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NTRK2 neurotrophic receptor tyrosine kinase 2 [ Orycteropus afer afer ]

Gene ID: 103195413, updated on 11-Apr-2024

Summary

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Gene symbol
NTRK2
Gene description
neurotrophic receptor tyrosine kinase 2
Gene type
protein coding
RefSeq status
MODEL
Organism
Orycteropus afer afer (sub-species: afer)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Afrotheria; Tubulidentata; Orycteropodidae; Orycteropus
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: Un
Exon count:
18
Annotation release Status Assembly Chr Location
101 current OryAfe1.0 (GCF_000298275.1) Unplaced Scaffold NW_006921592.1 (20679513..21179124)

NW_006921592.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 28 member 3 Neighboring gene U6 spliceosomal RNA Neighboring gene protein strawberry notch homolog 1-like Neighboring gene ATP/GTP binding carboxypeptidase 1

Genomic regions, transcripts, and products

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Genomic Sequence:
NW_006921592 Unplaced Scaffold Reference OryAfe1.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables brain-derived neurotrophic factor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables brain-derived neurotrophic factor receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell surface receptor protein tyrosine kinase signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cellular response to brain-derived neurotrophic factor stimulus IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in multicellular organism development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in trans-synaptic signaling by neuropeptide, modulating synaptic transmission IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in axon IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of receptor complex IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
BDNF/NT-3 growth factors receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Orycteropus afer afer Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference OryAfe1.0 Primary Assembly

Genomic

  1. NW_006921592.1 Reference OryAfe1.0 Primary Assembly

    Range
    20679513..21179124
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_007938966.2 → XP_007937157.1  BDNF/NT-3 growth factors receptor

    UniProtKB/TrEMBL
    A0A8B6ZN91, A0A8B6ZPX7
    Conserved Domains (7) summary
    cd05855
    Location:301 → 379
    Ig_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB
    smart00408
    Location:210 → 273
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:204 → 283
    IG_like; Immunoglobulin like
    cd05093
    Location:548 → 835
    PTKc_TrkB; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase B
    pfam07714
    Location:554 → 823
    Pkinase_Tyr; Protein tyrosine kinase
    pfam13855
    Location:92 → 150
    LRR_8; Leucine rich repeat
    pfam16920
    Location:152 → 195
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
Nucleotide Protein
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