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Lrrk2 leucine-rich repeat kinase 2 [ Mus musculus (house mouse) ]

Gene ID: 66725, updated on 7-Aug-2018

Summary

Official Symbol
Lrrk2provided by MGI
Official Full Name
leucine-rich repeat kinase 2provided by MGI
Primary source
MGI:MGI:1913975
See related
Ensembl:ENSMUSG00000036273 Vega:OTTMUSG00000020864
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm927; cI-46; AW561911; 4921513O20Rik; 9330188B09Rik; D630001M17Rik
Expression
Broad expression in kidney adult (RPKM 2.7), lung adult (RPKM 2.3) and 24 other tissues See more
Orthologs

Genomic context

See Lrrk2 in Genome Data Viewer
Location:
15; 15 E3
Exon count:
51
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 15 NC_000081.6 (91672809..91816124)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 15 NC_000081.5 (91503655..91646555)

Chromosome 15 - NC_000081.6Genomic Context describing neighboring genes Neighboring gene solute carrier family 2 (facilitated glucose transporter), member 13 Neighboring gene olfactomedin-like 2A pseudogene Neighboring gene tripartite motif-containing 59 pseudogene Neighboring gene RAS related protein 1b pseudogene Neighboring gene mucin 19 Neighboring gene submandibular gland protein C

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
GTP binding ISO
Inferred from Sequence Orthology
more info
PubMed 
GTP-dependent protein kinase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
GTPase activator activity ISO
Inferred from Sequence Orthology
more info
 
GTPase activity ISO
Inferred from Sequence Orthology
more info
 
MAP kinase kinase activity ISO
Inferred from Sequence Orthology
more info
 
Rho GTPase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Rho GTPase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Rho GTPase binding ISO
Inferred from Sequence Orthology
more info
 
SNARE binding ISO
Inferred from Sequence Orthology
more info
 
actin binding ISO
Inferred from Sequence Orthology
more info
 
beta-catenin destruction complex binding IPI
Inferred from Physical Interaction
more info
PubMed 
clathrin binding ISO
Inferred from Sequence Orthology
more info
 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
identical protein binding ISO
Inferred from Sequence Orthology
more info
 
ion channel binding ISO
Inferred from Sequence Orthology
more info
 
kinase activity ISO
Inferred from Sequence Orthology
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
peroxidase inhibitor activity ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
protein kinase A binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase A binding ISO
Inferred from Sequence Orthology
more info
 
protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein serine/threonine kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
protein-containing complex binding IC
Inferred by Curator
more info
PubMed 
receptor signaling complex scaffold activity IC
Inferred by Curator
more info
PubMed 
syntaxin-1 binding ISO
Inferred from Sequence Orthology
more info
 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
tubulin binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
GTP metabolic process ISO
Inferred from Sequence Orthology
more info
 
Golgi organization IGI
Inferred from Genetic Interaction
more info
PubMed 
Golgi organization ISO
Inferred from Sequence Orthology
more info
 
MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
Wnt signalosome assembly IC
Inferred by Curator
more info
PubMed 
Wnt signalosome assembly ISO
Inferred from Sequence Orthology
more info
 
activation of MAPK activity ISO
Inferred from Sequence Orthology
more info
 
activation of MAPKK activity ISO
Inferred from Sequence Orthology
more info
 
autophagy IEA
Inferred from Electronic Annotation
more info
 
calcium-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
calcium-mediated signaling ISO
Inferred from Sequence Orthology
more info
 
cell differentiation IEA
Inferred from Electronic Annotation
more info
 
cellular protein localization IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to dopamine ISO
Inferred from Sequence Orthology
more info
 
cellular response to manganese ion ISO
Inferred from Sequence Orthology
more info
 
cellular response to oxidative stress ISO
Inferred from Sequence Orthology
more info
 
cellular response to starvation ISO
Inferred from Sequence Orthology
more info
 
determination of adult lifespan ISO
Inferred from Sequence Orthology
more info
 
endocytosis ISO
Inferred from Sequence Orthology
more info
 
excitatory postsynaptic potential IMP
Inferred from Mutant Phenotype
more info
PubMed 
exploration behavior ISO
Inferred from Sequence Orthology
more info
 
intracellular distribution of mitochondria ISO
Inferred from Sequence Orthology
more info
 
intracellular signal transduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
locomotory exploration behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
lysosome organization ISO
Inferred from Sequence Orthology
more info
 
