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Mtr 5-methyltetrahydrofolate-homocysteine methyltransferase [ Mus musculus (house mouse) ]

Gene ID: 238505, updated on 9-May-2024

Summary

Official Symbol
Mtrprovided by MGI
Official Full Name
5-methyltetrahydrofolate-homocysteine methyltransferaseprovided by MGI
Primary source
MGI:MGI:894292
See related
Ensembl:ENSMUSG00000021311 AllianceGenome:MGI:894292
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MS; D830038K18Rik
Summary
Enables methionine synthase activity. Acts upstream of or within methionine biosynthetic process. Predicted to be located in cytoplasm. Predicted to be active in cytosol. Is expressed in several structures, including eye; genitourinary system; integumental system; limb; and nervous system. Human ortholog(s) of this gene implicated in several diseases, including IgA glomerulonephritis; autistic disorder; hematologic cancer (multiple); hyperhomocysteinemia; and methylmalonic aciduria and homocystinuria type cblG. Orthologous to human MTR (5-methyltetrahydrofolate-homocysteine methyltransferase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in heart adult (RPKM 14.2), limb E14.5 (RPKM 5.2) and 22 other tissues See more
Orthologs
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Genomic context

See Mtr in Genome Data Viewer
Location:
13 A1; 13 4.52 cM
Exon count:
33
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (12196217..12273090, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (12181331..12258199, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene ryanodine receptor 2, cardiac Neighboring gene STARR-seq mESC enhancer starr_33653 Neighboring gene STARR-seq mESC enhancer starr_33654 Neighboring gene STARR-seq mESC enhancer starr_33656 Neighboring gene STARR-seq mESC enhancer starr_33658 Neighboring gene STARR-seq mESC enhancer starr_33659 Neighboring gene STARR-seq mESC enhancer starr_33660 Neighboring gene STARR-seq mESC enhancer starr_33661 Neighboring gene STARR-seq mESC enhancer starr_33662 Neighboring gene STARR-positive B cell enhancer mm9_chr13:12302569-12302869 Neighboring gene ribosomal protein S7 pseudogene Neighboring gene predicted gene 10336 Neighboring gene STARR-positive B cell enhancer ABC_E7201 Neighboring gene STARR-seq mESC enhancer starr_33665 Neighboring gene STARR-seq mESC enhancer starr_33666 Neighboring gene actinin alpha 2 Neighboring gene predicted gene, 40667 Neighboring gene predicted gene 5445

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (1)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables amino acid binding ISO
Inferred from Sequence Orthology
more info
 
enables cobalamin binding IEA
Inferred from Electronic Annotation
more info
 
enables folic acid binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables methionine synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables methionine synthase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables methionine synthase activity ISO
Inferred from Sequence Orthology
more info
 
enables methyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within amino acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in axon regeneration ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to nitric oxide ISO
Inferred from Sequence Orthology
more info
 
involved_in cobalamin metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cobalamin metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in homocysteine metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in homocysteine metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in methionine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within methionine biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in methionine biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in methionine metabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within methylation IEA
Inferred from Electronic Annotation
more info
 
involved_in pteridine-containing compound metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in response to axon injury ISO
Inferred from Sequence Orthology
more info
 
involved_in tetrahydrofolate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in tetrahydrofolate metabolic process ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
methionine synthase
Names
cobalamin-dependent methionine synthase
vitamin-B12 dependent methionine synthase
NP_001074597.1
XP_006516724.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081128.3NP_001074597.1  methionine synthase

    See identical proteins and their annotated locations for NP_001074597.1

    Status: VALIDATED

    Source sequence(s)
    AI894170, BB630813, BC145683
    Consensus CDS
    CCDS36591.1
    UniProtKB/Swiss-Prot
    A6H5Y3, Q3UQP2
    Related
    ENSMUSP00000097442.5, ENSMUST00000099856.6
    Conserved Domains (1) summary
    PRK09490
    Location:11249
    metH; B12-dependent methionine synthase; Provisional

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    12196217..12273090 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006516661.4XP_006516724.1  methionine synthase isoform X1

    Conserved Domains (1) summary
    PRK09490
    Location:1995
    metH; B12-dependent methionine synthase; Provisional

RNA

  1. XR_003950449.2 RNA Sequence