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Ryr2 ryanodine receptor 2, cardiac [ Mus musculus (house mouse) ]

Gene ID: 20191, updated on 5-Jan-2022

Summary

Official Symbol
Ryr2provided by MGI
Official Full Name
ryanodine receptor 2, cardiacprovided by MGI
Primary source
MGI:MGI:99685
See related
Ensembl:ENSMUSG00000021313
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
RYR-2; 9330127I20Rik
Summary
Enables several functions, including calmodulin binding activity; identical protein binding activity; and ryanodine-sensitive calcium-release channel activity. Involved in several processes, including cellular response to organonitrogen compound; regulation of heart contraction; and release of sequestered calcium ion into cytosol by sarcoplasmic reticulum. Acts upstream of or within several processes, including calcium ion transport; left ventricular cardiac muscle tissue morphogenesis; and response to caffeine. Located in Z disc; sarcoplasmic reticulum membrane; and smooth endoplasmic reticulum. Part of calcium channel complex. Is expressed in several structures, including brain; cardiovascular system; genitourinary system; gut; and respiratory system. Used to study arrhythmogenic right ventricular dysplasia 2; catecholaminergic polymorphic ventricular tachycardia 1; and heart disease. Human ortholog(s) of this gene implicated in arrhythmogenic right ventricular cardiomyopathy; arrhythmogenic right ventricular dysplasia 2; and catecholaminergic polymorphic ventricular tachycardia 1. Orthologous to human RYR2 (ryanodine receptor 2). [provided by Alliance of Genome Resources, Nov 2021]
Expression
Biased expression in heart adult (RPKM 43.4), cortex adult (RPKM 7.6) and 3 other tissues See more
Orthologs
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Genomic context

See Ryr2 in Genome Data Viewer
Location:
13 A1; 13 4.38 cM
Exon count:
108
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (11567985..12121831, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (11553099..12106945, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 13 NC_000079.5 (11645370..12199212, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 25496 Neighboring gene zona pellucida glycoprotein 4, pseudogene Neighboring gene ribosomal protein S7 pseudogene Neighboring gene predicted gene 10336 Neighboring gene 5-methyltetrahydrofolate-homocysteine methyltransferase

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium channel activity IDA
Inferred from Direct Assay
more info
PubMed 
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables calcium-induced calcium release activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables calcium-induced calcium release activity ISO
Inferred from Sequence Orthology
more info
 
enables calcium-release channel activity IDA
Inferred from Direct Assay
more info
PubMed 
enables calcium-release channel activity ISO
Inferred from Sequence Orthology
more info
 
enables calmodulin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables calmodulin binding ISO
Inferred from Sequence Orthology
more info
 
enables enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables ion channel activity IEA
Inferred from Electronic Annotation
more info
 
enables organic cyclic compound binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase A catalytic subunit binding ISO
Inferred from Sequence Orthology
more info
 
enables protein kinase A regulatory subunit binding ISO
Inferred from Sequence Orthology
more info
 
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein self-association IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables ryanodine-sensitive calcium-release channel activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ryanodine-sensitive calcium-release channel activity IDA
Inferred from Direct Assay
more info
PubMed 
enables ryanodine-sensitive calcium-release channel activity ISO
Inferred from Sequence Orthology
more info
 
enables scaffold protein binding ISO
Inferred from Sequence Orthology
more info
 
enables suramin binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in Purkinje myocyte to ventricular cardiac muscle cell signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within calcium ion transmembrane transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in calcium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within calcium ion transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in calcium ion transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in calcium ion transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within calcium ion transport IPI
Inferred from Physical Interaction
more info
PubMed 
involved_in calcium ion transport ISO
Inferred from Sequence Orthology
more info
 
involved_in calcium ion transport into cytosol ISO
Inferred from Sequence Orthology
more info
 
involved_in calcium-mediated signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in calcium-mediated signaling using intracellular calcium source ISO
Inferred from Sequence Orthology
more info
 
