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IDE insulin degrading enzyme [ Panthera tigris (tiger) ]

Gene ID: 102971779, updated on 10-Mar-2024

Summary

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Gene symbol
IDE
Gene description
insulin degrading enzyme
See related
Ensembl:ENSPTIG00000010712
Gene type
protein coding
RefSeq status
MODEL
Organism
Panthera tigris
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Pantherinae; Panthera
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: D2
Exon count:
34
Annotation release Status Assembly Chr Location
102 current P.tigris_Pti1_mat1.1 (GCF_018350195.1) D2 NC_056670.1 (51972330..52166465, complement)

Chromosome D2 - NC_056670.1Genomic Context describing neighboring genes Neighboring gene cytoplasmic polyadenylation element binding protein 3 Neighboring gene U6 spliceosomal RNA Neighboring gene 60S ribosomal protein L36a-like Neighboring gene membrane associated ring-CH-type finger 5 Neighboring gene uncharacterized LOC122232065 Neighboring gene kinesin family member 11 Neighboring gene uncharacterized LOC122231911 Neighboring gene hematopoietically expressed homeobox Neighboring gene exocyst complex component 6

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_056670.1 Chromosome D2 Reference P.tigris_Pti1_mat1.1 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables metalloendopeptidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in peptide catabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in proteolysis involved in protein catabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in peroxisomal matrix IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
insulin-degrading enzyme

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Panthera tigris Annotation Release 102 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference P.tigris_Pti1_mat1.1 Primary Assembly

Genomic

  1. NC_056670.1 Reference P.tigris_Pti1_mat1.1 Primary Assembly

    Range
    51972330..52166465 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_042961097.1 → XP_042817031.1  insulin-degrading enzyme isoform X4

    UniProtKB/TrEMBL
    A0A8C9JPL5
    Conserved Domains (1) summary
    COG1025
    Location:11 → 917
    Ptr; Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, protein turnover, chaperones]

  2. XM_042961096.1 → XP_042817030.1  insulin-degrading enzyme isoform X4

    UniProtKB/TrEMBL
    A0A8C9JPL5
    Conserved Domains (1) summary
    COG1025
    Location:11 → 917
    Ptr; Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, protein turnover, chaperones]

  3. XM_042961095.1 → XP_042817029.1  insulin-degrading enzyme isoform X4

    UniProtKB/TrEMBL
    A0A8C9JPL5
    Conserved Domains (1) summary
    COG1025
    Location:11 → 917
    Ptr; Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, protein turnover, chaperones]

  4. XM_042961100.1 → XP_042817034.1  insulin-degrading enzyme isoform X7

    UniProtKB/TrEMBL
    A0A8C9JPL5
    Conserved Domains (1) summary
    COG1025
    Location:52 → 958
    Ptr; Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, protein turnover, chaperones]

  5. XM_042961092.1 → XP_042817026.1  insulin-degrading enzyme isoform X1

    UniProtKB/TrEMBL
    A0A8C9JPL5
    Conserved Domains (1) summary
    COG1025
    Location:52 → 958
    Ptr; Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, protein turnover, chaperones]

  6. XM_042961093.1 → XP_042817027.1  insulin-degrading enzyme isoform X2

    UniProtKB/TrEMBL
    A0A8C9JPL5
    Conserved Domains (1) summary
    COG1025
    Location:36 → 942
    Ptr; Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, protein turnover, chaperones]

  7. XM_042961094.1 → XP_042817028.1  insulin-degrading enzyme isoform X3

    UniProtKB/TrEMBL
    A0A8C9JPL5
    Conserved Domains (1) summary
    COG1025
    Location:21 → 927
    Ptr; Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, protein turnover, chaperones]

  8. XM_042961098.1 → XP_042817032.1  insulin-degrading enzyme isoform X5

    UniProtKB/TrEMBL
    A0A8C9JPL5
    Conserved Domains (1) summary
    COG1025
    Location:2 → 764
    Ptr; Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, protein turnover, chaperones]

  9. XM_042961099.1 → XP_042817033.1  insulin-degrading enzyme isoform X6

    Conserved Domains (1) summary
    COG1025
    Location:37 → 733
    Ptr; Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, protein turnover, chaperones]
Nucleotide Protein
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