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DUSP8 dual specificity phosphatase 8 [ Macaca fascicularis (crab-eating macaque) ]

Gene ID: 102121929, updated on 12-Jun-2024

Summary

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Gene symbol
DUSP8
Gene description
dual specificity phosphatase 8
See related
Ensembl:ENSMFAG00000002727
Gene type
protein coding
RefSeq status
MODEL
Organism
Macaca fascicularis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Orthologs
human mouse all
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Genomic context

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See DUSP8 in Genome Data Viewer
Location:
chromosome: 14
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_05 current T2T-MFA8v1.0 (GCF_037993035.1) 14 NC_088388.1 (1477076..1493915, complement)
102 previous assembly MFA1912RKSv2 (GCF_012559485.2) 14 NC_052268.1 (124075814..124094616)

Chromosome 14 - NC_088388.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC135966973 Neighboring gene MOB kinase activator 2 Neighboring gene uncharacterized LOC102121533 Neighboring gene antigen LPMC-61-like Neighboring gene putative uncharacterized protein DDB_G0291608 Neighboring gene uncharacterized LOC102123952

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables MAP kinase tyrosine phosphatase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables MAP kinase tyrosine/serine/threonine phosphatase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein tyrosine/threonine phosphatase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of MAPK cascade IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein dephosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
dual specificity protein phosphatase 8

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_037993035.1-RS_2024_05

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference T2T-MFA8v1.0

Genomic

  1. NC_088388.1 Reference T2T-MFA8v1.0

    Range
    1477076..1493915 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_045372392.2 → XP_045228327.1  dual specificity protein phosphatase 8 isoform X2

    UniProtKB/TrEMBL
    A0A2K5WQD6

  2. XM_045372390.2 → XP_045228325.1  dual specificity protein phosphatase 8 isoform X1

    UniProtKB/TrEMBL
    A0A2K5WQD6
    Conserved Domains (2) summary
    cd01446
    Location:10 → 137
    DSP_MapKP; N-terminal regulatory rhodanese domain of dual specificity phosphatases (DSP), such as Mapk Phosphatase. This domain is believed to determine substrate specificity by binding the substrate, such as ERK2, and activating the C-terminal catalytic domain by ...
    cd14645
    Location:150 → 300
    DSP_DUSP8; dual specificity phosphatase domain of dual specificity protein phosphatase 8
Nucleotide Protein
Heading Accession and Version

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