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LIG4 DNA ligase 4 [ Homo sapiens (human) ]

Gene ID: 3981, updated on 7-Apr-2025

Summary

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Official Symbol
LIG4provided by HGNC
Official Full Name
DNA ligase 4provided by HGNC
Primary source
HGNC:HGNC:6601
See related
Ensembl:ENSG00000174405 MIM:601837; AllianceGenome:HGNC:6601
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LIG4S
Summary
The protein encoded by this gene is a DNA ligase that joins single-strand breaks in a double-stranded polydeoxynucleotide in an ATP-dependent reaction. This protein is essential for V(D)J recombination and DNA double-strand break (DSB) repair through nonhomologous end joining (NHEJ). This protein forms a complex with the X-ray repair cross complementing protein 4 (XRCC4), and further interacts with the DNA-dependent protein kinase (DNA-PK). Both XRCC4 and DNA-PK are known to be required for NHEJ. The crystal structure of the complex formed by this protein and XRCC4 has been resolved. Defects in this gene are the cause of LIG4 syndrome. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in brain (RPKM 5.8), testis (RPKM 4.8) and 25 other tissues See more
Orthologs
mouse all
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Genomic context

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See LIG4 in Genome Data Viewer
Location:
13q33.3
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 13 NC_000013.11 (108207442..108218349, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 13 NC_060937.1 (107433544..107444540, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (108859790..108870697, complement)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene NALCN channel auxiliary factor 1 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_31956 Neighboring gene NALF1 intronic transcript 1 Neighboring gene heparan sulfate glucosamine 3-O-sulfotransferase 4-like Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:108520312-108520880 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:108527353-108527854 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:108527855-108528354 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_32038 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_32053 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:108578206-108578800 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_32153 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_32158 Neighboring gene ReSE screen-validated silencer GRCh37_chr13:108751669-108751831 Neighboring gene ReSE screen-validated silencer GRCh37_chr13:108830918-108831040 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:108846907-108847407 Neighboring gene Sharpr-MPRA regulatory region 13792 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7987 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5495 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7988 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:108922483-108922991 Neighboring gene abhydrolase domain containing 13 Neighboring gene TNF superfamily member 13b Neighboring gene RNA, 5S ribosomal pseudogene 39

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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Related articles in PubMed

  1. DNA ligase4 as a prognostic marker in nasopharyngeal cancer patients treated with radiotherapy. Kim DH, et al. Asian Pac J Cancer Prev, 2014. PMID 25605214
  2. Polymorphisms in the DNA ligase IV gene might influence the risk of acute lymphoblastic leukemia in children. Andreae J, et al. Leukemia, 2007 Oct. PMID 17541392
  3. Ligase IV syndrome can present with microcephaly and radial ray anomalies similar to Fanconi anaemia plus fatal kidney malformations. Madhu R, et al. Eur J Med Genet, 2020 Sep. PMID 32534991, Free PMC Article
  4. Analysis of DNA ligase IV mutations found in LIG4 syndrome patients: the impact of two linked polymorphisms. Girard PM, et al. Hum Mol Genet, 2004 Oct 15. PMID 15333585
  5. DNA Ligase IV regulates XRCC4 nuclear localization. Francis DB, et al. DNA Repair (Amst), 2014 Sep. PMID 24984242, Free PMC Article