involved_in cardiac muscle contraction ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cardiac muscle hypertrophy IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular calcium ion homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cellular response to caffeine IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to caffeine IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to caffeine ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to epinephrine stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cytosolic calcium ion transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in detection of calcium ion ISO
Inferred from Sequence Orthology
more info
 
involved_in embryonic heart tube morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in establishment of protein localization to endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
involved_in ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in ion transport IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within left ventricular cardiac muscle tissue morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in manganese ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of cytosolic calcium ion concentration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of ATPase-coupled calcium transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of heart rate IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of sequestering of calcium ion ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of the force of heart contraction ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of AV node cell action potential ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of SA node cell action potential ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of atrial cardiac muscle cell action potential ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cardiac muscle contraction ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cardiac muscle contraction by calcium ion signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of cytosolic calcium ion concentration ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of heart rate IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of heart rate ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of ventricular cardiac muscle cell action potential ISO
Inferred from Sequence Orthology
more info
 
involved_in release of sequestered calcium ion into cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in release of sequestered calcium ion into cytosol ISO
Inferred from Sequence Orthology
more info
 
involved_in release of sequestered calcium ion into cytosol by sarcoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within release of sequestered calcium ion into cytosol by sarcoplasmic reticulum IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in release of sequestered calcium ion into cytosol by sarcoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within response to caffeine IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to caffeine IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to caffeine ISO
Inferred from Sequence Orthology
more info
 
involved_in response to calcium ion ISO
Inferred from Sequence Orthology
more info
 
involved_in response to hypoxia IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to magnesium ion ISO
Inferred from Sequence Orthology
more info
 
involved_in response to muscle activity ISO
Inferred from Sequence Orthology
more info
 
involved_in response to muscle stretch ISO
Inferred from Sequence Orthology
more info
 
involved_in response to redox state ISO
Inferred from Sequence Orthology
more info
 
involved_in sarcoplasmic reticulum calcium ion transport ISO
Inferred from Sequence Orthology
more info
 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in type B pancreatic cell apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in type B pancreatic cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in ventricular cardiac muscle cell action potential IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in A band ISO
Inferred from Sequence Orthology
more info
 
is_active_in Z disc IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in Z disc IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with Z disc ISO
Inferred from Sequence Orthology
more info
 
located_in Z disc ISO
Inferred from Sequence Orthology
more info
 
part_of calcium channel complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of calcium channel complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of calcium channel complex ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasmic vesicle membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
located_in extrinsic component of cytoplasmic side of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in integral component of membrane IC
Inferred by Curator
more info
PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
located_in neuron projection ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear envelope ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
PubMed 
is_active_in sarcolemma IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in sarcolemma ISO
Inferred from Sequence Orthology
more info
 
located_in sarcomere IDA
Inferred from Direct Assay
more info
PubMed 
located_in sarcoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
located_in sarcoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
is_active_in sarcoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in sarcoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in sarcoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in smooth endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in smooth endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
ryanodine receptor 2
Names
calcium release channel
cardiac muscle ryanodine receptor
cardiac muscle ryanodine receptor-calcium release channel
ryanodine receptor type 2
type 2 ryanodine receptor

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_023868.2NP_076357.2  ryanodine receptor 2

    See identical proteins and their annotated locations for NP_076357.2

    Status: VALIDATED

    Source sequence(s)
    AC131329, AC159208, AF295105, BB387101, BC059061, BU921357, U23755
    Consensus CDS
    CCDS49206.1
    UniProtKB/Swiss-Prot
    E9Q401
    UniProtKB/TrEMBL
    Q60835, Q80ZZ5
    Related
    ENSMUSP00000021750.8, ENSMUST00000021750.15
    Conserved Domains (11) summary
    cd12877
    Location:654805
    SPRY1_RyR; SPRY domain 1 (SPRY1) of ryanodine receptor (RyR)
    cd12878
    Location:10861218
    SPRY2_RyR; SPRY domain 2 (SPRY2) of ryanodine receptor (RyR)
    cd12879
    Location:14121559
    SPRY3_RyR; SPRY domain 3 (SPRY3) of ryanodine receptor (RyR)
    pfam00520
    Location:47174877
    Ion_trans; Ion transport protein
    pfam01365
    Location:455648
    RYDR_ITPR; RIH domain
    pfam02026
    Location:27002790
    RyR; RyR domain
    pfam02815
    Location:226406
    MIR; MIR domain
    pfam06459
    Location:43334598
    RR_TM4-6; Ryanodine Receptor TM 4-6
    pfam08454
    Location:38303947
    RIH_assoc; RyR and IP3R Homology associated
    pfam13499
    Location:40314086
    EF-hand_7; EF-hand domain pair
    cl19745
    Location:9222
    Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    11567985..12121831 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017315461.2XP_017170950.1  ryanodine receptor 2 isoform X17

