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Lrp8 LDL receptor related protein 8 [ Mesocricetus auratus (golden hamster) ]

Gene ID: 101836610, updated on 8-Mar-2024

Summary

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Gene symbol
Lrp8
Gene description
LDL receptor related protein 8
See related
EnsemblRapid:ENSMAUG00000021959
Gene type
protein coding
RefSeq status
MODEL
Organism
Mesocricetus auratus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Cricetidae; Cricetinae; Mesocricetus
Orthologs
human mouse all
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Genomic context

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See Lrp8 in Genome Data Viewer
Location:
chromosome: Un
Exon count:
22
Annotation release Status Assembly Chr Location
103 current BCM_Maur_2.0 (GCF_017639785.1) Unplaced Scaffold NW_024429197.1 (31297543..31371129, complement)
102 previous assembly MesAur1.0 (GCF_000349665.1) Unplaced Scaffold NW_004801635.1 (11758167..11828727, complement)

NW_024429197.1Genomic Context describing neighboring genes Neighboring gene CXXC motif containing zinc binding protein Neighboring gene mago homolog, exon junction complex subunit Neighboring gene uncharacterized LOC121144109 Neighboring gene DMRT like family B with proline rich C-terminal 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. De novo assembly, annotation, and characterization of the whole brain transcriptome of male and female Syrian hamsters. McCann KE, et al. Sci Rep, 2017 Jan 10. PMID 28071753, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
low-density lipoprotein receptor-related protein 8

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Mesocricetus auratus Annotation Release 103 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference BCM_Maur_2.0 Primary Assembly

Genomic

  1. NW_024429197.1 Reference BCM_Maur_2.0 Primary Assembly

    Range
    31297543..31371129 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_013114955.3 → XP_012970409.1  low-density lipoprotein receptor-related protein 8 isoform X8

    UniProtKB/TrEMBL
    A0A1U8C493
    Conserved Domains (7) summary
    smart00192
    Location:82 → 114
    LDLa; Low-density lipoprotein receptor domain class A
    smart00135
    Location:527 → 568
    LY; Low-density lipoprotein-receptor YWTD domain
    smart00179
    Location:413 → 443
    EGF_CA; Calcium-binding EGF-like domain
    cd00112
    Location:44 → 78
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    pfam00058
    Location:589 → 629
    Ldl_recept_b; Low-density lipoprotein receptor repeat class B
    pfam14670
    Location:377 → 411
    FXa_inhibition; Coagulation Factor Xa inhibitory site
    cl00104
    Location:333 → 369
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

  2. XM_005072148.4 → XP_005072205.1  low-density lipoprotein receptor-related protein 8 isoform X2

    UniProtKB/TrEMBL
    A0A1U7QQ11
    Conserved Domains (7) summary
    smart00192
    Location:82 → 114
    LDLa; Low-density lipoprotein receptor domain class A
    smart00135
    Location:526 → 567
    LY; Low-density lipoprotein-receptor YWTD domain
    smart00179
    Location:412 → 442
    EGF_CA; Calcium-binding EGF-like domain
    cd00112
    Location:44 → 78
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    pfam00058
    Location:588 → 628
    Ldl_recept_b; Low-density lipoprotein receptor repeat class B
    pfam14670
    Location:376 → 410
    FXa_inhibition; Coagulation Factor Xa inhibitory site
    cl00104
    Location:332 → 368
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

  3. XM_013114949.3 → XP_012970403.1  low-density lipoprotein receptor-related protein 8 isoform X1

    UniProtKB/TrEMBL
    A0A1U8C3Q6
    Conserved Domains (7) summary
    smart00192
    Location:82 → 114
    LDLa; Low-density lipoprotein receptor domain class A
    smart00135
    Location:527 → 568
    LY; Low-density lipoprotein-receptor YWTD domain
    smart00179
    Location:413 → 443
    EGF_CA; Calcium-binding EGF-like domain
    cd00112
    Location:44 → 78
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    pfam00058
    Location:589 → 629
    Ldl_recept_b; Low-density lipoprotein receptor repeat class B
    pfam14670
    Location:377 → 411
    FXa_inhibition; Coagulation Factor Xa inhibitory site
    cl00104
    Location:333 → 369
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

  4. XM_040757018.1 → XP_040612952.1  low-density lipoprotein receptor-related protein 8 isoform X4

    UniProtKB/TrEMBL
    A0A3Q0CTL0
    Conserved Domains (4) summary
    smart00192
    Location:82 → 114
    LDLa; Low-density lipoprotein receptor domain class A
    smart00135
    Location:498 → 539
    LY; Low-density lipoprotein-receptor YWTD domain
    smart00179
    Location:384 → 414
    EGF_CA; Calcium-binding EGF-like domain
    cd00112
    Location:44 → 78
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

