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ITSN2 intersectin 2 [ Homo sapiens (human) ]

Gene ID: 50618, updated on 24-Nov-2020

Summary

Official Symbol
ITSN2provided by HGNC
Official Full Name
intersectin 2provided by HGNC
Primary source
HGNC:HGNC:6184
See related
Ensembl:ENSG00000198399 MIM:604464
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SWA; SWAP; SH3D1B; SH3P18; PRO2015
Summary
This gene encodes a cytoplasmic protein which contains SH3 domains. This protein is a member of a family of proteins involved in clathrin-mediated endocytosis. Intersectin 2 is thought to regulate the formation of clathrin-coated vesicles and also may function in the induction of T cell antigen receptor (TCR) endocytosis. [provided by RefSeq, Jan 2017]
Expression
Ubiquitous expression in thyroid (RPKM 16.9), lymph node (RPKM 13.9) and 25 other tissues See more
Orthologs

Genomic context

See ITSN2 in Genome Data Viewer
Location:
2p23.3
Exon count:
45
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (24202864..24360538, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (24425733..24583647, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 228 member B Neighboring gene uncharacterized LOC105374328 Neighboring gene family with sequence similarity 228 member A Neighboring gene ribosomal protein L36a pseudogene 13 Neighboring gene high mobility group nucleosomal binding domain 2 pseudogene 20 Neighboring gene Sharpr-MPRA regulatory region 9937 Neighboring gene uncharacterized LOC105374329 Neighboring gene CRISPRi-validated cis-regulatory element chr2.904

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome-wide association study identifies multiple susceptibility loci for diffuse large B cell lymphoma.
GeneReviews: Not available
Genome-wide pharmacogenomic study of neurocognition as an indicator of antipsychotic treatment response in schizophrenia.
GeneReviews: Not available

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of intersectin 2 (ITSN2; SH3P18) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA1256

Gene Ontology Provided by GOA

Function Evidence Code Pubs
calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
 
molecular adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
clathrin-dependent synaptic vesicle endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endosomal transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of dendrite extension IDA
Inferred from Direct Assay
more info
PubMed 
viral process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
centrosome IDA
Inferred from Direct Assay
more info
PubMed 
clathrin-coated pit IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
extracellular exosome HDA PubMed 
intracellular vesicle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
presynapse IEA
Inferred from Electronic Annotation
more info
 
presynaptic membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
intersectin-2
Names
SH3 domain-containing protein 1B
SH3P18-like WASP-associated protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029516.1 RefSeqGene

