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LIG4 DNA ligase 4 [ Orycteropus afer afer ]

Gene ID: 103195374, updated on 11-Mar-2024

Summary

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Gene symbol
LIG4
Gene description
DNA ligase 4
Gene type
protein coding
RefSeq status
MODEL
Organism
Orycteropus afer afer (sub-species: afer)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Afrotheria; Tubulidentata; Orycteropodidae; Orycteropus
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: Un
Exon count:
1
Annotation release Status Assembly Chr Location
101 current OryAfe1.0 (GCF_000298275.1) Unplaced Scaffold NW_006921642.1 (5107375..5110122)

NW_006921642.1Genomic Context describing neighboring genes Neighboring gene TNF superfamily member 13b Neighboring gene abhydrolase domain containing 13 Neighboring gene U6 spliceosomal RNA Neighboring gene nucleophosmin-like

Genomic regions, transcripts, and products

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Genomic Sequence:
NW_006921642 Unplaced Scaffold Reference OryAfe1.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables DNA ligase (ATP) activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in DNA ligation involved in DNA repair IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in double-strand break repair via nonhomologous end joining IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in immunoglobulin V(D)J recombination IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in nucleotide-excision repair, DNA gap filling IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of DNA ligase IV complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of DNA-dependent protein kinase-DNA ligase 4 complex IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
DNA ligase 4

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Orycteropus afer afer Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference OryAfe1.0 Primary Assembly

Genomic

  1. NW_006921642.1 Reference OryAfe1.0 Primary Assembly

    Range
    5107375..5110122
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_007938917.2 → XP_007937108.1  DNA ligase 4

    UniProtKB/TrEMBL
    A0A8B6ZN33
    Conserved Domains (7) summary
    cd07968
    Location:462 → 599
    OBF_DNA_ligase_IV; The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase IV is a DNA-binding module that is part of the catalytic core unit
    cd07903
    Location:238 → 458
    Adenylation_DNA_ligase_IV; Adenylation domain of DNA Ligase IV
    cd00027
    Location:849 → 903
    BRCT; Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo ...
    TIGR00574
    Location:84 → 605
    dnl1; DNA ligase I, ATP-dependent (dnl1)
    pfam00533
    Location:658 → 734
    BRCT; BRCA1 C Terminus (BRCT) domain
    pfam04675
    Location:18 → 206
    DNA_ligase_A_N; DNA ligase N terminus
    pfam11411
    Location:754 → 787
    DNA_ligase_IV; DNA ligase IV
Nucleotide Protein
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