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CNPY3 canopy FGF signaling regulator 3 [ Homo sapiens (human) ]

Gene ID: 10695, updated on 8-May-2016
Official Symbol
CNPY3provided by HGNC
Official Full Name
canopy FGF signaling regulator 3provided by HGNC
Primary source
HGNC:HGNC:11968
See related
Ensembl:ENSG00000137161 HPRD:06745; MIM:610774; Vega:OTTHUMG00000014708
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CAG4A; ERDA5; TNRC5; PRAT4A
Summary
This gene encodes a protein that binds members of the toll-like receptor protein family and functions as a chaperone to aid in folding and export of these proteins. Alternative splicing results in multiple transcript variants. Naturally occuring readthrough transcription occurs between this locus and the downstream GNMT (glycine N-methyltransferase) gene and is represented with GeneID:107080644. [provided by RefSeq, Jan 2016]
Orthologs
Location:
6p21.1
Exon count:
8
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 6 NC_000006.12 (42929122..42939270)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (42896860..42911666)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105375063 Neighboring gene pre T-cell antigen receptor alpha Neighboring gene glycine N-methyltransferase Neighboring gene ribosomal protein L24 pseudogene 4 Neighboring gene peroxisomal biogenesis factor 6

  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Innate Immune System, organism-specific biosystem (from REACTOME)
    Innate Immune System, organism-specific biosystemInnate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup
  • Toll-Like Receptors Cascades, organism-specific biosystem (from REACTOME)
    Toll-Like Receptors Cascades, organism-specific biosystemIn human, ten members of the Toll-like receptor (TLR) family (TLR1-TLR10) have been identified (TLR11 has been found in mouse, but not in human). All TLRs have a similar Toll/IL-1 receptor (TIR) doma...
  • Trafficking and processing of endosomal TLR, organism-specific biosystem (from REACTOME)
    Trafficking and processing of endosomal TLR, organism-specific biosystemMammalian TLR3, TLR7, TLR8, TLR9 are endosomal receptors that sense nucleic acids that have been released from endocytosed/phagocytosed bacteria, viruses or parasites. These TLRs have a ligand-recogn...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Readthrough CNPY3-GNMT

Readthrough gene: CNPY3-GNMT, Included gene: GNMT

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
receptor binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
innate immune response IEA
Inferred from Electronic Annotation
more info
 
toll-like receptor signaling pathway TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
endoplasmic reticulum lumen TAS
Traceable Author Statement
more info
 
Preferred Names
protein canopy homolog 3
Names
CAG repeat containing
CTG repeat protein 4a
expanded repeat-domain protein CAG/CTG 5
protein associated with TLR4
protein associated with Toll-like receptor 4A
trinucleotide repeat-containing gene 5 protein

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001318842.1NP_001305771.1  protein canopy homolog 3 isoform 3 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains an alternate exon and uses an alternate splice site in the 5' region, but maintains the reading frame, compared to variant 1. The encoded isoform (3) is longer than isoform (1).
    Source sequence(s)
    AI202110, AK124196, BC011767, BQ063472
    Conserved Domains (1) summary
    pfam11938
    Location:46240
    DUF3456; TLR4 regulator and MIR-interacting MSAP
  2. NM_001318845.1NP_001305774.1  protein canopy homolog 3 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an exon in the 5' coding region and initiates translation at an alternate start codon compared to variant 1. The encoded isoform (2) has a distinct, shorter N-terminus than isoform 1.
    Source sequence(s)
    AI202110, AK124196, BC011767
    Conserved Domains (1) summary
    pfam11938
    Location:2108
    DUF3456; TLR4 regulator and MIR-interacting MSAP
  3. NM_001318847.1NP_001305776.1  protein canopy homolog 3 isoform 5 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) contains an alternate exon in the 5' region, lacks multiple 3' exons, and extends past a splice site used in variant 1, resulting in a distinct 3' coding region and 3' UTR. The encoded isoform (5) has a shorter, distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AK124196, CA431321, CK429647
    Conserved Domains (1) summary
    pfam11938
    Location:4692
    DUF3456; TLR4 regulator and MIR-interacting MSAP
  4. NM_001318848.1NP_001305777.1  protein canopy homolog 3 isoform 6 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) lacks multiple 3' exons and extends past a splice site used in variant 1, resulting in a distinct 3' coding region and 3' UTR. The encoded isoform (6) has a shorter, distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AK124196, BQ680146, CA431321
    Conserved Domains (1) summary
    pfam11938
    Location:46125
    DUF3456; TLR4 regulator and MIR-interacting MSAP
  5. NM_006586.4NP_006577.2  protein canopy homolog 3 isoform 1 precursor

    See identical proteins and their annotated locations for NP_006577.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AI202110, AK124196, BC004423
    Consensus CDS
    CCDS4875.1
    UniProtKB/Swiss-Prot
    Q9BT09
    Related
    ENSP00000361926, OTTHUMP00000016408, ENST00000372836, OTTHUMT00000040564
    Conserved Domains (1) summary
    pfam11938
    Location:46197
    DUF3456; TLR4 regulator and MIR-interacting MSAP

RNA

  1. NR_134880.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) contains an alternate exon in the 5' region compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AI202110, AK124196, BC011767, BG675987
  2. NR_134881.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) has a longer 5' UTR and contains two alternate exons in the 5' region compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AI202110, AK124196, AL035587, BC011767
  3. NR_134882.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) lacks an internal exon and contains an alternate exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AI202110, AK124196, BC011767, BI909527
  4. NR_134885.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10) uses an alternate splice site in the 5' region, lacks multiple 3' exons, and extends past a splice site used in variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK124196, CA431321, CN302713
  5. NR_134886.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (11) lacks an exon in the 5' region, lacks multiple 3' exons, and extends past a splice site used in variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq criteria.
    Source sequence(s)
    AK124196, BF528267, CA431321, CN302712
  6. NR_134888.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an exon in the 5' region and lacks an exon in the 3' region, compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the open reading frame found in variant 1.
    Source sequence(s)
    AI202110, AK124196, BC011767, HY101691

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p2 Primary Assembly

    Range
    42929122..42939270
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005248815.2XP_005248872.1  

    Conserved Domains (1) summary
    pfam11938
    Location:46240
    DUF3456; TLR4 regulator and MIR-interacting MSAP
  2. XM_005248818.1XP_005248875.1  

    Conserved Domains (1) summary
    pfam11938
    Location:172
    DUF3456; TLR4 regulator and MIR-interacting MSAP
  3. XM_005248817.1XP_005248874.1  

    Conserved Domains (1) summary
    pfam11938
    Location:2108
    DUF3456; TLR4 regulator and MIR-interacting MSAP
  4. XM_006714968.1XP_006715031.1  

    See identical proteins and their annotated locations for XP_006715031.1

    Conserved Domains (1) summary
    pfam11938
    Location:172
    DUF3456; TLR4 regulator and MIR-interacting MSAP
  5. XM_011514252.1XP_011512554.1  

    Conserved Domains (1) summary
    pfam11938
    Location:25214
    DUF3456; TLR4 regulator and MIR-interacting MSAP
  6. XM_006714967.2XP_006715030.1  

    Conserved Domains (1) summary
    pfam11938
    Location:37151
    DUF3456; TLR4 regulator and MIR-interacting MSAP

Alternate CHM1_1.1

Genomic

  1. NC_018917.2 Alternate CHM1_1.1

    Range
    42899329..42909477
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)