    Range
    4993..162665
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001348181.2NP_001335110.1  intersectin-2 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC008073, AC009228
    Conserved Domains (12) summary
    cd08375
    Location:15411675
    C2_Intersectin; C2 domain present in Intersectin
    smart00027
    Location:193
    EH; Eps15 homology domain
    cd11988
    Location:745801
    SH3_Intersectin2_1; First Src homology 3 domain (or SH3A) of Intersectin-2
    cd11990
    Location:888939
    SH3_Intersectin2_2; Second Src homology 3 domain (or SH3B) of Intersectin-2
    cd11992
    Location:9711022
    SH3_Intersectin2_3; Third Src homology 3 domain (or SH3C) of Intersectin-2
    cd11994
    Location:10431101
    SH3_Intersectin2_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-2
    cd11996
    Location:11161169
    SH3_Intersectin2_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-2
    smart00325
    Location:12001380
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    pfam15279
    Location:76168
    SOBP; Sine oculis-binding protein
    pfam16617
    Location:801888
    INTAP; Intersectin and clathrin adaptor AP2 binding region
    pfam16652
    Location:13981540
    PH_13; Pleckstrin homology domain
    cl26511
    Location:332742
    Neuromodulin_N; Gap junction protein N-terminal region
  2. NM_001348182.2NP_001335111.1  intersectin-2 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC008073, AC009228
    Conserved Domains (12) summary
    cd08375
    Location:15151649
    C2_Intersectin; C2 domain present in Intersectin
    smart00027
    Location:15107
    EH; Eps15 homology domain
    cd11988
    Location:719775
    SH3_Intersectin2_1; First Src homology 3 domain (or SH3A) of Intersectin-2
    cd11990
    Location:862913
    SH3_Intersectin2_2; Second Src homology 3 domain (or SH3B) of Intersectin-2
    cd11992
    Location:945996
    SH3_Intersectin2_3; Third Src homology 3 domain (or SH3C) of Intersectin-2
    cd11994
    Location:10171075
    SH3_Intersectin2_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-2
    cd11996
    Location:10901143
    SH3_Intersectin2_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-2
    smart00325
    Location:11741354
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    pfam16617
    Location:775862
    INTAP; Intersectin and clathrin adaptor AP2 binding region
    pfam16652
    Location:13721514
    PH_13; Pleckstrin homology domain
    cl25732
    Location:377719
    SMC_N; RecF/RecN/SMC N terminal domain
    cl27427
    Location:126200
    AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]
  3. NM_001348183.2NP_001335112.1  intersectin-2 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC009228
    Conserved Domains (9) summary
    smart00027
    Location:15107
    EH; Eps15 homology domain
    cd11988
    Location:732788
    SH3_Intersectin2_1; First Src homology 3 domain (or SH3A) of Intersectin-2
    cd11990
    Location:875926
    SH3_Intersectin2_2; Second Src homology 3 domain (or SH3B) of Intersectin-2
    cd11992
    Location:9581009
    SH3_Intersectin2_3; Third Src homology 3 domain (or SH3C) of Intersectin-2
    cd11994
    Location:10301088
    SH3_Intersectin2_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-2
    cd11996
    Location:11031156
    SH3_Intersectin2_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-2
    pfam15279
    Location:90182
    SOBP; Sine oculis-binding protein
    pfam16617
    Location:788875
    INTAP; Intersectin and clathrin adaptor AP2 binding region
    cl25732
    Location:377727
    SMC_N; RecF/RecN/SMC N terminal domain
  4. NM_001348184.2NP_001335113.1  intersectin-2 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AC009228
    Conserved Domains (9) summary
    smart00027
    Location:193
    EH; Eps15 homology domain
    cd11988
    Location:718774
    SH3_Intersectin2_1; First Src homology 3 domain (or SH3A) of Intersectin-2
    cd11990
    Location:861912
    SH3_Intersectin2_2; Second Src homology 3 domain (or SH3B) of Intersectin-2
    cd11992
    Location:944995
    SH3_Intersectin2_3; Third Src homology 3 domain (or SH3C) of Intersectin-2
    cd11994
    Location:10161074
    SH3_Intersectin2_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-2
    cd11996
    Location:10891142
    SH3_Intersectin2_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-2
    pfam15279
    Location:76168
    SOBP; Sine oculis-binding protein
    pfam16617
    Location:774861
    INTAP; Intersectin and clathrin adaptor AP2 binding region
    cl25732
    Location:363713
    SMC_N; RecF/RecN/SMC N terminal domain
  5. NM_001348185.2NP_001335114.1  intersectin-2 isoform 8

    Status: REVIEWED

    Source sequence(s)
    AC009228
    Conserved Domains (9) summary
    smart00027
    Location:15107
    EH; Eps15 homology domain
    cd11988
    Location:746802
    SH3_Intersectin2_1; First Src homology 3 domain (or SH3A) of Intersectin-2
    cd11990
    Location:889940
    SH3_Intersectin2_2; Second Src homology 3 domain (or SH3B) of Intersectin-2
    cd11992
    Location:9721023
    SH3_Intersectin2_3; Third Src homology 3 domain (or SH3C) of Intersectin-2
    cd11994
    Location:10441102
    SH3_Intersectin2_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-2
    cd11996
    Location:11171170
    SH3_Intersectin2_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-2
    pfam16617
    Location:802889
    INTAP; Intersectin and clathrin adaptor AP2 binding region
    cl26511
    Location:346743
    Neuromodulin_N; Gap junction protein N-terminal region
    cl27427
    Location:126200
    AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]
  6. NM_001348186.2NP_001335115.1  intersectin-2 isoform 9

