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MTR 5-methyltetrahydrofolate-homocysteine methyltransferase [ Cercocebus atys (sooty mangabey) ]

Gene ID: 105574904, updated on 13-Mar-2024

Summary

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Gene symbol
MTR
Gene description
5-methyltetrahydrofolate-homocysteine methyltransferase
See related
Ensembl:ENSCATG00000031365
Gene type
protein coding
RefSeq status
MODEL
Organism
Cercocebus atys
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Cercocebus
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: Un
Exon count:
34
Annotation release Status Assembly Chr Location
100 current Caty_1.0 (GCF_000955945.1) Unplaced Scaffold NW_012003946.1 (8113263..8226355)

NW_012003946.1Genomic Context describing neighboring genes Neighboring gene HEAT repeat containing 1 Neighboring gene actinin alpha 2 Neighboring gene 40S ribosomal protein SA-like Neighboring gene uncharacterized LOC105574906 Neighboring gene uncharacterized LOC105574907

Genomic regions, transcripts, and products

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Genomic Sequence:
NW_012003946.1 Unplaced Scaffold Reference Caty_1.0

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables cobalamin binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables methionine synthase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in methionine biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in pteridine-containing compound metabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
methionine synthase

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Cercocebus atys Annotation Release 100 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Caty_1.0

Genomic

  1. NW_012003946.1 Reference Caty_1.0

    Range
    8113263..8226355
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_012036239.1 → XP_011891629.1  methionine synthase isoform X1

    UniProtKB/TrEMBL
    A0A2K5LQ28, A0A2K5LQ32
    Related
    ENSCATP00000015051.1, ENSCATT00000039200.1
    Conserved Domains (5) summary
    COG0646
    Location:21 → 340
    MetH1; Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]
    PRK09490
    Location:19 → 1261
    metH; B12-dependent methionine synthase; Provisional
    cd00740
    Location:371 → 627
    MeTr; MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent ...
    cd02069
    Location:671 → 897
    methionine_synthase_B12_BD; B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy).
    pfam02965
    Location:965 → 1246
    Met_synt_B12; Vitamin B12 dependent methionine synthase, activation domain

  2. XM_012036242.1 → XP_011891632.1  methionine synthase isoform X4

    UniProtKB/TrEMBL
    A0A2K5LQ28
    Conserved Domains (5) summary
    COG0646
    Location:21 → 340
    MetH1; Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]
    PRK09490
    Location:19 → 1200
    metH; B12-dependent methionine synthase; Provisional
    cd00740
    Location:371 → 627
    MeTr; MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent ...
    cd02069
    Location:671 → 897
    methionine_synthase_B12_BD; B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy).
    pfam02965
    Location:965 → 1200
    Met_synt_B12; Vitamin B12 dependent methionine synthase, activation domain

  3. XM_012036241.1 → XP_011891631.1  methionine synthase isoform X3

    UniProtKB/TrEMBL
    A0A2K5LQ28
    Conserved Domains (5) summary
    COG0646
    Location:21 → 340
    MetH1; Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]
    PRK09490
    Location:19 → 1244
    metH; B12-dependent methionine synthase; Provisional
    cd00740
    Location:371 → 627
    MeTr; MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent ...
    cd02069
    Location:671 → 897
    methionine_synthase_B12_BD; B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy).
    pfam02965
    Location:965 → 1229
    Met_synt_B12; Vitamin B12 dependent methionine synthase, activation domain

  4. XM_012036244.1 → XP_011891634.1  methionine synthase isoform X5

    UniProtKB/TrEMBL
    A0A2K5LQ28
    Conserved Domains (4) summary
    COG0646
    Location:21 → 340
    MetH1; Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]
    cd00740
    Location:371 → 627
    MeTr; MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent ...
    cd02069
    Location:671 → 897
    methionine_synthase_B12_BD; B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy).
    pfam02965
    Location:965 → 1068
    Met_synt_B12; Vitamin B12 dependent methionine synthase, activation domain

  5. XM_012036240.1 → XP_011891630.1  methionine synthase isoform X2

    UniProtKB/TrEMBL
    A0A2K5LQ28
    Conserved Domains (5) summary
    COG0646
    Location:20 → 339
    MetH1; Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]
    PRK09490
    Location:18 → 1260
    metH; B12-dependent methionine synthase; Provisional
    cd00740
    Location:370 → 626
    MeTr; MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent ...
    cd02069
    Location:670 → 896
    methionine_synthase_B12_BD; B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy).
    pfam02965
    Location:964 → 1245
    Met_synt_B12; Vitamin B12 dependent methionine synthase, activation domain

  6. XM_012036246.1 → XP_011891636.1  methionine synthase isoform X7

    UniProtKB/TrEMBL
    A0A2K5LQ83
    Related
    ENSCATP00000015100.1, ENSCATT00000039250.1
    Conserved Domains (4) summary
    COG1410
    Location:2 → 823
    MetH2; Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]
    cd00740
    Location:1 → 220
    MeTr; MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent ...
    cd02069
    Location:264 → 490
    methionine_synthase_B12_BD; B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy).
    pfam02965
    Location:558 → 839
    Met_synt_B12; Vitamin B12 dependent methionine synthase, activation domain

  7. XM_012036245.1 → XP_011891635.1  methionine synthase isoform X6

    Conserved Domains (5) summary
    COG1410
    Location:39 → 927
    MetH2; Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]
    cd00740
    Location:68 → 324
    MeTr; MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent ...
    cd02069
    Location:368 → 594
    methionine_synthase_B12_BD; B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy).
    pfam02965
    Location:662 → 943
    Met_synt_B12; Vitamin B12 dependent methionine synthase, activation domain
    cl22882
    Location:1 → 37
    S-methyl_trans; Homocysteine S-methyltransferase

RNA

  1. XR_001011021.1 RNA Sequence

  2. XR_001011020.1 RNA Sequence

Nucleotide Protein
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