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INSR insulin receptor [ Colobus angolensis palliatus ]

Gene ID: 105512899, updated on 11-Apr-2024

Summary

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Gene symbol
INSR
Gene description
insulin receptor
See related
Ensembl:ENSCANG00000041029
Gene type
protein coding
RefSeq status
MODEL
Organism
Colobus angolensis palliatus (sub-species: palliatus)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Colobinae; Colobus
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: Un
Exon count:
21
Annotation release Status Assembly Chr Location
100 current Cang.pa_1.0 (GCF_000951035.1) Unplaced Scaffold NW_012115377.1 (4542608..4712236, complement)

NW_012115377.1Genomic Context describing neighboring genes Neighboring gene putative EGF-like module-containing mucin-like hormone receptor-like 4 Neighboring gene zinc finger protein 557 Neighboring gene uncharacterized LOC105512898 Neighboring gene Rho/Rac guanine nucleotide exchange factor 18 Neighboring gene peroxisomal biogenesis factor 11 gamma

Genomic regions, transcripts, and products

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Genomic Sequence:
NW_012115377.1 Unplaced Scaffold Reference Cang.pa_1.0

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables insulin receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables insulin receptor substrate binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables phosphatidylinositol 3-kinase binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell surface receptor protein tyrosine kinase signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in glucose homeostasis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in multicellular organism development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of MAPK cascade IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein autophosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in axon IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of insulin receptor complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
insulin receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Colobus angolensis palliatus Annotation Release 100 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Cang.pa_1.0

Genomic

  1. NW_012115377.1 Reference Cang.pa_1.0

    Range
    4542608..4712236 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011943557.1 → XP_011798947.1  insulin receptor isoform X3

    UniProtKB/TrEMBL
    A0A2K5K0Z5
    Conserved Domains (6) summary
    cd05061
    Location:1009 → 1296
    PTKc_InsR; Catalytic domain of the Protein Tyrosine Kinase, Insulin Receptor
    cd00063
    Location:861 → 938
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00064
    Location:240 → 287
    FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
    pfam00757
    Location:185 → 343
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:365 → 478
    Recep_L_domain; Receptor L domain
    pfam07714
    Location:1016 → 1283
    Pkinase_Tyr; Protein tyrosine kinase

  2. XM_011943556.1 → XP_011798946.1  insulin receptor isoform X2

    UniProtKB/TrEMBL
    A0A2K5K0V8, A0A2K5K0Z5
    Related
    ENSCANP00000034728.1, ENSCANT00000057962.1
    Conserved Domains (6) summary
    cd05061
    Location:1010 → 1297
    PTKc_InsR; Catalytic domain of the Protein Tyrosine Kinase, Insulin Receptor
    cd00063
    Location:861 → 938
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00064
    Location:240 → 287
    FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
    pfam00757
    Location:185 → 343
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:365 → 478
    Recep_L_domain; Receptor L domain
    pfam07714
    Location:1017 → 1284
    Pkinase_Tyr; Protein tyrosine kinase

  3. XM_011943555.1 → XP_011798945.1  insulin receptor isoform X1

    UniProtKB/TrEMBL
    A0A2K5K0T8, A0A2K5K0Z5
    Related
    ENSCANP00000034724.1, ENSCANT00000057958.1
    Conserved Domains (6) summary
    cd05061
    Location:1022 → 1309
    PTKc_InsR; Catalytic domain of the Protein Tyrosine Kinase, Insulin Receptor
    cd00063
    Location:873 → 950
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00064
    Location:240 → 287
    FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
    pfam00757
    Location:185 → 343
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:365 → 478
    Recep_L_domain; Receptor L domain
    pfam07714
    Location:1029 → 1296
    Pkinase_Tyr; Protein tyrosine kinase
Nucleotide Protein
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