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ITSN2 intersectin 2 [ Myotis lucifugus (little brown bat) ]

Gene ID: 102418252, updated on 30-Mar-2024

Summary

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Gene symbol
ITSN2
Gene description
intersectin 2
See related
Ensembl:ENSMLUG00000002494
Gene type
protein coding
RefSeq status
MODEL
Organism
Myotis lucifugus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Chiroptera; Yangochiroptera; Vespertilionidae; Myotis
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: Un
Exon count:
44
Annotation release Status Assembly Chr Location
102 current Myoluc2.0 (GCF_000147115.1) Unplaced Scaffold NW_005871142.1 (573417..672990)

NW_005871142.1Genomic Context describing neighboring genes Neighboring gene nuclear receptor coactivator 1 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene mitochondrial import receptor subunit TOM5 homolog pseudogene Neighboring gene protein FAM228B Neighboring gene U6 spliceosomal RNA Neighboring gene tumor protein p53 inducible protein 3

Genomic regions, transcripts, and products

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Genomic Sequence:
NW_005871142 Unplaced Scaffold Reference Myoluc2.0

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables molecular adaptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in clathrin-dependent synaptic vesicle endocytosis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in endosomal transport IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of Rho protein signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in clathrin-coated pit IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in intracellular vesicle IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in presynaptic membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
intersectin-2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Myotis lucifugus Annotation Release 102 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Myoluc2.0

Genomic

  1. NW_005871142.1 Reference Myoluc2.0

    Range
    573417..672990
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_023756438.1 → XP_023612206.1  intersectin-2 isoform X1

    UniProtKB/TrEMBL
    G1NY23
    Conserved Domains (12) summary
    cd08375
    Location:1541 → 1675
    C2_Intersectin; C2 domain present in Intersectin
    smart00027
    Location:15 → 107
    EH; Eps15 homology domain
    cd11988
    Location:748 → 804
    SH3_Intersectin2_1; First Src homology 3 domain (or SH3A) of Intersectin-2
    cd11990
    Location:888 → 939
    SH3_Intersectin2_2; Second Src homology 3 domain (or SH3B) of Intersectin-2
    cd11992
    Location:971 → 1022
    SH3_Intersectin2_3; Third Src homology 3 domain (or SH3C) of Intersectin-2
    cd11994
    Location:1043 → 1101
    SH3_Intersectin2_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-2
    cd11996
    Location:1116 → 1169
    SH3_Intersectin2_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-2
    cd00160
    Location:1196 → 1379
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    pfam15279
    Location:90 → 203
    SOBP; Sine oculis-binding protein
    pfam16617
    Location:806 → 888
    INTAP; Intersectin and clathrin adaptor AP2 binding region
    pfam16652
    Location:1398 → 1540
    PH_13; Pleckstrin homology domain
    cl25732
    Location:354 → 699
    SMC_N; RecF/RecN/SMC N terminal domain

  2. XM_014458353.2 → XP_014313839.1  intersectin-2 isoform X2

    UniProtKB/TrEMBL
    G1NY23
    Related
    ENSMLUP00000002296.2, ENSMLUT00000002526.2
    Conserved Domains (16) summary
    cd08375
    Location:1513 → 1647
    C2_Intersectin; C2 domain present in Intersectin
    smart00027
    Location:15 → 107
    EH; Eps15 homology domain
    cd11988
    Location:720 → 776
    SH3_Intersectin2_1; First Src homology 3 domain (or SH3A) of Intersectin-2
    cd11990
    Location:860 → 911
    SH3_Intersectin2_2; Second Src homology 3 domain (or SH3B) of Intersectin-2
    cd11992
    Location:943 → 994
    SH3_Intersectin2_3; Third Src homology 3 domain (or SH3C) of Intersectin-2
    cd11994
    Location:1015 → 1073
    SH3_Intersectin2_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-2
    cd11996
    Location:1088 → 1141
    SH3_Intersectin2_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-2
    cd00052
    Location:249 → 315
    EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
    cd13264
    Location:1378 → 1510
    PH_ITSN; Intersectin Pleckstrin homology (PH) domain
    pfam00169
    Location:1393 → 1502
    PH; PH domain
    pfam00621
    Location:1172 → 1352
    RhoGEF; RhoGEF domain
    pfam07926
    Location:598 → 699
    TPR_MLP1_2; TPR/MLP1/MLP2-like protein
    pfam13499
    Location:250 → 307
    EF-hand_7; EF-hand domain pair
    pfam16617
    Location:778 → 860
    INTAP; Intersectin and clathrin adaptor AP2 binding region
    cd16269
    Location:466 → 477
    GBP_C; coiled coil [structural motif]
    cl20817
    Location:380 → 492
    GBP_C; Guanylate-binding protein, C-terminal domain