    Conserved Domains (11) summary
    cd12877
    Location:642793
    SPRY1_RyR; SPRY domain 1 (SPRY1) of ryanodine receptor (RyR)
    cd12878
    Location:10741206
    SPRY2_RyR; SPRY domain 2 (SPRY2) of ryanodine receptor (RyR)
    cd12879
    Location:14001547
    SPRY3_RyR; SPRY domain 3 (SPRY3) of ryanodine receptor (RyR)
    pfam00520
    Location:47044864
    Ion_trans; Ion transport protein
    pfam01365
    Location:444636
    RYDR_ITPR; RIH domain
    pfam02026
    Location:26882778
    RyR; RyR domain
    pfam02815
    Location:214394
    MIR; MIR domain
    pfam06459
    Location:43194585
    RR_TM4-6; Ryanodine Receptor TM 4-6
    pfam08454
    Location:38213934
    RIH_assoc; RyR and IP3R Homology associated
    pfam13499
    Location:40184073
    EF-hand_7; EF-hand domain pair
    cl19745
    Location:13204
    Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor
  2. XM_006516610.2XP_006516673.1  ryanodine receptor 2 isoform X1

    Conserved Domains (11) summary
    cd12877
    Location:654805
    SPRY1_RyR; SPRY domain 1 (SPRY1) of ryanodine receptor (RyR)
    cd12878
    Location:10861218
    SPRY2_RyR; SPRY domain 2 (SPRY2) of ryanodine receptor (RyR)
    cd12879
    Location:14121559
    SPRY3_RyR; SPRY domain 3 (SPRY3) of ryanodine receptor (RyR)
    pfam00520
    Location:47364896
    Ion_trans; Ion transport protein
    pfam01365
    Location:456648
    RYDR_ITPR; RIH domain
    pfam02026
    Location:27002790
    RyR; RyR domain
    pfam02815
    Location:226406
    MIR; MIR domain
    pfam06459
    Location:43514617
    RR_TM4-6; Ryanodine Receptor TM 4-6
    pfam08454
    Location:38533966
    RIH_assoc; RyR and IP3R Homology associated
    pfam13499
    Location:40504105
    EF-hand_7; EF-hand domain pair
    cl19745
    Location:13216
    Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor
  3. XM_036157936.1XP_036013829.1  ryanodine receptor 2 isoform X8

    Conserved Domains (11) summary
    cd12877
    Location:642793
    SPRY1_RyR; SPRY domain 1 (SPRY1) of ryanodine receptor (RyR)
    cd12878
    Location:10741206
    SPRY2_RyR; SPRY domain 2 (SPRY2) of ryanodine receptor (RyR)
    cd12879
    Location:14001547
    SPRY3_RyR; SPRY domain 3 (SPRY3) of ryanodine receptor (RyR)
    pfam00520
    Location:47244884
    Ion_trans; Ion transport protein
    pfam01365
    Location:443636
    RYDR_ITPR; RIH domain
    pfam02026
    Location:26882778
    RyR; RyR domain
    pfam02815
    Location:214394
    MIR; MIR domain
    pfam06459
    Location:43404605
    RR_TM4-6; Ryanodine Receptor TM 4-6
    pfam08454
    Location:38373954
    RIH_assoc; RyR and IP3R Homology associated
    pfam13499
    Location:40384093
    EF-hand_7; EF-hand domain pair
    cl19745
    Location:9210
    Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor
  4. XM_011244296.3XP_011242598.1  ryanodine receptor 2 isoform X15

