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eps8a epidermal growth factor receptor pathway substrate 8a [ Danio rerio (zebrafish) ]

Gene ID: 393212, updated on 22-Nov-2020

Summary

Official Symbol
eps8aprovided by ZNC
Official Full Name
epidermal growth factor receptor pathway substrate 8aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-871
See related
Ensembl:ENSDARG00000102128
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
ep; eps8; zgc:56041
Orthologs

Genomic context

See eps8a in Genome Data Viewer
Location:
chromosome: 4
Exon count:
27
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 4 NC_007115.7 (151505..178510, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 4 NC_007115.6 (90899..117908)
103 previous assembly Zv9 (GCF_000002035.4) 19 NC_007130.5 (46900125..46927513)

Chromosome 4 - NC_007115.7Genomic Context describing neighboring genes Neighboring gene G protein-coupled receptor 19 Neighboring gene TANK-binding kinase 1 Neighboring gene transfer RNA methionine (anticodon CAU) Neighboring gene protein tyrosine phosphatase receptor type O

Genomic regions, transcripts, and products

Pathways from PubChem

General gene information

Markers

Homology

Clone Names

  • MGC56041

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
actin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
actin binding IEA
Inferred from Electronic Annotation
more info
 
contributes_to guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
signaling adaptor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
Rho protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
actin filament bundle assembly IEA
Inferred from Electronic Annotation
more info
 
barbed-end actin filament capping IEA
Inferred from Electronic Annotation
more info
 
positive regulation of ruffle assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of Rho protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ruffle membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
epidermal growth factor receptor kinase substrate 8; epidermal growth factor receptor kinase substrate 8a
Names
epidermal growth factor receptor pathway substrate 8

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_200242.1NP_956536.1  epidermal growth factor receptor kinase substrate 8a

    See identical proteins and their annotated locations for NP_956536.1

    Status: PROVISIONAL

    Source sequence(s)
    BC047814
    UniProtKB/TrEMBL
    Q7ZUV6
    Conserved Domains (3) summary
    cd09540
    Location:702766
    SAM_EPS8-like; SAM domain of EPS8-like subfamily
    cd11764
    Location:481533
    SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
    cd01210
    Location:48178
    PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007115.7 Reference GRCz11 Primary Assembly

    Range
    151505..178510 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009299923.3XP_009298198.1  epidermal growth factor receptor kinase substrate 8 isoform X13

    See identical proteins and their annotated locations for XP_009298198.1

    Conserved Domains (3) summary
    cd09540
    Location:755819
    SAM_EPS8-like; SAM domain of EPS8-like subfamily
    cd11764
    Location:514566
    SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
    cd01210
    Location:48178
    PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain
  2. XM_021474970.1XP_021330645.1  epidermal growth factor receptor kinase substrate 8 isoform X13

    Conserved Domains (3) summary
    cd09540
    Location:755819
    SAM_EPS8-like; SAM domain of EPS8-like subfamily
    cd11764
    Location:514566
    SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
    cd01210
    Location:48178
    PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain
  3. XM_017354976.2XP_017210465.1  epidermal growth factor receptor kinase substrate 8 isoform X10

  4. XM_017354975.2XP_017210464.1  epidermal growth factor receptor kinase substrate 8 isoform X3

  5. XM_009299921.2XP_009298196.1  epidermal growth factor receptor kinase substrate 8 isoform X11

    UniProtKB/TrEMBL
    A0A286Y8Q3
    Conserved Domains (3) summary
    cd09540
    Location:717781
    SAM_EPS8-like; SAM domain of EPS8-like subfamily
    cd11764
    Location:496548
    SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
    cd01210
    Location:63193
    PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain
  6. XM_009299919.3XP_009298194.1  epidermal growth factor receptor kinase substrate 8 isoform X8

    Conserved Domains (3) summary
    cd09540
    Location:737801
    SAM_EPS8-like; SAM domain of EPS8-like subfamily
    cd11764
    Location:496548
    SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
    cd01210
    Location:63193
    PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain
  7. XM_009299918.3XP_009298193.1  epidermal growth factor receptor kinase substrate 8 isoform X7

    Conserved Domains (3) summary
    cd09540
    Location:749813
    SAM_EPS8-like; SAM domain of EPS8-like subfamily
    cd11764
    Location:529581
    SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
    cd01210
    Location:63193
    PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain
  8. XM_009299917.2XP_009298192.1  epidermal growth factor receptor kinase substrate 8 isoform X6

    Conserved Domains (3) summary
    cd09540
    Location:750814
    SAM_EPS8-like; SAM domain of EPS8-like subfamily
    cd11764
    Location:529581
    SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
    cd01210
    Location:63193
    PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain
  9. XM_009299916.3XP_009298191.1  epidermal growth factor receptor kinase substrate 8 isoform X5

    Conserved Domains (3) summary
    cd09540
    Location:762826
    SAM_EPS8-like; SAM domain of EPS8-like subfamily
    cd11764
    Location:529581
    SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
    cd01210
    Location:63193
    PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain
  10. XM_009299914.3XP_009298189.1  epidermal growth factor receptor kinase substrate 8 isoform X2

    Conserved Domains (3) summary
    cd09540
    Location:769833
    SAM_EPS8-like; SAM domain of EPS8-like subfamily
    cd11764
    Location:529581
    SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
    cd01210
    Location:63193
    PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain
  11. XM_009299915.2XP_009298190.1  epidermal growth factor receptor kinase substrate 8 isoform X4

    Conserved Domains (3) summary
    cd09540
    Location:770834
    SAM_EPS8-like; SAM domain of EPS8-like subfamily
    cd11764
    Location:529581
    SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
    cd01210
    Location:63193
    PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain
  12. XM_009299913.3XP_009298188.1  epidermal growth factor receptor kinase substrate 8 isoform X1

    Conserved Domains (3) summary
    cd09540
    Location:770834
    SAM_EPS8-like; SAM domain of EPS8-like subfamily
    cd11764
    Location:529581
    SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
    cd01210
    Location:63193
    PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain
  13. XM_005168496.3XP_005168553.1  epidermal growth factor receptor kinase substrate 8 isoform X14

    UniProtKB/TrEMBL
    F1QMN2
    Related
    ENSDARP00000133193.2, ENSDART00000171333.2
    Conserved Domains (3) summary
    cd09540
    Location:702766
    SAM_EPS8-like; SAM domain of EPS8-like subfamily
    cd11764
    Location:481533
    SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
    cd01210
    Location:48178
    PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain
  14. XM_009299922.3XP_009298197.1  epidermal growth factor receptor kinase substrate 8 isoform X12

    See identical proteins and their annotated locations for XP_009298197.1

    Conserved Domains (3) summary
    cd09540
    Location:755819
    SAM_EPS8-like; SAM domain of EPS8-like subfamily
    cd11764
    Location:514566
    SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
    cd01210
    Location:48178
    PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain
  15. XM_009299920.3XP_009298195.1  epidermal growth factor receptor kinase substrate 8 isoform X9

    Conserved Domains (3) summary
    cd09540
    Location:770834
    SAM_EPS8-like; SAM domain of EPS8-like subfamily
    cd11764
    Location:529581
    SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
    cd01210
    Location:63193
    PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain
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