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eps8a EGFR pathway substrate 8a, signaling adaptor [ Clupea harengus (Atlantic herring) ]

Gene ID: 105909607, updated on 18-Jun-2024

Summary

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Gene symbol
eps8a
Gene description
EGFR pathway substrate 8a, signaling adaptor
See related
Ensembl:ENSCHAG00020014019
Gene type
protein coding
RefSeq status
MODEL
Organism
Clupea harengus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Clupei; Clupeiformes; Clupeoidei; Clupeidae; Clupea
Also known as
eps8
Orthologs
human zebrafish all
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Genomic context

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See eps8a in Genome Data Viewer
Location:
chromosome: 16
Exon count:
27
Annotation release Status Assembly Chr Location
102 current Ch_v2.0.2 (GCF_900700415.2) 16 NC_045167.1 (23624345..23686185)

Chromosome 16 - NC_045167.1Genomic Context describing neighboring genes Neighboring gene G protein-coupled receptor 19 Neighboring gene TANK-binding kinase 1 Neighboring gene protein tyrosine phosphatase receptor type O Neighboring gene RAS-like, estrogen-regulated, growth inhibitor

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_045167.1 Chromosome 16 Reference Ch_v2.0.2 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables actin binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in Rho protein signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of ruffle assembly IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of Rho protein signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in ruffle membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in vesicle IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
epidermal growth factor receptor kinase substrate 8a
Names
epidermal growth factor receptor pathway substrate 8
epidermal growth factor receptor pathway substrate 8a

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Clupea harengus Annotation Release 102 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Ch_v2.0.2 Primary Assembly

Genomic

  1. NC_045167.1 Reference Ch_v2.0.2 Primary Assembly

    Range
    23624345..23686185
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_031582420.2 → XP_031438280.1  epidermal growth factor receptor kinase substrate 8a isoform X1

    UniProtKB/TrEMBL
    A0A6P8GGL0
    Conserved Domains (3) summary
    cd09540
    Location:751 → 816
    SAM_EPS8-like; SAM domain of EPS8-like subfamily
    cd11764
    Location:537 → 589
    SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
    cd01210
    Location:62 → 192
    PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain

  2. XM_031582422.2 → XP_031438282.1  epidermal growth factor receptor kinase substrate 8a isoform X1

    UniProtKB/TrEMBL
    A0A6P8GGL0
    Conserved Domains (3) summary
    cd09540
    Location:751 → 816
    SAM_EPS8-like; SAM domain of EPS8-like subfamily
    cd11764
    Location:537 → 589
    SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
    cd01210
    Location:62 → 192
    PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain

  3. XM_031582421.2 → XP_031438281.1  epidermal growth factor receptor kinase substrate 8a isoform X1

    UniProtKB/TrEMBL
    A0A6P8GGL0
    Conserved Domains (3) summary
    cd09540
    Location:751 → 816
    SAM_EPS8-like; SAM domain of EPS8-like subfamily
    cd11764
    Location:537 → 589
    SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
    cd01210
    Location:62 → 192
    PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain

  4. XM_031582419.2 → XP_031438279.1  epidermal growth factor receptor kinase substrate 8a isoform X1

    UniProtKB/TrEMBL
    A0A6P8GGL0
    Conserved Domains (3) summary
    cd09540
    Location:751 → 816
    SAM_EPS8-like; SAM domain of EPS8-like subfamily
    cd11764
    Location:537 → 589
    SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
    cd01210
    Location:62 → 192
    PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain

  5. XM_031582423.2 → XP_031438283.1  epidermal growth factor receptor kinase substrate 8a isoform X2

    UniProtKB/TrEMBL
    A0A6P8GGP8
    Conserved Domains (3) summary
    cd09540
    Location:751 → 816
    SAM_EPS8-like; SAM domain of EPS8-like subfamily
    cd11764
    Location:537 → 589
    SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
    cd01210
    Location:62 → 192
    PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain

  6. XM_031582428.2 → XP_031438288.1  epidermal growth factor receptor kinase substrate 8a isoform X6

    UniProtKB/TrEMBL
    A0A6P8GS53
    Conserved Domains (3) summary
    cd09540
    Location:751 → 816
    SAM_EPS8-like; SAM domain of EPS8-like subfamily
    cd11764
    Location:537 → 589
    SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
    cd01210
    Location:62 → 192
    PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain

  7. XM_031582427.2 → XP_031438287.1  epidermal growth factor receptor kinase substrate 8a isoform X6

    UniProtKB/TrEMBL
    A0A6P8GS53
    Conserved Domains (3) summary
    cd09540
    Location:751 → 816
    SAM_EPS8-like; SAM domain of EPS8-like subfamily
    cd11764
    Location:537 → 589
    SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
    cd01210
    Location:62 → 192
    PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain

  8. XM_031582424.2 → XP_031438284.1  epidermal growth factor receptor kinase substrate 8a isoform X3

    UniProtKB/TrEMBL
    A0A6P8GGL6
    Conserved Domains (3) summary
    cd09540
    Location:739 → 804
    SAM_EPS8-like; SAM domain of EPS8-like subfamily
    cd11764
    Location:537 → 589
    SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
    cd01210
    Location:62 → 192
    PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain

  9. XM_031582425.2 → XP_031438285.1  epidermal growth factor receptor kinase substrate 8a isoform X4

    UniProtKB/TrEMBL
    A0A6P8GU22
    Related
    ENSCHAP00020031252.1, ENSCHAT00020033510.1
    Conserved Domains (3) summary
    cd09540
    Location:731 → 796
    SAM_EPS8-like; SAM domain of EPS8-like subfamily
    cd11764
    Location:537 → 589
    SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
    cd01210
    Location:62 → 192
    PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain

  10. XM_031582426.2 → XP_031438286.1  epidermal growth factor receptor kinase substrate 8a isoform X5

    UniProtKB/TrEMBL
    A0A6P8GL33
    Conserved Domains (3) summary
    cd09540
    Location:718 → 783
    SAM_EPS8-like; SAM domain of EPS8-like subfamily
    cd11764
    Location:504 → 556
    SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
    cd01210
    Location:62 → 192
    PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain

  11. XM_031582429.2 → XP_031438289.1  epidermal growth factor receptor kinase substrate 8a isoform X7

    UniProtKB/TrEMBL
    A0A6P8GGL9
    Related
    ENSCHAP00020031181.1, ENSCHAT00020033439.1
    Conserved Domains (3) summary
    cd09540
    Location:692 → 757
    SAM_EPS8-like; SAM domain of EPS8-like subfamily
    cd11764
    Location:478 → 530
    SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
    cd01210
    Location:3 → 133
    PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain
Nucleotide Protein
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