    Conserved Domains (11) summary
    cd12877
    Location:647798
    SPRY1_RyR; SPRY domain 1 (SPRY1) of ryanodine receptor (RyR)
    cd12878
    Location:10791211
    SPRY2_RyR; SPRY domain 2 (SPRY2) of ryanodine receptor (RyR)
    cd12879
    Location:14051552
    SPRY3_RyR; SPRY domain 3 (SPRY3) of ryanodine receptor (RyR)
    pfam00520
    Location:46984858
    Ion_trans; Ion transport protein
    pfam01365
    Location:449641
    RYDR_ITPR; RIH domain
    pfam02026
    Location:26932783
    RyR; RyR domain
    pfam02815
    Location:219399
    MIR; MIR domain
    pfam06459
    Location:43134579
    RR_TM4-6; Ryanodine Receptor TM 4-6
    pfam08454
    Location:38153928
    RIH_assoc; RyR and IP3R Homology associated
    pfam13499
    Location:40124067
    EF-hand_7; EF-hand domain pair
    cl19745
    Location:13209
    Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor
  5. XM_017315455.3XP_017170944.1  ryanodine receptor 2 isoform X14

    Conserved Domains (11) summary
    cd12877
    Location:647798
    SPRY1_RyR; SPRY domain 1 (SPRY1) of ryanodine receptor (RyR)
    cd12878
    Location:10791211
    SPRY2_RyR; SPRY domain 2 (SPRY2) of ryanodine receptor (RyR)
    cd12879
    Location:14051552
    SPRY3_RyR; SPRY domain 3 (SPRY3) of ryanodine receptor (RyR)
    pfam00520
    Location:47064866
    Ion_trans; Ion transport protein
    pfam01365
    Location:449641
    RYDR_ITPR; RIH domain
    pfam02026
    Location:26932783
    RyR; RyR domain
    pfam02815
    Location:219399
    MIR; MIR domain
    pfam06459
    Location:43214587
    RR_TM4-6; Ryanodine Receptor TM 4-6
    pfam08454
    Location:38233936
    RIH_assoc; RyR and IP3R Homology associated
    pfam13499
    Location:40204075
    EF-hand_7; EF-hand domain pair
    cl19745
    Location:13209
    Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor
  6. XM_036157933.1XP_036013826.1  ryanodine receptor 2 isoform X4

    Conserved Domains (11) summary
    cd12877
    Location:647798
    SPRY1_RyR; SPRY domain 1 (SPRY1) of ryanodine receptor (RyR)
    cd12878
    Location:10791211
    SPRY2_RyR; SPRY domain 2 (SPRY2) of ryanodine receptor (RyR)
    cd12879
    Location:14051552
    SPRY3_RyR; SPRY domain 3 (SPRY3) of ryanodine receptor (RyR)
    pfam00520
    Location:47294889
    Ion_trans; Ion transport protein
    pfam01365
    Location:448641
    RYDR_ITPR; RIH domain
    pfam02026
    Location:26932783
    RyR; RyR domain
    pfam02815
    Location:219399
    MIR; MIR domain
    pfam06459
    Location:43454610
    RR_TM4-6; Ryanodine Receptor TM 4-6
    pfam08454
    Location:38423959
    RIH_assoc; RyR and IP3R Homology associated
    pfam13499
    Location:40434098
    EF-hand_7; EF-hand domain pair
    cl19745
    Location:9215
    Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor
  7. XM_036157938.1XP_036013831.1  ryanodine receptor 2 isoform X10

