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EIF2AK4 eukaryotic translation initiation factor 2 alpha kinase 4 [ Bubalus bubalis (water buffalo) ]

Gene ID: 102414081, updated on 10-Mar-2024

Summary

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Gene symbol
EIF2AK4
Gene description
eukaryotic translation initiation factor 2 alpha kinase 4
See related
EnsemblRapid:ENSBALG00030037578
Gene type
protein coding
RefSeq status
MODEL
Organism
Bubalus bubalis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bubalus
Orthologs
human mouse all
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Genomic context

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See EIF2AK4 in Genome Data Viewer
Location:
chromosome: 11
Exon count:
39
Annotation release Status Assembly Chr Location
103 current NDDB_SH_1 (GCF_019923935.1) 11 NC_059167.1 (67600373..67698442, complement)
102 previous assembly NDDB_DH_1 (GCF_019923925.1) 11 NC_058353.1 (66927978..67026039, complement)

Chromosome 11 - NC_059167.1Genomic Context describing neighboring genes Neighboring gene Bcl2 modifying factor Neighboring gene signal recognition particle 14 Neighboring gene U6 spliceosomal RNA Neighboring gene G protein-coupled receptor 176 Neighboring gene fibrous sheath interacting protein 1 Neighboring gene thrombospondin 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables eukaryotic translation initiation factor 2alpha kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA damage checkpoint signaling IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of translational initiation by eIF2 alpha phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
eIF-2-alpha kinase GCN2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Bubalus bubalis Annotation Release 103 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference NDDB_SH_1 Primary Assembly

Genomic

  1. NC_059167.1 Reference NDDB_SH_1 Primary Assembly

    Range
    67600373..67698442 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006073022.4 → XP_006073084.3  eIF-2-alpha kinase GCN2 isoform X1

    Related
    ENSBALP00030069654.1, ENSBALT00030104235.1
    Conserved Domains (5) summary
    smart00591
    Location:26 → 137
    RWD; domain in RING finger and WD repeat containing proteins and DEXDc-like helicases subfamily related to the UBCc domain
    PLN02972
    Location:1051 → 1491
    PLN02972; Histidyl-tRNA synthetase
    cd14012
    Location:299 → 538
    PK_eIF2AK_GCN2_rpt1; Pseudokinase domain, repeat 1, of eukaryotic translation Initiation Factor 2-Alpha Kinase 4 or General Control Non-derepressible-2
    cd14046
    Location:583 → 999
    STKc_EIF2AK4_GCN2_rpt2; Catalytic domain, repeat 2, of the Serine/Threonine kinase, eukaryotic translation Initiation Factor 2-Alpha Kinase 4 or General Control Non-derepressible-2
    cl00266
    Location:1397 → 1641
    HGTP_anticodon; HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for ...

  2. XM_006073025.4 → XP_006073087.3  eIF-2-alpha kinase GCN2 isoform X2

    Related
    ENSBALP00030069503.1, ENSBALT00030104041.1
    Conserved Domains (4) summary
    smart00591
    Location:26 → 137
    RWD; domain in RING finger and WD repeat containing proteins and DEXDc-like helicases subfamily related to the UBCc domain
    PLN02972
    Location:1051 → 1491
    PLN02972; Histidyl-tRNA synthetase
    cd14012
    Location:299 → 538
    PK_eIF2AK_GCN2_rpt1; Pseudokinase domain, repeat 1, of eukaryotic translation Initiation Factor 2-Alpha Kinase 4 or General Control Non-derepressible-2
    cd14046
    Location:583 → 999
    STKc_EIF2AK4_GCN2_rpt2; Catalytic domain, repeat 2, of the Serine/Threonine kinase, eukaryotic translation Initiation Factor 2-Alpha Kinase 4 or General Control Non-derepressible-2

RNA

  1. XR_328826.4 RNA Sequence

    Related
    ENSBALT00030103974.1
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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