    Status: REVIEWED

    Source sequence(s)
    AC009228
    Conserved Domains (9) summary
    smart00027
    Location:15107
    EH; Eps15 homology domain
    cd11988
    Location:719775
    SH3_Intersectin2_1; First Src homology 3 domain (or SH3A) of Intersectin-2
    cd11990
    Location:862913
    SH3_Intersectin2_2; Second Src homology 3 domain (or SH3B) of Intersectin-2
    cd11992
    Location:945996
    SH3_Intersectin2_3; Third Src homology 3 domain (or SH3C) of Intersectin-2
    cd11994
    Location:10171075
    SH3_Intersectin2_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-2
    cd11996
    Location:10901143
    SH3_Intersectin2_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-2
    pfam16617
    Location:775862
    INTAP; Intersectin and clathrin adaptor AP2 binding region
    cl25732
    Location:377719
    SMC_N; RecF/RecN/SMC N terminal domain
    cl27427
    Location:126200
    AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]
  7. NM_006277.3NP_006268.2  intersectin-2 isoform 1

    See identical proteins and their annotated locations for NP_006268.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1), also known as ITSN2-L, encodes the longest isoform (1).
    Source sequence(s)
    AC008073, AC009228, AF182198, BC146779, DA382952
    Consensus CDS
    CCDS1710.2
    UniProtKB/Swiss-Prot
    Q9NZM3
    UniProtKB/TrEMBL
    A6H8W8
    Related
    ENSP00000347244.4, ENST00000355123.8
    Conserved Domains (12) summary
    cd08375
    Location:15551689
    C2_Intersectin; C2 domain present in Intersectin
    smart00027
    Location:15107
    EH; Eps15 homology domain
    cd11988
    Location:759815
    SH3_Intersectin2_1; First Src homology 3 domain (or SH3A) of Intersectin-2
    cd11990
    Location:902953
    SH3_Intersectin2_2; Second Src homology 3 domain (or SH3B) of Intersectin-2
    cd11992
    Location:9851036
    SH3_Intersectin2_3; Third Src homology 3 domain (or SH3C) of Intersectin-2
    cd11994
    Location:10571115
    SH3_Intersectin2_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-2
    cd11996
    Location:11301183
    SH3_Intersectin2_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-2
    smart00325
    Location:12141394
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    pfam15279
    Location:90182
    SOBP; Sine oculis-binding protein
    pfam16617
    Location:815902
    INTAP; Intersectin and clathrin adaptor AP2 binding region
    pfam16652
    Location:14121554
    PH_13; Pleckstrin homology domain
    cl26511
    Location:346756
    Neuromodulin_N; Gap junction protein N-terminal region
  8. NM_019595.4NP_062541.3  intersectin-2 isoform 3

    See identical proteins and their annotated locations for NP_062541.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon, compared to variant 1. This results in a shorter protein (isoform 3) that lacks an internal segment, compared to isoform 1.
    Source sequence(s)
    AC008073, AC009228, AF182198, AF182199, BC146779, DA382952
    Consensus CDS
    CCDS1711.2
    UniProtKB/Swiss-Prot
    Q9NZM3
    UniProtKB/TrEMBL
    A6H8W8
    Related
    ENSP00000354561.2, ENST00000361999.7
    Conserved Domains (12) summary
    cd08375
    Location:15281662
    C2_Intersectin; C2 domain present in Intersectin
    smart00027
    Location:15107
    EH; Eps15 homology domain
    cd11988
    Location:732788
    SH3_Intersectin2_1; First Src homology 3 domain (or SH3A) of Intersectin-2
    cd11990
    Location:875926
    SH3_Intersectin2_2; Second Src homology 3 domain (or SH3B) of Intersectin-2
    cd11992
    Location:9581009
    SH3_Intersectin2_3; Third Src homology 3 domain (or SH3C) of Intersectin-2
    cd11994
    Location:10301088
    SH3_Intersectin2_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-2
    cd11996
    Location:11031156
    SH3_Intersectin2_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-2
    smart00325
    Location:11871367
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    pfam15279
    Location:90182
    SOBP; Sine oculis-binding protein
    pfam16617
    Location:788875
    INTAP; Intersectin and clathrin adaptor AP2 binding region
    pfam16652
    Location:13851527
    PH_13; Pleckstrin homology domain
    cl25732
    Location:377727
    SMC_N; RecF/RecN/SMC N terminal domain
  9. NM_147152.3NP_671494.2  intersectin-2 isoform 2