    Conserved Domains (11) summary
    cd12877
    Location:654805
    SPRY1_RyR; SPRY domain 1 (SPRY1) of ryanodine receptor (RyR)
    cd12878
    Location:10861218
    SPRY2_RyR; SPRY domain 2 (SPRY2) of ryanodine receptor (RyR)
    cd12879
    Location:14121559
    SPRY3_RyR; SPRY domain 3 (SPRY3) of ryanodine receptor (RyR)
    pfam00520
    Location:47164876
    Ion_trans; Ion transport protein
    pfam01365
    Location:455648
    RYDR_ITPR; RIH domain
    pfam02026
    Location:27002790
    RyR; RyR domain
    pfam02815
    Location:226406
    MIR; MIR domain
    pfam06459
    Location:43324597
    RR_TM4-6; Ryanodine Receptor TM 4-6
    pfam08454
    Location:38293946
    RIH_assoc; RyR and IP3R Homology associated
    pfam13499
    Location:40304085
    EF-hand_7; EF-hand domain pair
    cl19745
    Location:9222
    Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor
  8. XM_036157940.1XP_036013833.1  ryanodine receptor 2 isoform X12

    Conserved Domains (11) summary
    cd12877
    Location:654805
    SPRY1_RyR; SPRY domain 1 (SPRY1) of ryanodine receptor (RyR)
    cd12878
    Location:10861218
    SPRY2_RyR; SPRY domain 2 (SPRY2) of ryanodine receptor (RyR)
    cd12879
    Location:14121559
    SPRY3_RyR; SPRY domain 3 (SPRY3) of ryanodine receptor (RyR)
    pfam00520
    Location:47134873
    Ion_trans; Ion transport protein
    pfam01365
    Location:455648
    RYDR_ITPR; RIH domain
    pfam02026
    Location:27002790
    RyR; RyR domain
    pfam02815
    Location:226406
    MIR; MIR domain
    pfam06459
    Location:43294594
    RR_TM4-6; Ryanodine Receptor TM 4-6
    pfam08454
    Location:38263943
    RIH_assoc; RyR and IP3R Homology associated
    pfam13499
    Location:40274082
    EF-hand_7; EF-hand domain pair
    cl19745
    Location:9222
    Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor
  9. XM_036157935.1XP_036013828.1  ryanodine receptor 2 isoform X7

    Conserved Domains (11) summary
    cd12877
    Location:654805
    SPRY1_RyR; SPRY domain 1 (SPRY1) of ryanodine receptor (RyR)
    cd12878
    Location:10861218
    SPRY2_RyR; SPRY domain 2 (SPRY2) of ryanodine receptor (RyR)
    cd12879
    Location:14121559
    SPRY3_RyR; SPRY domain 3 (SPRY3) of ryanodine receptor (RyR)
    pfam00520
    Location:47244884
    Ion_trans; Ion transport protein
    pfam01365
    Location:455648
    RYDR_ITPR; RIH domain
    pfam02026
    Location:27002790
    RyR; RyR domain
    pfam02815
    Location:226406
    MIR; MIR domain
    pfam06459
    Location:43404605
    RR_TM4-6; Ryanodine Receptor TM 4-6
    pfam08454
    Location:38373954
    RIH_assoc; RyR and IP3R Homology associated
    pfam13499
    Location:40384093
    EF-hand_7; EF-hand domain pair
    cl19745
    Location:9222
    Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor
  10. XM_036157941.1XP_036013834.1  ryanodine receptor 2 isoform X13

    Conserved Domains (11) summary
    cd12877
    Location:654805
    SPRY1_RyR; SPRY domain 1 (SPRY1) of ryanodine receptor (RyR)
    cd12878
    Location:10861218
    SPRY2_RyR; SPRY domain 2 (SPRY2) of ryanodine receptor (RyR)
    cd12879
    Location:14121559
    SPRY3_RyR; SPRY domain 3 (SPRY3) of ryanodine receptor (RyR)
    pfam00520
    Location:47114871
    Ion_trans; Ion transport protein
    pfam01365
    Location:455648
    RYDR_ITPR; RIH domain
    pfam02026
    Location:27002790
    RyR; RyR domain
    pfam02815
    Location:226406
    MIR; MIR domain
    pfam06459
    Location:43334592
    RR_TM4-6; Ryanodine Receptor TM 4-6
    pfam08454
    Location:38303947
    RIH_assoc; RyR and IP3R Homology associated
    pfam13499
    Location:40314086
    EF-hand_7; EF-hand domain pair
    cl19745
    Location:9222
    Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor
  11. XM_036157939.1XP_036013832.1  ryanodine receptor 2 isoform X11