  5. XM_013114956.3 → XP_012970410.1  low-density lipoprotein receptor-related protein 8 isoform X9

    UniProtKB/TrEMBL
    A0A1U8BWC4, A0A3Q0CTL0
    Related
    ENSMAUP00000043076.1, ENSMAUT00000074711.1
    Conserved Domains (6) summary
    smart00192
    Location:82 → 114
    LDLa; Low-density lipoprotein receptor domain class A
    smart00135
    Location:446 → 487
    LY; Low-density lipoprotein-receptor YWTD domain
    smart00179
    Location:332 → 362
    EGF_CA; Calcium-binding EGF-like domain
    cd00112
    Location:44 → 78
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    pfam00058
    Location:508 → 548
    Ldl_recept_b; Low-density lipoprotein receptor repeat class B
    pfam14670
    Location:653 → 690
    FXa_inhibition; Coagulation Factor Xa inhibitory site

  6. XM_013114952.3 → XP_012970406.1  low-density lipoprotein receptor-related protein 8 isoform X5

    UniProtKB/TrEMBL
    A0A1U8BT15, A0A3Q0CTL0
    Conserved Domains (6) summary
    smart00192
    Location:82 → 114
    LDLa; Low-density lipoprotein receptor domain class A
    smart00135
    Location:486 → 527
    LY; Low-density lipoprotein-receptor YWTD domain
    smart00179
    Location:372 → 402
    EGF_CA; Calcium-binding EGF-like domain
    cd00112
    Location:44 → 78
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    pfam00058
    Location:548 → 588
    Ldl_recept_b; Low-density lipoprotein receptor repeat class B
    pfam14670
    Location:336 → 370
    FXa_inhibition; Coagulation Factor Xa inhibitory site

  7. XM_013114951.3 → XP_012970405.1  low-density lipoprotein receptor-related protein 8 isoform X3

    UniProtKB/TrEMBL
    A0A1U8BWB8, A0A3Q0CTL0
    Related
    ENSMAUP00000056440.1, ENSMAUT00000042750.1
    Conserved Domains (6) summary
    smart00192
    Location:82 → 114
    LDLa; Low-density lipoprotein receptor domain class A
    smart00135
    Location:499 → 540
    LY; Low-density lipoprotein-receptor YWTD domain
    smart00179
    Location:385 → 415
    EGF_CA; Calcium-binding EGF-like domain
    cd00112
    Location:44 → 78
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    pfam00058
    Location:561 → 601
    Ldl_recept_b; Low-density lipoprotein receptor repeat class B
    pfam14670
    Location:349 → 383
    FXa_inhibition; Coagulation Factor Xa inhibitory site

  8. XM_013114954.3 → XP_012970408.1  low-density lipoprotein receptor-related protein 8 isoform X7

    UniProtKB/TrEMBL
    A0A1U8C3R1
    Related
    ENSMAUP00000046416.1, ENSMAUT00000070172.1
    Conserved Domains (7) summary
    smart00192
    Location:82 → 114
    LDLa; Low-density lipoprotein receptor domain class A
    smart00135
    Location:527 → 568
    LY; Low-density lipoprotein-receptor YWTD domain
    smart00179
    Location:413 → 443
    EGF_CA; Calcium-binding EGF-like domain
    cd00112
    Location:44 → 78
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    pfam00058
    Location:589 → 629
    Ldl_recept_b; Low-density lipoprotein receptor repeat class B
    pfam14670
    Location:377 → 411
    FXa_inhibition; Coagulation Factor Xa inhibitory site
    cl00104
    Location:333 → 369
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

  9. XM_013114957.3 → XP_012970411.1  low-density lipoprotein receptor-related protein 8 isoform X12

    UniProtKB/TrEMBL
    A0A1U8BT21, A0A3Q0CTL0
    Conserved Domains (7) summary
    smart00192
    Location:82 → 114
    LDLa; Low-density lipoprotein receptor domain class A
    smart00135
    Location:399 → 440
    LY; Low-density lipoprotein-receptor YWTD domain
    smart00179
    Location:285 → 315
    EGF_CA; Calcium-binding EGF-like domain
    cd00112
    Location:44 → 78
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    pfam00058
    Location:461 → 501
    Ldl_recept_b; Low-density lipoprotein receptor repeat class B
    pfam14670
    Location:249 → 283
    FXa_inhibition; Coagulation Factor Xa inhibitory site
    cl00104
    Location:205 → 241
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

