2M_N; MG2 domain
    pfam07677
    Location:1382 → 1472
    A2M_recep; A-macroglobulin receptor
    pfam07703
    Location:431 → 573
    A2M_N_2; Alpha-2-macroglobulin family N-terminal region
    cl02512
    Location:1491 → 1640
    NTR_like; NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in netrins, complement proteins, tissue inhibitors of metalloproteases (TIMP), and procollagen C-proteinase enhancers (PCOLCE), amongst others. In netrins, the ...

  2. XM_021414083.1 → XP_021269758.1  complement C5 isoform X2

    Related
    ENSNMEP00000012117.1, ENSNMET00000018901.1
    Conserved Domains (7) summary
    cd00017
    Location:689 → 753
    ANATO; Anaphylatoxin homologous domain; C3a, C4a and C5a anaphylatoxins are protein fragments generated enzymatically in serum during activation of complement molecules C3, C4, and C5. They induce smooth muscle contraction. These fragments are homologous to ...
    cd02896
    Location:995 → 1302
    complement_C3_C4_C5; Proteins similar to C3, C4 and C5 of vertebrate complement. The vertebrate complement system, comprised of a large number of distinct plasma proteins, is an effector of both the acquired and innate immune systems. The point of convergence of the ...
    pfam00207
    Location:775 → 863
    A2M; Alpha-2-macroglobulin family
    pfam01835
    Location:126 → 219
    A2M_N; MG2 domain
    pfam07677
    Location:1420 → 1510
    A2M_recep; A-macroglobulin receptor
    pfam07703
    Location:469 → 611
    A2M_N_2; Alpha-2-macroglobulin family N-terminal region
    cl02512
    Location:1529 → 1678
    NTR_like; NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in netrins, complement proteins, tissue inhibitors of metalloproteases (TIMP), and procollagen C-proteinase enhancers (PCOLCE), amongst others. In netrins, the ...
Nucleotide Protein
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