    Conserved Domains (11) summary
    cd12877
    Location:654805
    SPRY1_RyR; SPRY domain 1 (SPRY1) of ryanodine receptor (RyR)
    cd12878
    Location:10861218
    SPRY2_RyR; SPRY domain 2 (SPRY2) of ryanodine receptor (RyR)
    cd12879
    Location:14121559
    SPRY3_RyR; SPRY domain 3 (SPRY3) of ryanodine receptor (RyR)
    pfam00520
    Location:47154875
    Ion_trans; Ion transport protein
    pfam01365
    Location:455648
    RYDR_ITPR; RIH domain
    pfam02026
    Location:27002790
    RyR; RyR domain
    pfam02815
    Location:226406
    MIR; MIR domain
    pfam06459
    Location:43334596
    RR_TM4-6; Ryanodine Receptor TM 4-6
    pfam08454
    Location:38303947
    RIH_assoc; RyR and IP3R Homology associated
    pfam13499
    Location:40314086
    EF-hand_7; EF-hand domain pair
    cl19745
    Location:9222
    Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor
  12. XM_036157934.1XP_036013827.1  ryanodine receptor 2 isoform X5

    Conserved Domains (11) summary
    cd12877
    Location:654805
    SPRY1_RyR; SPRY domain 1 (SPRY1) of ryanodine receptor (RyR)
    cd12878
    Location:10861218
    SPRY2_RyR; SPRY domain 2 (SPRY2) of ryanodine receptor (RyR)
    cd12879
    Location:14121559
    SPRY3_RyR; SPRY domain 3 (SPRY3) of ryanodine receptor (RyR)
    pfam00520
    Location:47284888
    Ion_trans; Ion transport protein
    pfam01365
    Location:455648
    RYDR_ITPR; RIH domain
    pfam02026
    Location:27002790
    RyR; RyR domain
    pfam02815
    Location:226406
    MIR; MIR domain
    pfam06459
    Location:43444609
    RR_TM4-6; Ryanodine Receptor TM 4-6
    pfam08454
    Location:38413958
    RIH_assoc; RyR and IP3R Homology associated
    pfam13499
    Location:40424097
    EF-hand_7; EF-hand domain pair
    cl19745
    Location:9222
    Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor
  13. XM_036157937.1XP_036013830.1  ryanodine receptor 2 isoform X9

    Conserved Domains (11) summary
    cd12877
    Location:654805
    SPRY1_RyR; SPRY domain 1 (SPRY1) of ryanodine receptor (RyR)
    cd12878
    Location:10861218
    SPRY2_RyR; SPRY domain 2 (SPRY2) of ryanodine receptor (RyR)
    cd12879
    Location:14121559
    SPRY3_RyR; SPRY domain 3 (SPRY3) of ryanodine receptor (RyR)
    pfam00520
    Location:47194879
    Ion_trans; Ion transport protein
    pfam01365
    Location:455648
    RYDR_ITPR; RIH domain
    pfam02026
    Location:27002790
    RyR; RyR domain
    pfam02815
    Location:226406
    MIR; MIR domain
    pfam06459
    Location:43414600
    RR_TM4-6; Ryanodine Receptor TM 4-6
    pfam08454
    Location:38383955
    RIH_assoc; RyR and IP3R Homology associated
    pfam13499
    Location:40394094
    EF-hand_7; EF-hand domain pair
    cl19745
    Location:9222
    Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor
  14. XM_017315460.3XP_017170949.1  ryanodine receptor 2 isoform X6

