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ARHGEF11 Rho guanine nucleotide exchange factor 11 [ Panthera tigris (tiger) ]

Gene ID: 102962367, updated on 10-Mar-2024

Summary

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Gene symbol
ARHGEF11
Gene description
Rho guanine nucleotide exchange factor 11
Gene type
protein coding
RefSeq status
MODEL
Organism
Panthera tigris
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Pantherinae; Panthera
Orthologs
human mouse all
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Genomic context

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See ARHGEF11 in Genome Data Viewer
Location:
chromosome: F3
Exon count:
42
Annotation release Status Assembly Chr Location
102 current P.tigris_Pti1_mat1.1 (GCF_018350195.1) F3 NC_056678.1 (67016714..67103852)

Chromosome F3 - NC_056678.1Genomic Context describing neighboring genes Neighboring gene ETS variant transcription factor 3 Neighboring gene ETS translocation variant 3-like protein Neighboring gene leucine rich repeat containing 71 Neighboring gene platelet endothelial aggregation receptor 1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_056678.1 Chromosome F3 Reference P.tigris_Pti1_mat1.1 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables G protein-coupled receptor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in Rho protein signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
rho guanine nucleotide exchange factor 11
Names
Rho guanine nucleotide exchange factor (GEF) 11

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Panthera tigris Annotation Release 102 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference P.tigris_Pti1_mat1.1 Primary Assembly

Genomic

  1. NC_056678.1 Reference P.tigris_Pti1_mat1.1 Primary Assembly

    Range
    67016714..67103852
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_042977017.1 → XP_042832951.1  rho guanine nucleotide exchange factor 11 isoform X1

    Conserved Domains (4) summary
    cd08753
    Location:337 → 481
    RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein
    cd00160
    Location:783 → 969
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00992
    Location:53 → 125
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13391
    Location:987 → 1129
    PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain

  2. XM_042977024.1 → XP_042832958.1  rho guanine nucleotide exchange factor 11 isoform X8

    Conserved Domains (5) summary
    cd08753
    Location:337 → 481
    RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein
    PHA03307
    Location:1193 → 1506
    PHA03307; transcriptional regulator ICP4; Provisional
    cd00160
    Location:783 → 969
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00992
    Location:53 → 125
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13391
    Location:987 → 1129
    PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain

  3. XM_042977018.1 → XP_042832952.1  rho guanine nucleotide exchange factor 11 isoform X2

    Conserved Domains (4) summary
    cd08753
    Location:337 → 481
    RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein
    cd00160
    Location:783 → 969
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00992
    Location:53 → 125
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13391
    Location:987 → 1129
    PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain

  4. XM_042977026.1 → XP_042832960.1  rho guanine nucleotide exchange factor 11 isoform X10

    Conserved Domains (4) summary
    cd08753
    Location:337 → 481
    RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein
    cd00160
    Location:783 → 969
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00992
    Location:53 → 125
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13391
    Location:987 → 1129
    PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain

  5. XM_042977022.1 → XP_042832956.1  rho guanine nucleotide exchange factor 11 isoform X6

    Conserved Domains (4) summary
    cd08753
    Location:337 → 481
    RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein
    cd00160
    Location:773 → 959
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00992
    Location:53 → 125
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13391
    Location:977 → 1119
    PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain

  6. XM_042977019.1 → XP_042832953.1  rho guanine nucleotide exchange factor 11 isoform X3

    Conserved Domains (4) summary
    cd08753
    Location:337 → 481
    RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein
    cd00160
    Location:782 → 968
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00992
    Location:53 → 125
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13391
    Location:986 → 1128
    PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain

  7. XM_042977020.1 → XP_042832954.1  rho guanine nucleotide exchange factor 11 isoform X4

    Conserved Domains (4) summary
    cd08753
    Location:337 → 481
    RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein
    cd00160
    Location:782 → 968
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00992
    Location:53 → 125
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13391
    Location:986 → 1128
    PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain

  8. XM_042977023.1 → XP_042832957.1  rho guanine nucleotide exchange factor 11 isoform X7

    Conserved Domains (4) summary
    cd08753
    Location:337 → 481
    RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein
    cd00160
    Location:772 → 958
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00992
    Location:53 → 125
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13391
    Location:976 → 1118
    PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain

  9. XM_042977025.1 → XP_042832959.1  rho guanine nucleotide exchange factor 11 isoform X9

    Conserved Domains (4) summary
    smart00325
    Location:753 → 937
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd00992
    Location:53 → 125
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13391
    Location:954 → 1096
    PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
    cl02565
    Location:337 → 448
    RGS; Regulator of G protein signaling (RGS) domain superfamily

  10. XM_042977021.1 → XP_042832955.1  rho guanine nucleotide exchange factor 11 isoform X5

    Conserved Domains (4) summary
    cd08753
    Location:332 → 476
    RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein
    cd00160
    Location:778 → 964
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00992
    Location:48 → 120
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13391
    Location:982 → 1124
    PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
Nucleotide Protein
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