See all (213) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Critical residues in the Ku70 von Willebrand A domain mediate Ku interaction with the LigIV-XRCC4 complex in non-homologous end-joining.
    Title: Critical residues in the Ku70 von Willebrand A domain mediate Ku interaction with the LigIV-XRCC4 complex in non-homologous end-joining.
  2. Expanding the phenotypic spectrum of LIG4 pathogenic variations: neuro-histopathological description of 4 fetuses with stenosis of the aqueduct.
    Title: Expanding the phenotypic spectrum of LIG4 pathogenic variations: neuro-histopathological description of 4 fetuses with stenosis of the aqueduct.
  3. Deficiency of ligase IV leads to reduced NHEJ, accumulation of DNA damage, and can sensitize cells to cancer therapeutics.
    Title: Deficiency of ligase IV leads to reduced NHEJ, accumulation of DNA damage, and can sensitize cells to cancer therapeutics.
  4. The Contribution of DNA Ligase 4 Polymorphisms to Colorectal Cancer.
    Title: The Contribution of DNA Ligase 4 Polymorphisms to Colorectal Cancer.
  5. Autoimmunity and immunodeficiency associated with monoallelic LIG4 mutations via haploinsufficiency.
    Title: Autoimmunity and immunodeficiency associated with monoallelic LIG4 mutations via haploinsufficiency.
  6. The Contribution of DNA Ligase 4 Genetic Variations to Taiwanese Lung Cancer.
    Title: The Contribution of DNA Ligase 4 Genetic Variations to Taiwanese Lung Cancer.
  7. [Correlation of polymorphisms of DNA double-strand break repair genes XRCC5, LIG4 and glioma].
    Title: [Correlation of polymorphisms of DNA double-strand break repair genes XRCC5, LIG4 and glioma].
  8. USP39 promotes non-homologous end-joining repair by poly(ADP-ribose)-induced liquid demixing.
    Title: USP39 promotes non-homologous end-joining repair by poly(ADP-ribose)-induced liquid demixing.
  9. Characterization of a Cohort of Patients With LIG4 Deficiency Reveals the Founder Effect of p.R278L, Unique to the Chinese Population.
    Title: Characterization of a Cohort of Patients With LIG4 Deficiency Reveals the Founder Effect of p.R278L, Unique to the Chinese Population.
  10. Hypomorphic mutations in human DNA ligase IV lead to compromised DNA binding efficiency, hydrophobicity and thermal stability.
    Title: Hypomorphic mutations in human DNA ligase IV lead to compromised DNA binding efficiency, hydrophobicity and thermal stability.
Submit: New GeneRIF Correction See all GeneRIFs (106)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
DNA ligase IV deficiency
MedGen: C1847827 OMIM: 606593 GeneReviews: Not available
Compare labs
Multiple myeloma
MedGen: C0026764 OMIM: 254500 GeneReviews: Not available
Compare labs

EBI GWAS Catalog

Description
Conduct disorder and ADHD: evaluation of conduct problems as a categorical and quantitative trait in the international multicentre ADHD genetics study.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA ligase (ATP) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA ligase (ATP) activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA ligase (ATP) activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA ligase (ATP) activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables DNA ligase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA ligase activity TAS
Traceable Author Statement
more info
  
enables ligase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables magnesium ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within DN2 thymocyte differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA damage response IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA recombination IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within DNA repair IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
  
involved_in T cell differentiation in thymus ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within T cell receptor V(D)J recombination IEA
Inferred from Electronic Annotation
more info
  
involved_in T cell receptor V(D)J recombination ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in V(D)J recombination IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within V(D)J recombination IEA
Inferred from Electronic Annotation
more info
  
involved_in base-excision repair IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in cell population proliferation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in cellular response to ionizing radiation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in cellular response to lithium ion IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within central nervous system development IEA
Inferred from Electronic Annotation
more info
  
involved_in central nervous system development ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within chromosome organization IEA
Inferred from Electronic Annotation
more info
  
involved_in chromosome organization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in double-strand break repair IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within double-strand break repair IEA
Inferred from Electronic Annotation
more info
  
involved_in double-strand break repair ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in double-strand break repair via classical nonhomologous end joining IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in double-strand break repair via nonhomologous end joining IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in double-strand break repair via nonhomologous end joining IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within double-strand break repair via nonhomologous end joining IEA
Inferred from Electronic Annotation
more info
  
involved_in double-strand break repair via nonhomologous end joining IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in double-strand break repair via nonhomologous end joining IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in double-strand break repair via nonhomologous end joining TAS
Traceable Author Statement
more info
  
involved_in establishment of integrated proviral latency TAS
Traceable Author Statement
more info
  
acts_upstream_of fibroblast proliferation IEA
Inferred from Electronic Annotation
more info
  
involved_in immunoglobulin V(D)J recombination IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within immunoglobulin V(D)J recombination IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within in utero embryonic development IEA
Inferred from Electronic Annotation
more info
  
involved_in in utero embryonic development ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within isotype switching IEA
Inferred from Electronic Annotation
more info
  
involved_in isotype switching ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within negative regulation of neuron apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of neuron apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of neurogenesis IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of neuron apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in neuron apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in nucleotide-excision repair, DNA gap filling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nucleotide-excision repair, DNA gap filling IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of chromosome organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of fibroblast proliferation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of fibroblast proliferation ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within positive regulation of neurogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of neurogenesis ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within pro-B cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in pro-B cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in response to X-ray IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to gamma radiation IEA
Inferred from Electronic Annotation
more info
  