mitochondrion localization ISO
Inferred from Sequence Orthology
more info
 
mitochondrion organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrion organization ISO
Inferred from Sequence Orthology
more info
 
negative regulation of GTPase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
negative regulation of autophagosome assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of autophagosome assembly ISO
Inferred from Sequence Orthology
more info
 
negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
negative regulation of excitatory postsynaptic potential IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of hydrogen peroxide-induced cell death ISO
Inferred from Sequence Orthology
more info
 
negative regulation of macroautophagy ISO
Inferred from Sequence Orthology
more info
 
negative regulation of neuron death ISO
Inferred from Sequence Orthology
more info
 
negative regulation of neuron projection development ISO
Inferred from Sequence Orthology
more info
 
negative regulation of protein binding ISO
Inferred from Sequence Orthology
more info
 
negative regulation of protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of protein processing ISO
Inferred from Sequence Orthology
more info
 
negative regulation of protein targeting to mitochondrion ISO
Inferred from Sequence Orthology
more info
 
negative regulation of thioredoxin peroxidase activity by peptidyl-threonine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
neuromuscular junction development ISO
Inferred from Sequence Orthology
more info
 
neuron death ISO
Inferred from Sequence Orthology
more info
 
neuron projection arborization ISO
Inferred from Sequence Orthology
more info
 
neuron projection morphogenesis ISO
Inferred from Sequence Orthology
more info
 
olfactory bulb development ISO
Inferred from Sequence Orthology
more info
 
peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
peptidyl-threonine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
phosphorylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of autophagy IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of autophagy ISO
Inferred from Sequence Orthology
more info
 
positive regulation of canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
 
positive regulation of dopamine receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
positive regulation of histone deacetylase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of microglial cell activation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of nitric-oxide synthase biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of programmed cell death ISO
Inferred from Sequence Orthology
more info
 
positive regulation of proteasomal ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of protein autoubiquitination ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein binding ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein import into nucleus, translocation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of protein import into nucleus, translocation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein ubiquitination ISO
Inferred from Sequence Orthology
more info
 
positive regulation of synaptic vesicle endocytosis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of tumor necrosis factor secretion ISO
Inferred from Sequence Orthology
more info
 
protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
PubMed 
protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein phosphorylation ISO
Inferred from Sequence Orthology
more info
PubMed 
reactive oxygen species metabolic process ISO
Inferred from Sequence Orthology
more info
 
regulation of CAMKK-AMPK signaling cascade ISO
Inferred from Sequence Orthology
more info
 
regulation of autophagy ISO
Inferred from Sequence Orthology
more info
 
regulation of branching morphogenesis of a nerve ISO
Inferred from Sequence Orthology
more info
 
regulation of canonical Wnt signaling pathway IPI
Inferred from Physical Interaction
more info
PubMed 
regulation of dendritic spine morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of dendritic spine morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of dendritic spine morphogenesis ISO
Inferred from Sequence Orthology
more info
 
regulation of dopamine receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of kidney size IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of locomotion ISO
Inferred from Sequence Orthology
more info
 
regulation of lysosomal lumen pH ISO
Inferred from Sequence Orthology
more info
 
regulation of membrane potential ISO
Inferred from Sequence Orthology
more info
 
regulation of mitochondrial depolarization ISO
Inferred from Sequence Orthology
more info
 
regulation of neuroblast proliferation ISO
Inferred from Sequence Orthology
more info
 
regulation of neuron death ISO
Inferred from Sequence Orthology
more info
 
regulation of neuron maturation ISO
Inferred from Sequence Orthology
more info
 
regulation of protein kinase A signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of retrograde transport, endosome to Golgi IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of retrograde transport, endosome to Golgi ISO
Inferred from Sequence Orthology
more info
 
regulation of synaptic transmission, glutamatergic IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of synaptic vesicle exocytosis ISO
Inferred from Sequence Orthology
more info
 
regulation of synaptic vesicle transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of synaptic vesicle transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to oxidative stress ISO
Inferred from Sequence Orthology
more info
 
synaptic vesicle recycling TAS
Traceable Author Statement
more info
PubMed 
tangential migration from the subventricular zone to the olfactory bulb ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
Golgi-associated vesicle ISO
Inferred from Sequence Orthology
more info
 
