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ARHGEF11 Rho guanine nucleotide exchange factor 11 [ Tupaia chinensis (Chinese tree shrew) ]

Gene ID: 102475544, updated on 10-Mar-2024

Summary

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Gene symbol
ARHGEF11
Gene description
Rho guanine nucleotide exchange factor 11
Locus tag
TREES_T100016109
Gene type
protein coding
RefSeq status
MODEL
Organism
Tupaia chinensis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Scandentia; Tupaiidae; Tupaia
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: Un
Exon count:
45
Annotation release Status Assembly Chr Location
102 current TupChi_1.0 (GCF_000334495.1) Unplaced Scaffold NW_006159943.1 (1465514..1596246, complement)

NW_006159943.1Genomic Context describing neighboring genes Neighboring gene platelet endothelial aggregation receptor 1 Neighboring gene leucine rich repeat containing 71 Neighboring gene ETS variant transcription factor 3 like Neighboring gene ETS variant transcription factor 3

Genomic regions, transcripts, and products

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Genomic Sequence:
NW_006159943 Unplaced Scaffold Reference TupChi_1.0

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Sodium taurocholate cotransporting polypeptide is a functional receptor for human hepatitis B and D virus. Yan H, et al. Elife, 2012 Nov 13. PMID 23150796, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables G protein-coupled receptor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in Rho protein signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
rho guanine nucleotide exchange factor 11

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Tupaia chinensis Annotation Release 102 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference TupChi_1.0

Genomic

  1. NW_006159943.1 Reference TupChi_1.0

    Range
    1465514..1596246 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006155215.3 → XP_006155277.1  rho guanine nucleotide exchange factor 11 isoform X5

    UniProtKB/TrEMBL
    L9KET3
    Conserved Domains (7) summary
    cd08753
    Location:330 → 474
    RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein
    COG0265
    Location:61 → 139
    DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]
    cd00992
    Location:46 → 120
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam05549
    Location:1405 → 1439
    Allexi_40kDa; Allexivirus 40kDa protein
    cd13391
    Location:979 → 1121
    PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
    pfam00169
    Location:1039 → 1119
    PH; PH domain
    pfam00621
    Location:778 → 962
    RhoGEF; RhoGEF domain

  2. XM_006155213.3 → XP_006155275.1  rho guanine nucleotide exchange factor 11 isoform X4

    UniProtKB/TrEMBL
    L9KET3
    Conserved Domains (7) summary
    cd08753
    Location:341 → 485
    RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein
    COG0265
    Location:72 → 150
    DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]
    cd00992
    Location:57 → 131
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam05549
    Location:1416 → 1450
    Allexi_40kDa; Allexivirus 40kDa protein
    cd13391
    Location:990 → 1132
    PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
    pfam00169
    Location:1050 → 1130
    PH; PH domain
    pfam00621
    Location:789 → 973
    RhoGEF; RhoGEF domain

  3. XM_006155212.3 → XP_006155274.1  rho guanine nucleotide exchange factor 11 isoform X2

    UniProtKB/TrEMBL
    L9KET3
    Conserved Domains (7) summary
    cd08753
    Location:346 → 490
    RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein
    COG0265
    Location:77 → 155
    DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]
    cd00992
    Location:62 → 136
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam05549
    Location:1421 → 1455
    Allexi_40kDa; Allexivirus 40kDa protein
    cd13391
    Location:995 → 1137
    PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
    pfam00169
    Location:1055 → 1135
    PH; PH domain
    pfam00621
    Location:794 → 978
    RhoGEF; RhoGEF domain

  4. XM_014590407.2 → XP_014445893.1  rho guanine nucleotide exchange factor 11 isoform X6

    UniProtKB/TrEMBL
    L9KET3
    Conserved Domains (7) summary
    cd08753
    Location:356 → 500
    RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein
    COG0265
    Location:87 → 165
    DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]
    cd00992
    Location:72 → 146
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam05549
    Location:1399 → 1433
    Allexi_40kDa; Allexivirus 40kDa protein
    cd13391
    Location:1005 → 1147
    PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
    pfam00169
    Location:1065 → 1145
    PH; PH domain
    pfam00621
    Location:804 → 988
    RhoGEF; RhoGEF domain

  5. XM_014590406.2 → XP_014445892.1  rho guanine nucleotide exchange factor 11 isoform X3

    UniProtKB/TrEMBL
    L9KET3
    Conserved Domains (7) summary
    cd08753
    Location:356 → 500
    RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein
    COG0265
    Location:87 → 165
    DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]
    cd00992
    Location:72 → 146
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam05549
    Location:1421 → 1455
    Allexi_40kDa; Allexivirus 40kDa protein
    cd13391
    Location:995 → 1137
    PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
    pfam00169
    Location:1055 → 1135
    PH; PH domain
    pfam00621
    Location:794 → 978
    RhoGEF; RhoGEF domain

  6. XM_014590409.2 → XP_014445895.1  rho guanine nucleotide exchange factor 11 isoform X7

    UniProtKB/TrEMBL
    L9KET3
    Conserved Domains (7) summary
    cd08753
    Location:316 → 460
    RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein
    COG0265
    Location:87 → 165
    DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]
    cd00992
    Location:72 → 146
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam05549
    Location:1391 → 1425
    Allexi_40kDa; Allexivirus 40kDa protein
    cd13391
    Location:965 → 1107
    PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
    pfam00169
    Location:1025 → 1105
    PH; PH domain
    pfam00621
    Location:764 → 948
    RhoGEF; RhoGEF domain

  7. XM_006155216.3 → XP_006155278.2  rho guanine nucleotide exchange factor 11 isoform X1

    UniProtKB/TrEMBL
    L9KET3
    Conserved Domains (7) summary
    cd08753
    Location:356 → 500
    RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein
    COG0265
    Location:87 → 165
    DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]
    cd00992
    Location:72 → 146
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam05549
    Location:1431 → 1465
    Allexi_40kDa; Allexivirus 40kDa protein
    cd13391
    Location:1005 → 1147
    PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
    pfam00169
    Location:1065 → 1145
    PH; PH domain
    pfam00621
    Location:804 → 988
    RhoGEF; RhoGEF domain

  8. XM_014590410.2 → XP_014445896.2  rho guanine nucleotide exchange factor 11 isoform X8

    UniProtKB/TrEMBL
    L9KET3

  9. XM_014590411.2 → XP_014445897.1  rho guanine nucleotide exchange factor 11 isoform X9

    UniProtKB/TrEMBL
    L9KET3
    Conserved Domains (6) summary
    cd08753
    Location:356 → 500
    RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein
    COG0265
    Location:87 → 165
    DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]
    cd00992
    Location:72 → 146
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13391
    Location:1005 → 1147
    PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
    pfam00169
    Location:1065 → 1145
    PH; PH domain
    pfam00621
    Location:804 → 988
    RhoGEF; RhoGEF domain
Nucleotide Protein
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