involved_in response to gamma radiation ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within response to ionizing radiation IEA
Inferred from Electronic Annotation
more info
  
involved_in single strand break repair IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within somatic stem cell population maintenance IEA
Inferred from Electronic Annotation
more info
  
involved_in somatic stem cell population maintenance ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within stem cell proliferation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of DNA ligase IV complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of DNA ligase IV complex IMP
Inferred from Mutant Phenotype
more info
 PubMed 
part_of DNA-dependent protein kinase-DNA ligase 4 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of DNA-dependent protein kinase-DNA ligase 4 complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of DNA-dependent protein kinase-DNA ligase 4 complex IEA
Inferred from Electronic Annotation
more info
  
part_of DNA-dependent protein kinase-DNA ligase 4 complex ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in chromosome, telomeric region IC
Inferred by Curator
more info
 PubMed 
located_in condensed chromosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
  
part_of nonhomologous end joining complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
is_active_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
DNA ligase 4
Names
DNA joinase
DNA ligase IV
DNA repair enzyme
ligase IV, DNA, ATP-dependent
polydeoxyribonucleotide synthase [ATP] 4
polynucleotide ligase
sealase
NP_001091738.1
NP_001317524.1
NP_001339527.1
NP_001339528.1
NP_001339529.1
NP_001339530.1
NP_001339531.1
NP_001339532.1
NP_001339533.1
NP_001366024.1
NP_002303.2
NP_996820.1

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_007396.1 RefSeqGene

    Range
    2167..13093
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_79

mRNA and Protein(s)

  1. NM_001098268.2 → NP_001091738.1  DNA ligase 4 isoform 1

    See identical proteins and their annotated locations for NP_001091738.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1-3 and 5-10 all encode the same isoform (1).
    Source sequence(s)
    BC037491, BX648833
    Consensus CDS
    CCDS9508.1
    UniProtKB/Swiss-Prot
    P49917, Q8IY66, Q8TEU5
    UniProtKB/TrEMBL
    B2RBW4
    Related
    ENSP00000385955.1, ENST00000405925.2
    Conserved Domains (4) summary
    TIGR00574
    Location:81 → 602
    dnl1; DNA ligase I, ATP-dependent (dnl1)
    cd17717
    Location:813 → 900
    BRCT_DNA_ligase_IV_rpt2; second BRCT domain of DNA ligase 4 (LIG4) and similar proteins
    cd17722
    Location:658 → 745
    BRCT_DNA_ligase_IV_rpt1; first BRCT domain of DNA ligase 4 (LIG4) and similar proteins
    pfam11411
    Location:750 → 783
    DNA_ligase_IV; DNA ligase IV

  2. NM_001330595.2 → NP_001317524.1  DNA ligase 4 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a dowstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus than isoform 1.
    Source sequence(s)
    AK292419, AL157762, BC037491, BX648833, DC372305
    Consensus CDS
    CCDS81779.1
    UniProtKB/TrEMBL
    A0A0C4DGV9, A8K8Q4
    Related
    ENSP00000480814.1, ENST00000614526.2

  3. NM_001352598.2 → NP_001339527.1  DNA ligase 4 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5), as well as variants 1-3 and 6-10, encodes isoform 1.
    Source sequence(s)
    AL157762
    Consensus CDS
    CCDS9508.1
    UniProtKB/Swiss-Prot
    P49917, Q8IY66, Q8TEU5
    UniProtKB/TrEMBL
    B2RBW4
    Related
    ENSP00000509502.1, ENST00000688595.1
    Conserved Domains (4) summary
    TIGR00574
    Location:81 → 602
    dnl1; DNA ligase I, ATP-dependent (dnl1)
    cd17717
    Location:813 → 900
    BRCT_DNA_ligase_IV_rpt2; second BRCT domain of DNA ligase 4 (LIG4) and similar proteins
    cd17722
    Location:658 → 745
    BRCT_DNA_ligase_IV_rpt1; first BRCT domain of DNA ligase 4 (LIG4) and similar proteins
    pfam11411
    Location:750 → 783
    DNA_ligase_IV; DNA ligase IV

