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LRRK2 leucine rich repeat kinase 2 [ Chlorocebus sabaeus (green monkey) ]

Gene ID: 103238159, updated on 11-Mar-2024

Summary

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Gene symbol
LRRK2
Gene description
leucine rich repeat kinase 2
See related
Ensembl:ENSCSAG00000007254
Gene type
protein coding
RefSeq status
MODEL
Organism
Chlorocebus sabaeus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Chlorocebus
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: Un
Exon count:
52
Annotation release Status Assembly Chr Location
102 current Vero_WHO_p1.0 (GCF_015252025.1) Unplaced Scaffold NW_023666037.1 (210139337..210285872, complement)
100 previous assembly Chlorocebus_sabeus 1.1 (GCF_000409795.2) 11 NC_023652.1 (36490775..36634215)

NW_023666037.1Genomic Context describing neighboring genes Neighboring gene contactin 1 Neighboring gene methionine aminopeptidase 1-like Neighboring gene U6 spliceosomal RNA Neighboring gene mucin 19, oligomeric Neighboring gene 60S ribosomal protein L30-like Neighboring gene solute carrier family 2 member 13 Neighboring gene snurportin-1-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables GTP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
leucine-rich repeat serine/threonine-protein kinase 2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Chlorocebus sabaeus Annotation Release 102 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Vero_WHO_p1.0

Genomic

  1. NW_023666037.1 Reference Vero_WHO_p1.0

    Range
    210139337..210285872 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_037997280.1 → XP_037853208.1  leucine-rich repeat serine/threonine-protein kinase 2 isoform X1

    UniProtKB/TrEMBL
    A0A0D9R4H9
    Conserved Domains (6) summary
    PRK15370
    Location:982 → 1200
    PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP
    cd09914
    Location:1334 → 1507
    RocCOR; Ras of complex proteins (Roc) C-terminal of Roc (COR) domain family
    COG4886
    Location:1108 → 1360
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    cd14068
    Location:1884 → 2135
    STKc_LRRK2; Catalytic domain of the Serine/Threonine Kinase, Leucine-Rich Repeat Kinase 2
    sd00033
    Location:1013 → 1036
    LRR_RI; leucine-rich repeat [structural motif]
    pfam16095
    Location:1527 → 1740
    COR; C-terminal of Roc, COR, domain

  2. XM_008002889.2 → XP_008001080.2  leucine-rich repeat serine/threonine-protein kinase 2 isoform X4

    UniProtKB/TrEMBL
    A0A0D9R4H9
    Conserved Domains (6) summary
    PRK15370
    Location:492 → 710
    PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP
    cd09914
    Location:844 → 1017
    RocCOR; Ras of complex proteins (Roc) C-terminal of Roc (COR) domain family
    COG4886
    Location:618 → 870
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    cd14068
    Location:1394 → 1645
    STKc_LRRK2; Catalytic domain of the Serine/Threonine Kinase, Leucine-Rich Repeat Kinase 2
    sd00033
    Location:523 → 546
    LRR_RI; leucine-rich repeat [structural motif]
    pfam16095
    Location:1037 → 1250
    COR; C-terminal of Roc, COR, domain

  3. XM_008002887.2 → XP_008001078.2  leucine-rich repeat serine/threonine-protein kinase 2 isoform X2

    UniProtKB/TrEMBL
    A0A0D9R4H9
    Conserved Domains (5) summary
    cd09914
    Location:1334 → 1507
    RocCOR; Ras of complex proteins (Roc) C-terminal of Roc (COR) domain family
    PLN00113
    Location:986 → 1285
    PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
    sd00033
    Location:1013 → 1036
    LRR_RI; leucine-rich repeat [structural motif]
    pfam16095
    Location:1527 → 1740
    COR; C-terminal of Roc, COR, domain
    cl21453
    Location:1884 → 2093
    PKc_like; Protein Kinases, catalytic domain

  4. XM_008002888.2 → XP_008001079.2  leucine-rich repeat serine/threonine-protein kinase 2 isoform X3

    UniProtKB/TrEMBL
    A0A0D9R4H9
    Conserved Domains (5) summary
    cd09914
    Location:1334 → 1507
    RocCOR; Ras of complex proteins (Roc) C-terminal of Roc (COR) domain family
    PLN00113
    Location:986 → 1285
    PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
    sd00033
    Location:1013 → 1036
    LRR_RI; leucine-rich repeat [structural motif]
    pfam16095
    Location:1527 → 1740
    COR; C-terminal of Roc, COR, domain
    cl21453
    Location:1884 → 2036
    PKc_like; Protein Kinases, catalytic domain
Nucleotide Protein
Heading Accession and Version

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