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PREX1 phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1 [ Manis javanica (Malayan pangolin) ]

Gene ID: 108408250, updated on 14-Mar-2024

Summary

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Gene symbol
PREX1
Gene description
phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1
Gene type
protein coding
RefSeq status
MODEL
Organism
Manis javanica
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Pholidota; Manidae; Manis
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: Un
Exon count:
40
Annotation release Status Assembly Chr Location
101 current YNU_ManJav_2.0 (GCF_014570535.1) Unplaced Scaffold NW_023435936.1 (2743657..2922329, complement)
100 previous assembly ManJav1.0 (GCF_001685135.1) Unplaced Scaffold NW_016544627.1 (73492..202831, complement)

NW_023435936.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108408709 Neighboring gene uncharacterized LOC108406678 Neighboring gene uncharacterized LOC108383620 Neighboring gene ADP ribosylation factor guanine nucleotide exchange factor 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Manis javanica Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference YNU_ManJav_2.0 Primary Assembly

Genomic

  1. NW_023435936.1 Reference YNU_ManJav_2.0 Primary Assembly

    Range
    2743657..2922329 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_037006253.1 → XP_036862148.1  phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein

    Conserved Domains (7) summary
    smart00228
    Location:707 → 771
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:625 → 701
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd04440
    Location:504 → 596
    DEP_2_P-Rex; DEP (Dishevelled, Egl-10, and Pleckstrin) domain 2 found in P-Rex-like proteins. The P-Rex family is the guanine-nucleotide exchange factor (GEF) for the small GTPase Rac that contains an N-terminal RhoGEF domain, two DEP and PDZ domains. Rac-GEF ...
    cd01224
    Location:242 → 394
    PH_Collybistin_ASEF; Collybistin/APC-stimulated guanine nucleotide exchange factor pleckstrin homology (PH) domain
    pfam00621
    Location:51 → 236
    RhoGEF; RhoGEF domain
    pfam17820
    Location:728 → 759
    PDZ_6; PDZ domain
    cl02442
    Location:412 → 492
    DEP; DEP domain, named after Dishevelled, Egl-10, and Pleckstrin, where this domain was first discovered. The function of this domain is still not clear, but it is believed to be important for the membrane association of the signaling proteins in which it is ...
Nucleotide Protein
Heading Accession and Version

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