  4. NM_001352599.2 → NP_001339528.1  DNA ligase 4 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6), as well as variants 1-3, 5, and 7-10, encodes isoform 1.
    Source sequence(s)
    AL157762
    Consensus CDS
    CCDS9508.1
    UniProtKB/Swiss-Prot
    P49917, Q8IY66, Q8TEU5
    UniProtKB/TrEMBL
    B2RBW4
    Related
    ENSP00000509564.1, ENST00000688396.1
    Conserved Domains (4) summary
    TIGR00574
    Location:81 → 602
    dnl1; DNA ligase I, ATP-dependent (dnl1)
    cd17717
    Location:813 → 900
    BRCT_DNA_ligase_IV_rpt2; second BRCT domain of DNA ligase 4 (LIG4) and similar proteins
    cd17722
    Location:658 → 745
    BRCT_DNA_ligase_IV_rpt1; first BRCT domain of DNA ligase 4 (LIG4) and similar proteins
    pfam11411
    Location:750 → 783
    DNA_ligase_IV; DNA ligase IV

  5. NM_001352600.2 → NP_001339529.1  DNA ligase 4 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7), as well as variants 1-3, 5, 6, and 8-10, encodes isoform 1.
    Source sequence(s)
    AL157762
    Consensus CDS
    CCDS9508.1
    UniProtKB/Swiss-Prot
    P49917, Q8IY66, Q8TEU5
    UniProtKB/TrEMBL
    B2RBW4
    Related
    ENSP00000509304.1, ENST00000688455.1
    Conserved Domains (4) summary
    TIGR00574
    Location:81 → 602
    dnl1; DNA ligase I, ATP-dependent (dnl1)
    cd17717
    Location:813 → 900
    BRCT_DNA_ligase_IV_rpt2; second BRCT domain of DNA ligase 4 (LIG4) and similar proteins
    cd17722
    Location:658 → 745
    BRCT_DNA_ligase_IV_rpt1; first BRCT domain of DNA ligase 4 (LIG4) and similar proteins
    pfam11411
    Location:750 → 783
    DNA_ligase_IV; DNA ligase IV

  6. NM_001352601.2 → NP_001339530.1  DNA ligase 4 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8), as well as variants 1-3, 5-7, 9, and 10, encodes isoform 1.
    Source sequence(s)
    AL157762
    Consensus CDS
    CCDS9508.1
    UniProtKB/Swiss-Prot
    P49917, Q8IY66, Q8TEU5
    UniProtKB/TrEMBL
    B2RBW4
    Related
    ENSP00000509906.1, ENST00000688529.1
    Conserved Domains (4) summary
    TIGR00574
    Location:81 → 602
    dnl1; DNA ligase I, ATP-dependent (dnl1)
    cd17717
    Location:813 → 900
    BRCT_DNA_ligase_IV_rpt2; second BRCT domain of DNA ligase 4 (LIG4) and similar proteins
    cd17722
    Location:658 → 745
    BRCT_DNA_ligase_IV_rpt1; first BRCT domain of DNA ligase 4 (LIG4) and similar proteins
    pfam11411
    Location:750 → 783
    DNA_ligase_IV; DNA ligase IV

  7. NM_001352602.2 → NP_001339531.1  DNA ligase 4 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9), as well as variants 1-3, 5-8, and 10, encodes isoform 1.
    Source sequence(s)
    AL157762
    Consensus CDS
    CCDS9508.1
    UniProtKB/Swiss-Prot
    P49917, Q8IY66, Q8TEU5
    UniProtKB/TrEMBL
    B2RBW4
    Related
    ENSP00000508512.1, ENST00000687164.1
    Conserved Domains (4) summary
    TIGR00574
    Location:81 → 602
    dnl1; DNA ligase I, ATP-dependent (dnl1)
    cd17717
    Location:813 → 900
    BRCT_DNA_ligase_IV_rpt2; second BRCT domain of DNA ligase 4 (LIG4) and similar proteins
    cd17722
    Location:658 → 745
    BRCT_DNA_ligase_IV_rpt1; first BRCT domain of DNA ligase 4 (LIG4) and similar proteins
    pfam11411
    Location:750 → 783
    DNA_ligase_IV; DNA ligase IV

  8. NM_001352603.1 → NP_001339532.1  DNA ligase 4 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10), as well as variants 1-3 and 5-9, encodes isoform 1.
    Source sequence(s)
    AL157762
    Consensus CDS
    CCDS9508.1
    UniProtKB/Swiss-Prot
    P49917, Q8IY66, Q8TEU5
    UniProtKB/TrEMBL
    B2RBW4
    Conserved Domains (4) summary
    TIGR00574
    Location:81 → 602
    dnl1; DNA ligase I, ATP-dependent (dnl1)
    cd17717
    Location:813 → 900
    BRCT_DNA_ligase_IV_rpt2; second BRCT domain of DNA ligase 4 (LIG4) and similar proteins
    cd17722
    Location:658 → 745
    BRCT_DNA_ligase_IV_rpt1; first BRCT domain of DNA ligase 4 (LIG4) and similar proteins
    pfam11411
    Location:750 → 783
    DNA_ligase_IV; DNA ligase IV