  3. XM_023756445.1 → XP_023612213.1  intersectin-2 isoform X9

    Conserved Domains (9) summary
    smart00027
    Location:15 → 107
    EH; Eps15 homology domain
    cd11988
    Location:720 → 776
    SH3_Intersectin2_1; First Src homology 3 domain (or SH3A) of Intersectin-2
    cd11990
    Location:860 → 911
    SH3_Intersectin2_2; Second Src homology 3 domain (or SH3B) of Intersectin-2
    cd11992
    Location:943 → 994
    SH3_Intersectin2_3; Third Src homology 3 domain (or SH3C) of Intersectin-2
    cd11994
    Location:1015 → 1073
    SH3_Intersectin2_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-2
    cd11996
    Location:1088 → 1141
    SH3_Intersectin2_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-2
    pfam15279
    Location:90 → 203
    SOBP; Sine oculis-binding protein
    pfam16617
    Location:778 → 860
    INTAP; Intersectin and clathrin adaptor AP2 binding region
    cl25732
    Location:354 → 699
    SMC_N; RecF/RecN/SMC N terminal domain

  4. XM_023756439.1 → XP_023612207.1  intersectin-2 isoform X3

    UniProtKB/TrEMBL
    G1NY23
    Conserved Domains (11) summary
    smart00027
    Location:15 → 107
    EH; Eps15 homology domain
    cd11988
    Location:748 → 804
    SH3_Intersectin2_1; First Src homology 3 domain (or SH3A) of Intersectin-2
    cd11990
    Location:888 → 939
    SH3_Intersectin2_2; Second Src homology 3 domain (or SH3B) of Intersectin-2
    cd11992
    Location:971 → 1022
    SH3_Intersectin2_3; Third Src homology 3 domain (or SH3C) of Intersectin-2
    cd11994
    Location:1043 → 1101
    SH3_Intersectin2_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-2
    cd11996
    Location:1116 → 1169
    SH3_Intersectin2_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-2
    cd00160
    Location:1196 → 1379
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    pfam15279
    Location:90 → 203
    SOBP; Sine oculis-binding protein
    pfam16617
    Location:806 → 888
    INTAP; Intersectin and clathrin adaptor AP2 binding region
    pfam16652
    Location:1398 → 1520
    PH_13; Pleckstrin homology domain
    cl25732
    Location:354 → 699
    SMC_N; RecF/RecN/SMC N terminal domain

  5. XM_023756440.1 → XP_023612208.1  intersectin-2 isoform X4

    UniProtKB/TrEMBL
    G1NY23
    Conserved Domains (11) summary
    smart00027
    Location:15 → 107
    EH; Eps15 homology domain
    cd11988
    Location:748 → 804
    SH3_Intersectin2_1; First Src homology 3 domain (or SH3A) of Intersectin-2
    cd11990
    Location:888 → 939
    SH3_Intersectin2_2; Second Src homology 3 domain (or SH3B) of Intersectin-2
    cd11992
    Location:971 → 1022
    SH3_Intersectin2_3; Third Src homology 3 domain (or SH3C) of Intersectin-2
    cd11994
    Location:1043 → 1101
    SH3_Intersectin2_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-2
    cd11996
    Location:1116 → 1169
    SH3_Intersectin2_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-2
    cd00160
    Location:1196 → 1379
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    pfam15279
    Location:90 → 203
    SOBP; Sine oculis-binding protein
    pfam16617
    Location:806 → 888
    INTAP; Intersectin and clathrin adaptor AP2 binding region
    cl17171
    Location:1398 → 1476
    PH-like; Pleckstrin homology-like domain
    cl25732
    Location:354 → 699
    SMC_N; RecF/RecN/SMC N terminal domain

