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CBLB Cbl proto-oncogene B [ Rhinopithecus roxellana (golden snub-nosed monkey) ]

Gene ID: 104674409, updated on 12-Mar-2024

Summary

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Gene symbol
CBLB
Gene description
Cbl proto-oncogene B
See related
Ensembl:ENSRROG00000043707
Gene type
protein coding
RefSeq status
MODEL
Organism
Rhinopithecus roxellana
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Colobinae; Rhinopithecus
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 1
Exon count:
21
Annotation release Status Assembly Chr Location
101 current ASM756505v1 (GCF_007565055.1) 1 NC_044549.1 (26322232..26540987, complement)
100 previous assembly Rrox_v1 (GCF_000769185.1) Unplaced Scaffold NW_010822348.1 (851525..1069898)

Chromosome 1 - NC_044549.1Genomic Context describing neighboring genes Neighboring gene ezrin pseudogene Neighboring gene activated leukocyte cell adhesion molecule Neighboring gene uncharacterized LOC115900361 Neighboring gene uncharacterized LOC115899563 Neighboring gene rRNA-processing protein FCF1 homolog pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables SH3 domain binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables phosphotyrosine residue binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables receptor tyrosine kinase binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables ubiquitin protein ligase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell surface receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of epidermal growth factor-activated receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane raft IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
E3 ubiquitin-protein ligase CBL-B

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Rhinopithecus roxellana Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ASM756505v1 Primary Assembly

Genomic

  1. NC_044549.1 Reference ASM756505v1 Primary Assembly

    Range
    26322232..26540987 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030940505.1 → XP_030796365.1  E3 ubiquitin-protein ligase CBL-B isoform X1

    UniProtKB/TrEMBL
    A0A2K6RJ27
    Conserved Domains (5) summary
    cd09920
    Location:248 → 344
    SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
    cd14392
    Location:931 → 971
    UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
    cd16709
    Location:354 → 419
    RING-HC_Cbl-b; RING finger, HC subclass, found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
    pfam02262
    Location:44 → 164
    Cbl_N; CBL proto-oncogene N-terminal domain 1
    pfam02761
    Location:171 → 254
    Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain

  2. XM_030940511.1 → XP_030796371.1  E3 ubiquitin-protein ligase CBL-B isoform X1

    UniProtKB/TrEMBL
    A0A2K6RJ27
    Conserved Domains (5) summary
    cd09920
    Location:248 → 344
    SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
    cd14392
    Location:931 → 971
    UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
    cd16709
    Location:354 → 419
    RING-HC_Cbl-b; RING finger, HC subclass, found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
    pfam02262
    Location:44 → 164
    Cbl_N; CBL proto-oncogene N-terminal domain 1
    pfam02761
    Location:171 → 254
    Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain

  3. XM_030940517.1 → XP_030796377.1  E3 ubiquitin-protein ligase CBL-B isoform X1

    UniProtKB/TrEMBL
    A0A2K6RJ27
    Conserved Domains (5) summary
    cd09920
    Location:248 → 344
    SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
    cd14392
    Location:931 → 971
    UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
    cd16709
    Location:354 → 419
    RING-HC_Cbl-b; RING finger, HC subclass, found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
    pfam02262
    Location:44 → 164
    Cbl_N; CBL proto-oncogene N-terminal domain 1
    pfam02761
    Location:171 → 254
    Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain

  4. XM_010378710.2 → XP_010377012.1  E3 ubiquitin-protein ligase CBL-B isoform X2

    See identical proteins and their annotated locations for XP_010377012.1

    UniProtKB/TrEMBL
    A0A2K6RJ34
    Related
    ENSRROP00000041020.1
    Conserved Domains (5) summary
    cd09920
    Location:248 → 344
    SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
    cd14392
    Location:887 → 927
    UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
    cd16709
    Location:354 → 419
    RING-HC_Cbl-b; RING finger, HC subclass, found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
    pfam02262
    Location:44 → 164
    Cbl_N; CBL proto-oncogene N-terminal domain 1
    pfam02761
    Location:171 → 254
    Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain

  5. XM_010378709.2 → XP_010377011.1  E3 ubiquitin-protein ligase CBL-B isoform X1

    See identical proteins and their annotated locations for XP_010377011.1

    UniProtKB/TrEMBL
    A0A2K6RJ27
    Related
    ENSRROP00000041010.1
    Conserved Domains (5) summary
    cd09920
    Location:248 → 344
    SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
    cd14392
    Location:931 → 971
    UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
    cd16709
    Location:354 → 419
    RING-HC_Cbl-b; RING finger, HC subclass, found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
    pfam02262
    Location:44 → 164
    Cbl_N; CBL proto-oncogene N-terminal domain 1
    pfam02761
    Location:171 → 254
    Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain

  6. XM_030940519.1 → XP_030796379.1  E3 ubiquitin-protein ligase CBL-B isoform X2

    UniProtKB/TrEMBL
    A0A2K6RJ34
    Conserved Domains (5) summary
    cd09920
    Location:248 → 344
    SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
    cd14392
    Location:887 → 927
    UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
    cd16709
    Location:354 → 419
    RING-HC_Cbl-b; RING finger, HC subclass, found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
    pfam02262
    Location:44 → 164
    Cbl_N; CBL proto-oncogene N-terminal domain 1
    pfam02761
    Location:171 → 254
    Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain
Nucleotide Protein
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