  9. NM_001352604.2 → NP_001339533.1  DNA ligase 4 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (11) encodes the longest isoform (3).
    Source sequence(s)
    AL157762
    UniProtKB/TrEMBL
    B2RBW4
    Conserved Domains (3) summary
    TIGR00574
    Location:93 → 614
    dnl1; DNA ligase I, ATP-dependent (dnl1)
    pfam00533
    Location:668 → 742
    BRCT; BRCA1 C Terminus (BRCT) domain
    pfam11411
    Location:762 → 795
    DNA_ligase_IV; DNA ligase IV

  10. NM_001379095.1 → NP_001366024.1  DNA ligase 4 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AL157762, DA211056
    Consensus CDS
    CCDS9508.1
    UniProtKB/Swiss-Prot
    P49917, Q8IY66, Q8TEU5
    UniProtKB/TrEMBL
    B2RBW4
    Related
    ENSP00000484288.1, ENST00000611712.4
    Conserved Domains (4) summary
    TIGR00574
    Location:81 → 602
    dnl1; DNA ligase I, ATP-dependent (dnl1)
    cd17717
    Location:813 → 900
    BRCT_DNA_ligase_IV_rpt2; second BRCT domain of DNA ligase 4 (LIG4) and similar proteins
    cd17722
    Location:658 → 745
    BRCT_DNA_ligase_IV_rpt1; first BRCT domain of DNA ligase 4 (LIG4) and similar proteins
    pfam11411
    Location:750 → 783
    DNA_ligase_IV; DNA ligase IV

  11. NM_002312.3 → NP_002303.2  DNA ligase 4 isoform 1

    See identical proteins and their annotated locations for NP_002303.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1), as well as variants 2, 3, and 5-10, encodes isoform 1.
    Source sequence(s)
    AI809944, BC037491, CD102896, X83441
    Consensus CDS
    CCDS9508.1
    UniProtKB/Swiss-Prot
    P49917, Q8IY66, Q8TEU5
    UniProtKB/TrEMBL
    B2RBW4
    Conserved Domains (4) summary
    TIGR00574
    Location:81 → 602
    dnl1; DNA ligase I, ATP-dependent (dnl1)
    cd17717
    Location:813 → 900
    BRCT_DNA_ligase_IV_rpt2; second BRCT domain of DNA ligase 4 (LIG4) and similar proteins
    cd17722
    Location:658 → 745
    BRCT_DNA_ligase_IV_rpt1; first BRCT domain of DNA ligase 4 (LIG4) and similar proteins
    pfam11411
    Location:750 → 783
    DNA_ligase_IV; DNA ligase IV

  12. NM_206937.2 → NP_996820.1  DNA ligase 4 isoform 1

    See identical proteins and their annotated locations for NP_996820.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1-3 and 5-10 all encode the same isoform (1).
    Source sequence(s)
    AL157762, BC037491, BX648833
    Consensus CDS
    CCDS9508.1
    UniProtKB/Swiss-Prot
    P49917, Q8IY66, Q8TEU5
    UniProtKB/TrEMBL
    B2RBW4
    Related
    ENSP00000402030.1, ENST00000442234.6
    Conserved Domains (4) summary
    TIGR00574
    Location:81 → 602
    dnl1; DNA ligase I, ATP-dependent (dnl1)
    cd17717
    Location:813 → 900
    BRCT_DNA_ligase_IV_rpt2; second BRCT domain of DNA ligase 4 (LIG4) and similar proteins
    cd17722
    Location:658 → 745
    BRCT_DNA_ligase_IV_rpt1; first BRCT domain of DNA ligase 4 (LIG4) and similar proteins
    pfam11411
    Location:750 → 783
    DNA_ligase_IV; DNA ligase IV

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p14 Primary Assembly

    Range
    108207442..108218349 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060937.1 Alternate T2T-CHM13v2.0

    Range
    107433544..107444540 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P49917.2 GenPept UniProtKB/Swiss-Prot:P49917

Gene LinkOut

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