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ACTN1 actinin alpha 1 [ Bos mutus (wild yak) ]

Gene ID: 102287647, updated on 10-Mar-2024

Summary

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Gene symbol
ACTN1
Gene description
actinin alpha 1
Locus tag
M91_10586
See related
Ensembl:ENSBMUG00000012867
Gene type
protein coding
RefSeq status
MODEL
Organism
Bos mutus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: Un
Exon count:
23
Annotation release Status Assembly Chr Location
101 current BosGru_v2.0 (GCF_000298355.1) Unplaced Scaffold NW_005395103.1 (1244483..1344114, complement)

NW_005395103.1Genomic Context describing neighboring genes Neighboring gene ZFP36 ring finger protein like 1 Neighboring gene GTP-binding nuclear protein Ran pseudogene Neighboring gene DDB1 and CUL4 associated factor 5 Neighboring gene exonuclease 3'-5' domain containing 2

Genomic regions, transcripts, and products

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Genomic Sequence:
NW_005395103.1 Unplaced Scaffold Reference BosGru_v2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables actin filament binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in actin cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in muscle cell development IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in Z disc IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cell junction IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cortical actin cytoskeleton IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in stress fiber IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
alpha-actinin-1
Names
Alpha-actinin-1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Bos mutus Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference BosGru_v2.0 Primary Assembly

Genomic

  1. NW_005395103.1 Reference BosGru_v2.0 Primary Assembly

    Range
    1244483..1344114 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005905735.2 → XP_005905797.1  alpha-actinin-1 isoform X3

    See identical proteins and their annotated locations for XP_005905797.1

    UniProtKB/TrEMBL
    L8HXT3
    Related
    ENSBMUP00000016996.1, ENSBMUT00000019662.1
    Conserved Domains (6) summary
    COG5126
    Location:743 → 847
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
    cd00176
    Location:395 → 622
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00435
    Location:634 → 733
    Spectrin; Spectrin repeat
    pfam08726
    Location:817 → 883
    EFhand_Ca_insen; Ca2+ insensitive EF hand
    cd21214
    Location:28 → 132
    CH_ACTN_rpt1; first calponin homology (CH) domain found in the alpha-actinin family
    cd21216
    Location:136 → 250
    CH_ACTN_rpt2; second calponin homology (CH) domain found in the alpha-actinin family

  2. XM_005905734.2 → XP_005905796.1  alpha-actinin-1 isoform X2

    See identical proteins and their annotated locations for XP_005905796.1

    UniProtKB/TrEMBL
    L8HXT3
    Related
    ENSBMUP00000016990.1, ENSBMUT00000019656.1
    Conserved Domains (6) summary
    cd00051
    Location:750 → 817
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:395 → 622
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00435
    Location:634 → 733
    Spectrin; Spectrin repeat
    pfam08726
    Location:822 → 888
    EFhand_Ca_insen; Ca2+ insensitive EF hand
    cd21214
    Location:28 → 132
    CH_ACTN_rpt1; first calponin homology (CH) domain found in the alpha-actinin family
    cd21216
    Location:136 → 250
    CH_ACTN_rpt2; second calponin homology (CH) domain found in the alpha-actinin family

  3. XM_005905733.2 → XP_005905795.1  alpha-actinin-1 isoform X1

    See identical proteins and their annotated locations for XP_005905795.1

    UniProtKB/TrEMBL
    A0A6B0S8L6, L8HXT3
    Related
    ENSBMUP00000016981.1, ENSBMUT00000019647.1
    Conserved Domains (6) summary
    cd00051
    Location:750 → 839
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:395 → 622
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00435
    Location:634 → 733
    Spectrin; Spectrin repeat
    pfam08726
    Location:844 → 910
    EFhand_Ca_insen; Ca2+ insensitive EF hand
    cd21214
    Location:28 → 132
    CH_ACTN_rpt1; first calponin homology (CH) domain found in the alpha-actinin family
    cd21216
    Location:136 → 250
    CH_ACTN_rpt2; second calponin homology (CH) domain found in the alpha-actinin family

  4. XM_005905736.2 → XP_005905798.1  alpha-actinin-1 isoform X4

    UniProtKB/TrEMBL
    L8HXT3
    Conserved Domains (7) summary
    smart00033
    Location:3 → 68
    CH; Calponin homology domain
    cd00014
    Location:80 → 184
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cd00051
    Location:685 → 747
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:330 → 557
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00435
    Location:569 → 668
    Spectrin; Spectrin repeat
    pfam08726
    Location:752 → 818
    EFhand_Ca_insen; Ca2+ insensitive EF hand
    pfam13499
    Location:687 → 746
    EF-hand_7; EF-hand domain pair
Nucleotide Protein
Heading Accession and Version

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