  6. XM_023756444.1 → XP_023612212.1  intersectin-2 isoform X8

    Conserved Domains (9) summary
    smart00027
    Location:15 → 107
    EH; Eps15 homology domain
    cd11988
    Location:748 → 804
    SH3_Intersectin2_1; First Src homology 3 domain (or SH3A) of Intersectin-2
    cd11990
    Location:888 → 939
    SH3_Intersectin2_2; Second Src homology 3 domain (or SH3B) of Intersectin-2
    cd11992
    Location:971 → 1022
    SH3_Intersectin2_3; Third Src homology 3 domain (or SH3C) of Intersectin-2
    cd11994
    Location:1043 → 1101
    SH3_Intersectin2_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-2
    cd11996
    Location:1116 → 1169
    SH3_Intersectin2_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-2
    pfam15279
    Location:90 → 203
    SOBP; Sine oculis-binding protein
    pfam16617
    Location:806 → 888
    INTAP; Intersectin and clathrin adaptor AP2 binding region
    cl25732
    Location:354 → 699
    SMC_N; RecF/RecN/SMC N terminal domain

  7. XM_023756442.1 → XP_023612210.1  intersectin-2 isoform X6

    Conserved Domains (9) summary
    smart00027
    Location:15 → 107
    EH; Eps15 homology domain
    cd11988
    Location:748 → 804
    SH3_Intersectin2_1; First Src homology 3 domain (or SH3A) of Intersectin-2
    cd11990
    Location:888 → 939
    SH3_Intersectin2_2; Second Src homology 3 domain (or SH3B) of Intersectin-2
    cd11992
    Location:971 → 1022
    SH3_Intersectin2_3; Third Src homology 3 domain (or SH3C) of Intersectin-2
    cd11994
    Location:1043 → 1101
    SH3_Intersectin2_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-2
    cd11996
    Location:1116 → 1169
    SH3_Intersectin2_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-2
    pfam15279
    Location:90 → 203
    SOBP; Sine oculis-binding protein
    pfam16617
    Location:806 → 888
    INTAP; Intersectin and clathrin adaptor AP2 binding region
    cl25732
    Location:354 → 699
    SMC_N; RecF/RecN/SMC N terminal domain

  8. XM_023756443.1 → XP_023612211.1  intersectin-2 isoform X7

    Conserved Domains (9) summary
    smart00027
    Location:15 → 107
    EH; Eps15 homology domain
    cd11988
    Location:748 → 804
    SH3_Intersectin2_1; First Src homology 3 domain (or SH3A) of Intersectin-2
    cd11990
    Location:888 → 939
    SH3_Intersectin2_2; Second Src homology 3 domain (or SH3B) of Intersectin-2
    cd11992
    Location:971 → 1022
    SH3_Intersectin2_3; Third Src homology 3 domain (or SH3C) of Intersectin-2
    cd11994
    Location:1043 → 1101
    SH3_Intersectin2_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-2
    cd11996
    Location:1116 → 1169
    SH3_Intersectin2_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-2
    pfam15279
    Location:90 → 203
    SOBP; Sine oculis-binding protein
    pfam16617
    Location:806 → 888
    INTAP; Intersectin and clathrin adaptor AP2 binding region
    cl25732
    Location:354 → 699
    SMC_N; RecF/RecN/SMC N terminal domain

  9. XM_023756441.1 → XP_023612209.1  intersectin-2 isoform X5

    UniProtKB/TrEMBL
    G1NY23
    Conserved Domains (11) summary
    cd08375
    Location:1282 → 1416
    C2_Intersectin; C2 domain present in Intersectin
    cd11988
    Location:489 → 545
    SH3_Intersectin2_1; First Src homology 3 domain (or SH3A) of Intersectin-2
    cd11990
    Location:629 → 680
    SH3_Intersectin2_2; Second Src homology 3 domain (or SH3B) of Intersectin-2
    cd11992
    Location:712 → 763
    SH3_Intersectin2_3; Third Src homology 3 domain (or SH3C) of Intersectin-2
    cd11994
    Location:784 → 842
    SH3_Intersectin2_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-2
    cd11996
    Location:857 → 910
    SH3_Intersectin2_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-2
    cd00160
    Location:937 → 1120
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    pfam16617
    Location:547 → 629
    INTAP; Intersectin and clathrin adaptor AP2 binding region
    pfam16652
    Location:1139 → 1281
    PH_13; Pleckstrin homology domain
    cl25732
    Location:119 → 440
    SMC_N; RecF/RecN/SMC N terminal domain
    cl27812
    Location:1 → 58
    EF-hand_4; Cytoskeletal-regulatory complex EF hand

RNA

  1. XR_002830015.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version

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