    Conserved Domains (11) summary
    cd12877
    Location:654805
    SPRY1_RyR; SPRY domain 1 (SPRY1) of ryanodine receptor (RyR)
    cd12878
    Location:10861218
    SPRY2_RyR; SPRY domain 2 (SPRY2) of ryanodine receptor (RyR)
    cd12879
    Location:14121559
    SPRY3_RyR; SPRY domain 3 (SPRY3) of ryanodine receptor (RyR)
    pfam00520
    Location:47254885
    Ion_trans; Ion transport protein
    pfam01365
    Location:456648
    RYDR_ITPR; RIH domain
    pfam02026
    Location:27002790
    RyR; RyR domain
    pfam02815
    Location:226406
    MIR; MIR domain
    pfam06459
    Location:43404606
    RR_TM4-6; Ryanodine Receptor TM 4-6
    pfam08454
    Location:38423955
    RIH_assoc; RyR and IP3R Homology associated
    pfam13499
    Location:40394094
    EF-hand_7; EF-hand domain pair
    cl19745
    Location:13216
    Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor
  15. XM_036157932.1XP_036013825.1  ryanodine receptor 2 isoform X3

    Conserved Domains (11) summary
    cd12877
    Location:654805
    SPRY1_RyR; SPRY domain 1 (SPRY1) of ryanodine receptor (RyR)
    cd12878
    Location:10861218
    SPRY2_RyR; SPRY domain 2 (SPRY2) of ryanodine receptor (RyR)
    cd12879
    Location:14121559
    SPRY3_RyR; SPRY domain 3 (SPRY3) of ryanodine receptor (RyR)
    pfam00520
    Location:47304890
    Ion_trans; Ion transport protein
    pfam01365
    Location:455648
    RYDR_ITPR; RIH domain
    pfam02026
    Location:27002790
    RyR; RyR domain
    pfam02815
    Location:226406
    MIR; MIR domain
    pfam06459
    Location:43524611
    RR_TM4-6; Ryanodine Receptor TM 4-6
    pfam08454
    Location:38493966
    RIH_assoc; RyR and IP3R Homology associated
    pfam13499
    Location:40504105
    EF-hand_7; EF-hand domain pair
    cl19745
    Location:9222
    Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor
  16. XM_036157931.1XP_036013824.1  ryanodine receptor 2 isoform X2

    Conserved Domains (11) summary
    cd12877
    Location:654805
    SPRY1_RyR; SPRY domain 1 (SPRY1) of ryanodine receptor (RyR)
    cd12878
    Location:10861218
    SPRY2_RyR; SPRY domain 2 (SPRY2) of ryanodine receptor (RyR)
    cd12879
    Location:14121559
    SPRY3_RyR; SPRY domain 3 (SPRY3) of ryanodine receptor (RyR)
    pfam00520
    Location:47344894
    Ion_trans; Ion transport protein
    pfam01365
    Location:455648
    RYDR_ITPR; RIH domain
    pfam02026
    Location:27002790
    RyR; RyR domain
    pfam02815
    Location:226406
    MIR; MIR domain
    pfam06459
    Location:43524615
    RR_TM4-6; Ryanodine Receptor TM 4-6
    pfam08454
    Location:38493966
    RIH_assoc; RyR and IP3R Homology associated
    pfam13499
    Location:40504105
    EF-hand_7; EF-hand domain pair
    cl19745
    Location:9222
    Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor
  17. XM_036157942.1XP_036013835.1  ryanodine receptor 2 isoform X16

    Conserved Domains (7) summary
    cd12877
    Location:654805
    SPRY1_RyR; SPRY domain 1 (SPRY1) of ryanodine receptor (RyR)
    cd12878
    Location:10861218
    SPRY2_RyR; SPRY domain 2 (SPRY2) of ryanodine receptor (RyR)
    cd12879
    Location:14121559
    SPRY3_RyR; SPRY domain 3 (SPRY3) of ryanodine receptor (RyR)
    pfam01365
    Location:455648
    RYDR_ITPR; RIH domain
    pfam02026
    Location:27002790
    RyR; RyR domain
    pfam02815
    Location:226406
    MIR; MIR domain
    cl19745
    Location:9222
    Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor

RNA

  1. XR_004937983.1 RNA Sequence

  2. XR_004937984.1 RNA Sequence

  3. XR_004937985.1 RNA Sequence

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