    See identical proteins and their annotated locations for NP_671494.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2), also known as ITSN2-S1, has an alternate 3' coding region and 3' UTR compared to variant 1. The resulting protein (isoform 2) has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC009228, AF038189, AF182199, DA382952
    Consensus CDS
    CCDS46230.1
    UniProtKB/Swiss-Prot
    Q9NZM3
    Related
    ENSP00000384499.3, ENST00000406921.7
    Conserved Domains (13) summary
    smart00027
    Location:15107
    EH; Eps15 homology domain
    cd11988
    Location:759815
    SH3_Intersectin2_1; First Src homology 3 domain (or SH3A) of Intersectin-2
    cd11990
    Location:902953
    SH3_Intersectin2_2; Second Src homology 3 domain (or SH3B) of Intersectin-2
    cd11992
    Location:9851036
    SH3_Intersectin2_3; Third Src homology 3 domain (or SH3C) of Intersectin-2
    cd11994
    Location:10571115
    SH3_Intersectin2_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-2
    cd11996
    Location:11301183
    SH3_Intersectin2_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-2
    cd00052
    Location:248314
    EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
    pfam08496
    Location:692757
    Peptidase_S49_N; Peptidase family S49 N-terminal
    pfam13499
    Location:249306
    EF-hand_7; EF-hand domain pair
    pfam13868
    Location:387741
    TPH; Trichohyalin-plectin-homology domain
    pfam16617
    Location:815902
    INTAP; Intersectin and clathrin adaptor AP2 binding region
    cd16269
    Location:454465
    GBP_C; coiled coil [structural motif]
    cl20817
    Location:379484
    GBP_C; Guanylate-binding protein, C-terminal domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    24202864..24360538 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024452935.1XP_024308703.1  intersectin-2 isoform X5

    Conserved Domains (12) summary
    cd08375
    Location:15141648
    C2_Intersectin; C2 domain present in Intersectin
    smart00027
    Location:193
    EH; Eps15 homology domain
    cd11988
    Location:718774
    SH3_Intersectin2_1; First Src homology 3 domain (or SH3A) of Intersectin-2
    cd11990
    Location:861912
    SH3_Intersectin2_2; Second Src homology 3 domain (or SH3B) of Intersectin-2
    cd11992
    Location:944995
    SH3_Intersectin2_3; Third Src homology 3 domain (or SH3C) of Intersectin-2
    cd11994
    Location:10161074
    SH3_Intersectin2_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-2
    cd11996
    Location:10891142
    SH3_Intersectin2_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-2
    smart00325
    Location:11731353
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    pfam15279
    Location:76168
    SOBP; Sine oculis-binding protein
    pfam16617
    Location:774861
    INTAP; Intersectin and clathrin adaptor AP2 binding region
    pfam16652
    Location:13711513
    PH_13; Pleckstrin homology domain
    cl25732
    Location:363713
    SMC_N; RecF/RecN/SMC N terminal domain
  2. XM_024452933.1XP_024308701.1  intersectin-2 isoform X3

