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SHMT1 serine hydroxymethyltransferase 1 [ Panthera tigris (tiger) ]

Gene ID: 102955890, updated on 10-Mar-2024

Summary

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Gene symbol
SHMT1
Gene description
serine hydroxymethyltransferase 1
See related
Ensembl:ENSPTIG00000005454
Gene type
protein coding
RefSeq status
MODEL
Organism
Panthera tigris
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Pantherinae; Panthera
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: E1
Exon count:
12
Annotation release Status Assembly Chr Location
102 current P.tigris_Pti1_mat1.1 (GCF_018350195.1) E1 NC_056673.1 (11007196..11033343)

Chromosome E1 - NC_056673.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 5 member 10 Neighboring gene family with sequence similarity 83 member G Neighboring gene phosphoribosyl pyrophosphate synthetase associated protein 2 Neighboring gene SMCR8-C9orf72 complex subunit Neighboring gene DNA topoisomerase III alpha

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_056673.1 Chromosome E1 Reference P.tigris_Pti1_mat1.1 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables cobalt ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables glycine hydroxymethyltransferase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables mRNA 5'-UTR binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables mRNA regulatory element binding translation repressor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables pyridoxal phosphate binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables serine binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in L-serine catabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cellular response to leukemia inhibitory factor IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in folic acid metabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in glycine biosynthetic process from serine IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein homotetramerization IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in purine nucleobase biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in tetrahydrofolate interconversion IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
serine hydroxymethyltransferase, cytosolic

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Panthera tigris Annotation Release 102 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference P.tigris_Pti1_mat1.1 Primary Assembly

Genomic

  1. NC_056673.1 Reference P.tigris_Pti1_mat1.1 Primary Assembly

    Range
    11007196..11033343
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_007080767.2 → XP_007080829.1  serine hydroxymethyltransferase, cytosolic

    UniProtKB/TrEMBL
    A0A8C9J7P7, A0A8C9J9T8
    Related
    ENSPTIP00000002466.1
    Conserved Domains (1) summary
    PLN03226
    Location:24 → 481
    PLN03226; serine hydroxymethyltransferase; Provisional

  2. XM_042966604.1 → XP_042822538.1  serine hydroxymethyltransferase, cytosolic

    UniProtKB/TrEMBL
    A0A8C9J7P7, A0A8C9J9T8
    Conserved Domains (1) summary
    PLN03226
    Location:24 → 481
    PLN03226; serine hydroxymethyltransferase; Provisional
Nucleotide Protein
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