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sptan1 spectrin alpha, non-erythrocytic 1 [ Cyprinodon variegatus (sheepshead minnow) ]

Gene ID: 107093935, updated on 14-Mar-2024

Summary

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Gene symbol
sptan1
Gene description
spectrin alpha, non-erythrocytic 1
Gene type
protein coding
RefSeq status
MODEL
Organism
Cyprinodon variegatus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; Ovalentaria; Atherinomorphae; Cyprinodontiformes; Cyprinodontidae; Cyprinodon
Orthologs
human zebrafish all
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Genomic context

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Location:
chromosome: Un
Exon count:
56
Annotation release Status Assembly Chr Location
100 current C_variegatus-1.0 (GCF_000732505.1) Unplaced Scaffold NW_015150906.1 (399044..450740)

NW_015150906.1Genomic Context describing neighboring genes Neighboring gene suppressor of cancer cell invasion Neighboring gene outer dense fiber of sperm tails 2a Neighboring gene dynein 2 intermediate chain 2 Neighboring gene NAD kinase 2, mitochondrial

Genomic regions, transcripts, and products

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Genomic Sequence:
NW_015150906.1 Unplaced Scaffold Reference C_variegatus-1.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables actin filament binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in actin cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cell junction IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cortical actin cytoskeleton IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
spectrin alpha chain, non-erythrocytic 1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Cyprinodon variegatus Annotation Release 100 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference C_variegatus-1.0 Primary Assembly

Genomic

  1. NW_015150906.1 Reference C_variegatus-1.0 Primary Assembly

    Range
    399044..450740
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_015389284.1 → XP_015244770.1  spectrin alpha chain, non-erythrocytic 1 isoform X1

    Conserved Domains (6) summary
    cd11808
    Location:971 → 1023
    SH3_Alpha_Spectrin; Src homology 3 domain of Alpha Spectrin
    cd00051
    Location:2334 → 2402
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:679 → 890
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00435
    Location:1665 → 1769
    Spectrin; Spectrin repeat
    pfam08726
    Location:2409 → 2477
    EFhand_Ca_insen; Ca2+ insensitive EF hand
    pfam13499
    Location:2337 → 2402
    EF-hand_7; EF-hand domain pair

  2. XM_015389286.1 → XP_015244772.1  spectrin alpha chain, non-erythrocytic 1 isoform X2

    Conserved Domains (6) summary
    cd11808
    Location:971 → 1023
    SH3_Alpha_Spectrin; Src homology 3 domain of Alpha Spectrin
    cd00051
    Location:2329 → 2397
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:679 → 890
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00435
    Location:1660 → 1764
    Spectrin; Spectrin repeat
    pfam08726
    Location:2404 → 2472
    EFhand_Ca_insen; Ca2+ insensitive EF hand
    pfam13499
    Location:2332 → 2397
    EF-hand_7; EF-hand domain pair

  3. XM_015389287.1 → XP_015244773.1  spectrin alpha chain, non-erythrocytic 1 isoform X3

    Conserved Domains (6) summary
    cd11808
    Location:971 → 1023
    SH3_Alpha_Spectrin; Src homology 3 domain of Alpha Spectrin
    cd00051
    Location:2318 → 2386
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:679 → 890
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00435
    Location:1649 → 1753
    Spectrin; Spectrin repeat
    pfam08726
    Location:2393 → 2461
    EFhand_Ca_insen; Ca2+ insensitive EF hand
    pfam13499
    Location:2321 → 2386
    EF-hand_7; EF-hand domain pair

  4. XM_015389288.1 → XP_015244774.1  spectrin alpha chain, non-erythrocytic 1 isoform X4

    Conserved Domains (6) summary
    cd11808
    Location:971 → 1023
    SH3_Alpha_Spectrin; Src homology 3 domain of Alpha Spectrin
    cd00051
    Location:2315 → 2383
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:679 → 890
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00435
    Location:1646 → 1750
    Spectrin; Spectrin repeat
    pfam08726
    Location:2390 → 2458
    EFhand_Ca_insen; Ca2+ insensitive EF hand
    pfam13499
    Location:2318 → 2383
    EF-hand_7; EF-hand domain pair

  5. XM_015389289.1 → XP_015244775.1  spectrin alpha chain, non-erythrocytic 1 isoform X5

    Conserved Domains (6) summary
    cd11808
    Location:971 → 1023
    SH3_Alpha_Spectrin; Src homology 3 domain of Alpha Spectrin
    cd00051
    Location:2310 → 2378
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:679 → 890
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00435
    Location:1641 → 1745
    Spectrin; Spectrin repeat
    pfam08726
    Location:2385 → 2453
    EFhand_Ca_insen; Ca2+ insensitive EF hand
    pfam13499
    Location:2313 → 2378
    EF-hand_7; EF-hand domain pair
Nucleotide Protein
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