    Conserved Domains (12) summary
    cd08375
    Location:15421676
    C2_Intersectin; C2 domain present in Intersectin
    smart00027
    Location:15107
    EH; Eps15 homology domain
    cd11988
    Location:746802
    SH3_Intersectin2_1; First Src homology 3 domain (or SH3A) of Intersectin-2
    cd11990
    Location:889940
    SH3_Intersectin2_2; Second Src homology 3 domain (or SH3B) of Intersectin-2
    cd11992
    Location:9721023
    SH3_Intersectin2_3; Third Src homology 3 domain (or SH3C) of Intersectin-2
    cd11994
    Location:10441102
    SH3_Intersectin2_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-2
    cd11996
    Location:11171170
    SH3_Intersectin2_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-2
    smart00325
    Location:12011381
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    pfam15279
    Location:90182
    SOBP; Sine oculis-binding protein
    pfam16617
    Location:802889
    INTAP; Intersectin and clathrin adaptor AP2 binding region
    pfam16652
    Location:13991541
    PH_13; Pleckstrin homology domain
    cl26511
    Location:346743
    Neuromodulin_N; Gap junction protein N-terminal region
  3. XM_024452931.1XP_024308699.1  intersectin-2 isoform X1

    Conserved Domains (12) summary
    cd08375
    Location:15551689
    C2_Intersectin; C2 domain present in Intersectin
    smart00027
    Location:15107
    EH; Eps15 homology domain
    cd11988
    Location:759815
    SH3_Intersectin2_1; First Src homology 3 domain (or SH3A) of Intersectin-2
    cd11990
    Location:902953
    SH3_Intersectin2_2; Second Src homology 3 domain (or SH3B) of Intersectin-2
    cd11992
    Location:9851036
    SH3_Intersectin2_3; Third Src homology 3 domain (or SH3C) of Intersectin-2
    cd11994
    Location:10571115
    SH3_Intersectin2_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-2
    cd11996
    Location:11301183
    SH3_Intersectin2_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-2
    smart00325
    Location:12141394
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    pfam15279
    Location:90182
    SOBP; Sine oculis-binding protein
    pfam16617
    Location:815902
    INTAP; Intersectin and clathrin adaptor AP2 binding region
    pfam16652
    Location:14121554
    PH_13; Pleckstrin homology domain
    cl26511
    Location:346756
    Neuromodulin_N; Gap junction protein N-terminal region
  4. XM_024452932.1XP_024308700.1  intersectin-2 isoform X2

    Conserved Domains (12) summary
    cd08375
    Location:15411675
    C2_Intersectin; C2 domain present in Intersectin
    smart00027
    Location:193
    EH; Eps15 homology domain
    cd11988
    Location:745801
    SH3_Intersectin2_1; First Src homology 3 domain (or SH3A) of Intersectin-2
    cd11990
    Location:888939
    SH3_Intersectin2_2; Second Src homology 3 domain (or SH3B) of Intersectin-2
    cd11992
    Location:9711022
    SH3_Intersectin2_3; Third Src homology 3 domain (or SH3C) of Intersectin-2
    cd11994
    Location:10431101
    SH3_Intersectin2_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-2
    cd11996
    Location:11161169
    SH3_Intersectin2_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-2
    smart00325
    Location:12001380
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    pfam15279
    Location:76168
    SOBP; Sine oculis-binding protein
    pfam16617
    Location:801888
    INTAP; Intersectin and clathrin adaptor AP2 binding region
    pfam16652
    Location:13981540
    PH_13; Pleckstrin homology domain
    cl26511
    Location:332742
    Neuromodulin_N; Gap junction protein N-terminal region
  5. XM_024452930.1XP_024308698.1  intersectin-2 isoform X1

