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RYR2 ryanodine receptor 2 [ Orycteropus afer afer ]

Gene ID: 103198550, updated on 11-Mar-2024

Summary

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Gene symbol
RYR2
Gene description
ryanodine receptor 2
Gene type
protein coding
RefSeq status
MODEL
Organism
Orycteropus afer afer (sub-species: afer)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Afrotheria; Tubulidentata; Orycteropodidae; Orycteropus
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: Un
Exon count:
106
Annotation release Status Assembly Chr Location
101 current OryAfe1.0 (GCF_000298275.1) Unplaced Scaffold NW_006921683.1 (418098..1518076)

NW_006921683.1Genomic Context describing neighboring genes Neighboring gene zinc finger CCCH domain-containing protein 14-like Neighboring gene diamine acetyltransferase 1-like Neighboring gene zona pellucida glycoprotein 4 Neighboring gene pre-mRNA-splicing regulator WTAP-like

Genomic regions, transcripts, and products

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Genomic Sequence:
NW_006921683 Unplaced Scaffold Reference OryAfe1.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables ryanodine-sensitive calcium-release channel activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in calcium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in intracellular calcium ion homeostasis IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in Z disc IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of calcium channel complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in sarcolemma IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in sarcoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in smooth endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
ryanodine receptor 2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Orycteropus afer afer Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference OryAfe1.0 Primary Assembly

Genomic

  1. NW_006921683.1 Reference OryAfe1.0 Primary Assembly

    Range
    418098..1518076
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_007942720.1 → XP_007940911.1  ryanodine receptor 2

    UniProtKB/TrEMBL
    A0A8B7A406
    Conserved Domains (13) summary
    smart00472
    Location:361 → 451
    MIR; Domain in ryanodine and inositol trisphosphate receptors and protein O-mannosyltransferases
    cd12877
    Location:729 → 880
    SPRY1_RyR; SPRY domain 1 (SPRY1) of ryanodine receptor (RyR)
    cd12878
    Location:1161 → 1293
    SPRY2_RyR; SPRY domain 2 (SPRY2) of ryanodine receptor (RyR)
    pfam00520
    Location:4782 → 4942
    Ion_trans; Ion transport protein
    pfam01365
    Location:530 → 718
    RYDR_ITPR; RIH domain
    pfam02026
    Location:2776 → 2866
    RyR; RyR domain
    pfam02815
    Location:301 → 481
    MIR; MIR domain
    pfam06459
    Location:4397 → 4663
    RR_TM4-6; Ryanodine Receptor TM 4-6
    pfam08454
    Location:3899 → 4012
    RIH_assoc; RyR and IP3R Homology associated
    pfam13499
    Location:4094 → 4151
    EF-hand_7; EF-hand domain pair
    cd12879
    Location:1487 → 1633
    SPRY3_RyR; SPRY domain 3 (SPRY3) of ryanodine receptor (RyR)
    cl08302
    Location:4094 → 4149
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cl19745
    Location:103 → 291
    Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor
Nucleotide Protein
Heading Accession and Version

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