Wnt signalosome IDA
Inferred from Direct Assay
more info
PubMed 
Wnt signalosome ISO
Inferred from Sequence Orthology
more info
 
amphisome ISO
Inferred from Sequence Orthology
more info
 
autolysosome ISO
Inferred from Sequence Orthology
more info
 
axon ISO
Inferred from Sequence Orthology
more info
 
caveola neck ISO
Inferred from Sequence Orthology
more info
 
cell junction IEA
Inferred from Electronic Annotation
more info
 
cell projection IEA
Inferred from Electronic Annotation
more info
 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytoplasmic side of mitochondrial outer membrane ISO
Inferred from Sequence Orthology
more info
 
cytoplasmic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol ISO
Inferred from Sequence Orthology
more info
PubMed 
dendrite IDA
Inferred from Direct Assay
more info
PubMed 
dendrite ISO
Inferred from Sequence Orthology
more info
 
dendrite cytoplasm ISO
Inferred from Sequence Orthology
more info
 
endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
endosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endosome IDA
Inferred from Direct Assay
more info
PubMed 
growth cone ISO
Inferred from Sequence Orthology
more info
 
inclusion body ISO
Inferred from Sequence Orthology
more info
 
intracellular ISO
Inferred from Sequence Orthology
more info
 
intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
lysosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
lysosome IDA
Inferred from Direct Assay
more info
PubMed 
membrane ISO
Inferred from Sequence Orthology
more info
 
membrane raft IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
membrane raft IDA
Inferred from Direct Assay
more info
PubMed 
microvillus ISO
Inferred from Sequence Orthology
more info
 
mitochondrial inner membrane IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrial matrix IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrial membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrial membrane ISO
Inferred from Sequence Orthology
more info
 
mitochondrial outer membrane IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion ISO
Inferred from Sequence Orthology
more info
 
multivesicular body, internal vesicle ISO
Inferred from Sequence Orthology
more info
 
neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neuron projection ISO
Inferred from Sequence Orthology
more info
 
neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
nucleus ISO
Inferred from Sequence Orthology
more info
 
perikaryon ISO
Inferred from Sequence Orthology
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
ribonucleoprotein complex IDA
Inferred from Direct Assay
more info
PubMed 
synapse IDA
Inferred from Direct Assay
more info
PubMed 
synapse ISO
Inferred from Sequence Orthology
more info
 
synaptic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
terminal bouton IC
Inferred by Curator
more info
PubMed 
trans-Golgi network IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
leucine-rich repeat serine/threonine-protein kinase 2
NP_080006.3
XP_006521340.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_025730.3NP_080006.3  leucine-rich repeat serine/threonine-protein kinase 2

    See identical proteins and their annotated locations for NP_080006.3

    Status: VALIDATED

    Source sequence(s)
    AC099704, AC158752, AK014886, AK014938, AK034413, AK050702, AK052591, BF660966
    Consensus CDS
    CCDS37180.1
    UniProtKB/Swiss-Prot
    Q5S006
    UniProtKB/TrEMBL
    Q9CQG8
    Related
    ENSMUSP00000052584.6, OTTMUSP00000022827, ENSMUST00000060642.6, OTTMUST00000049323
    Conserved Domains (6) summary
    cd09914
    Location:13341507
    RocCOR; Ras of complex proteins (Roc) C-terminal of Roc (COR) domain family
    smart00220
    Location:18842128
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    COG1100
    Location:13331551
    Gem1; GTPase SAR1 family domain [General function prediction only]
    cd14068
    Location:18842135
    STKc_LRRK2; Catalytic domain of the Serine/Threonine Kinase, Leucine-Rich Repeat Kinase 2
    sd00033
    Location:10131036
    LRR_RI; leucine-rich repeat [structural motif]
    pfam16095
    Location:15271740
    COR; C-terminal of Roc, COR, domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000081.6 Reference GRCm38.p4 C57BL/6J

    Range
    91672809..91816124
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006521277.3XP_006521340.1  leucine-rich repeat serine/threonine-protein kinase 2 isoform X1

    Conserved Domains (7) summary
    cd09914
    Location:13341507
    RocCOR; Ras of complex proteins (Roc) C-terminal of Roc (COR) domain family
    COG1100
    Location:13331551
    Gem1; GTPase SAR1 family domain [General function prediction only]
    cd00116
    Location:9861240
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:10131036
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:11291208
    LRR_8; Leucine rich repeat
    pfam16095
    Location:15271740
    COR; C-terminal of Roc, COR, domain
    cl21453
    Location:18842036
    PKc_like; Protein Kinases, catalytic domain

RNA

  1. XR_001781561.1 RNA Sequence

  2. XR_875310.2 RNA Sequence

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