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TRIO trio Rho guanine nucleotide exchange factor [ Calidris pugnax (ruff) ]

Gene ID: 106887399, updated on 3-Aug-2024

Summary

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Gene symbol
TRIO
Gene description
trio Rho guanine nucleotide exchange factor
See related
Ensembl:ENSCPUG00000015727
Gene type
protein coding
RefSeq status
MODEL
Organism
Calidris pugnax
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Neoaves; Charadriiformes; Scolopacidae; Calidris
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: Un
Exon count:
58
Annotation release Status Assembly Chr Location
100 current ASM143184v1 (GCF_001431845.1) Unplaced Scaffold NW_015090830.1 (4562194..4822072)

NW_015090830.1Genomic Context describing neighboring genes Neighboring gene dynein axonemal heavy chain 5 Neighboring gene uncharacterized LOC106887302 Neighboring gene OTU deubiquitinase with linear linkage specificity like Neighboring gene OTU deubiquitinase with linear linkage specificity

Genomic regions, transcripts, and products

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Genomic Sequence:
NW_015090830.1 Unplaced Scaffold Reference ASM143184v1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
triple functional domain protein

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Calidris pugnax Annotation Release 100 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ASM143184v1

Genomic

  1. NW_015090830.1 Reference ASM143184v1

    Range
    4562194..4822072
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_014940886.1 → XP_014796372.1  triple functional domain protein isoform X3

    Conserved Domains (9) summary
    smart00150
    Location:1133 → 1233
    SPEC; Spectrin repeats
    cd11852
    Location:1649 → 1708
    SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
    smart00516
    Location:59 → 194
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:1960 → 2133
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:557 → 773
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd13240
    Location:1462 → 1584
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
    cd13241
    Location:2138 → 2268
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    pfam00169
    Location:2165 → 2261
    PH; PH domain
    pfam16609
    Location:1705 → 1962
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region

  2. XM_014940885.1 → XP_014796371.1  triple functional domain protein isoform X2

    Conserved Domains (9) summary
    smart00150
    Location:1133 → 1233
    SPEC; Spectrin repeats
    cd11852
    Location:1649 → 1708
    SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
    smart00516
    Location:59 → 194
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:1960 → 2133
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:557 → 773
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd13240
    Location:1462 → 1584
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
    cd13241
    Location:2138 → 2276
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    pfam00169
    Location:2165 → 2261
    PH; PH domain
    pfam16609
    Location:1705 → 1962
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region

  3. XM_014940884.1 → XP_014796370.1  triple functional domain protein isoform X1

    Related
    ENSCPUP00000023168.1, ENSCPUT00000027309.1
    Conserved Domains (14) summary
    smart00150
    Location:1133 → 1233
    SPEC; Spectrin repeats
    cd11852
    Location:1649 → 1708
    SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd11853
    Location:2536 → 2594
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    smart00220
    Location:2777 → 3031
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    smart00516
    Location:59 → 194
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:1960 → 2133
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:557 → 773
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam07679
    Location:2666 → 2757
    I-set; Immunoglobulin I-set domain
    cd13240
    Location:1462 → 1584
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
    cd13241
    Location:2138 → 2276
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    cd14113
    Location:2769 → 3031
    STKc_Trio_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Triple functional domain protein
    pfam00169
    Location:2165 → 2261
    PH; PH domain
    pfam16609
    Location:1705 → 1962
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region
    cl11960
    Location:2683 → 2757
    Ig; Immunoglobulin domain

RNA

  1. XR_001411877.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version

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