    Conserved Domains (12) summary
    cd08375
    Location:15551689
    C2_Intersectin; C2 domain present in Intersectin
    smart00027
    Location:15107
    EH; Eps15 homology domain
    cd11988
    Location:759815
    SH3_Intersectin2_1; First Src homology 3 domain (or SH3A) of Intersectin-2
    cd11990
    Location:902953
    SH3_Intersectin2_2; Second Src homology 3 domain (or SH3B) of Intersectin-2
    cd11992
    Location:9851036
    SH3_Intersectin2_3; Third Src homology 3 domain (or SH3C) of Intersectin-2
    cd11994
    Location:10571115
    SH3_Intersectin2_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-2
    cd11996
    Location:11301183
    SH3_Intersectin2_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-2
    smart00325
    Location:12141394
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    pfam15279
    Location:90182
    SOBP; Sine oculis-binding protein
    pfam16617
    Location:815902
    INTAP; Intersectin and clathrin adaptor AP2 binding region
    pfam16652
    Location:14121554
    PH_13; Pleckstrin homology domain
    cl26511
    Location:346756
    Neuromodulin_N; Gap junction protein N-terminal region
  6. XM_024452937.1XP_024308705.1  intersectin-2 isoform X7

    Conserved Domains (9) summary
    cd08375
    Location:787921
    C2_Intersectin; C2 domain present in Intersectin
    cd11990
    Location:134185
    SH3_Intersectin2_2; Second Src homology 3 domain (or SH3B) of Intersectin-2
    cd11992
    Location:217268
    SH3_Intersectin2_3; Third Src homology 3 domain (or SH3C) of Intersectin-2
    cd11994
    Location:289347
    SH3_Intersectin2_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-2
    cd11996
    Location:362415
    SH3_Intersectin2_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-2
    smart00325
    Location:446626
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    pfam16617
    Location:47134
    INTAP; Intersectin and clathrin adaptor AP2 binding region
    pfam16652
    Location:644786
    PH_13; Pleckstrin homology domain
    cl17036
    Location:1547
    SH3; Src Homology 3 domain superfamily
  7. XM_024452934.1XP_024308702.1  intersectin-2 isoform X4

    Conserved Domains (12) summary
    cd08375
    Location:15281662
    C2_Intersectin; C2 domain present in Intersectin
    smart00027
    Location:15107
    EH; Eps15 homology domain
    cd11988
    Location:732788
    SH3_Intersectin2_1; First Src homology 3 domain (or SH3A) of Intersectin-2
    cd11990
    Location:875926
    SH3_Intersectin2_2; Second Src homology 3 domain (or SH3B) of Intersectin-2
    cd11992
    Location:9581009
    SH3_Intersectin2_3; Third Src homology 3 domain (or SH3C) of Intersectin-2
    cd11994
    Location:10301088
    SH3_Intersectin2_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-2
    cd11996
    Location:11031156
    SH3_Intersectin2_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-2
    smart00325
    Location:11871367
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    pfam15279
    Location:90182
    SOBP; Sine oculis-binding protein
    pfam16617
    Location:788875
    INTAP; Intersectin and clathrin adaptor AP2 binding region
    pfam16652
    Location:13851527
    PH_13; Pleckstrin homology domain
    cl25732
    Location:377727
    SMC_N; RecF/RecN/SMC N terminal domain
  8. XM_024452936.1XP_024308704.1  intersectin-2 isoform X6

    Conserved Domains (9) summary
    smart00027
    Location:193
    EH; Eps15 homology domain
    cd11988
    Location:745801
    SH3_Intersectin2_1; First Src homology 3 domain (or SH3A) of Intersectin-2
    cd11990
    Location:888939
    SH3_Intersectin2_2; Second Src homology 3 domain (or SH3B) of Intersectin-2
    cd11992
    Location:9711022
    SH3_Intersectin2_3; Third Src homology 3 domain (or SH3C) of Intersectin-2
    cd11994
    Location:10431101
    SH3_Intersectin2_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-2
    cd11996
    Location:11161169
    SH3_Intersectin2_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-2
    pfam15279
    Location:76168
    SOBP; Sine oculis-binding protein
    pfam16617
    Location:801888
    INTAP; Intersectin and clathrin adaptor AP2 binding region
    cl26511
    Location:332742
    Neuromodulin_N; Gap junction protein N-terminal region

RNA

  1. XR_002959302.1 RNA Sequence

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