  10. XM_005072151.4 → XP_005072208.1  low-density lipoprotein receptor-related protein 8 isoform X11

    UniProtKB/TrEMBL
    A0A1U7QH75, A0A3Q0CTL0
    Conserved Domains (7) summary
    smart00192
    Location:82 → 114
    LDLa; Low-density lipoprotein receptor domain class A
    smart00135
    Location:400 → 441
    LY; Low-density lipoprotein-receptor YWTD domain
    smart00179
    Location:286 → 316
    EGF_CA; Calcium-binding EGF-like domain
    cd00112
    Location:44 → 78
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    pfam00058
    Location:462 → 502
    Ldl_recept_b; Low-density lipoprotein receptor repeat class B
    pfam14670
    Location:250 → 284
    FXa_inhibition; Coagulation Factor Xa inhibitory site
    cl00104
    Location:206 → 242
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

  11. XM_013114953.3 → XP_012970407.1  low-density lipoprotein receptor-related protein 8 isoform X6

    UniProtKB/TrEMBL
    A0A1U8BT17, A0A3Q0CTL0
    Conserved Domains (6) summary
    smart00192
    Location:82 → 114
    LDLa; Low-density lipoprotein receptor domain class A
    smart00135
    Location:485 → 526
    LY; Low-density lipoprotein-receptor YWTD domain
    smart00179
    Location:371 → 401
    EGF_CA; Calcium-binding EGF-like domain
    cd00112
    Location:44 → 78
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    pfam00058
    Location:547 → 587
    Ldl_recept_b; Low-density lipoprotein receptor repeat class B
    pfam14670
    Location:335 → 369
    FXa_inhibition; Coagulation Factor Xa inhibitory site

  12. XM_040757019.1 → XP_040612953.1  low-density lipoprotein receptor-related protein 8 isoform X13

    UniProtKB/TrEMBL
    A0A3Q0CTL0
    Conserved Domains (4) summary
    smart00192
    Location:82 → 114
    LDLa; Low-density lipoprotein receptor domain class A
    smart00135
    Location:319 → 360
    LY; Low-density lipoprotein-receptor YWTD domain
    smart00179
    Location:205 → 235
    EGF_CA; Calcium-binding EGF-like domain
    cd00112
    Location:44 → 78
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

  13. XM_005072150.4 → XP_005072207.1  low-density lipoprotein receptor-related protein 8 isoform X10

    UniProtKB/TrEMBL
    A0A1U7QSN4, A0A3Q0CTL0
    Related
    ENSMAUP00000041188.1, ENSMAUT00000064763.1
    Conserved Domains (6) summary
    smart00192
    Location:82 → 114
    LDLa; Low-density lipoprotein receptor domain class A
    smart00135
    Location:485 → 526
    LY; Low-density lipoprotein-receptor YWTD domain
    smart00179
    Location:371 → 401
    EGF_CA; Calcium-binding EGF-like domain
    cd00112
    Location:44 → 78
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    pfam00058
    Location:547 → 587
    Ldl_recept_b; Low-density lipoprotein receptor repeat class B
    pfam14670
    Location:335 → 369
    FXa_inhibition; Coagulation Factor Xa inhibitory site

  14. XM_013114958.3 → XP_012970412.1  low-density lipoprotein receptor-related protein 8 isoform X15

    UniProtKB/TrEMBL
    A0A1U8BT23, A0A3Q0CTL0
    Conserved Domains (6) summary
    smart00192
    Location:82 → 114
    LDLa; Low-density lipoprotein receptor domain class A
    smart00135
    Location:358 → 399
    LY; Low-density lipoprotein-receptor YWTD domain
    smart00179
    Location:244 → 274
    EGF_CA; Calcium-binding EGF-like domain
    cd00112
    Location:44 → 78
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    pfam00058
    Location:420 → 460
    Ldl_recept_b; Low-density lipoprotein receptor repeat class B
    pfam14670
    Location:208 → 242
    FXa_inhibition; Coagulation Factor Xa inhibitory site

  15. XM_040757020.1 → XP_040612954.1  low-density lipoprotein receptor-related protein 8 isoform X14

    UniProtKB/TrEMBL
    A0A3Q0CTL0
    Related
    ENSMAUP00000053925.1, ENSMAUT00000035307.1
    Conserved Domains (4) summary
    smart00192
    Location:82 → 114
    LDLa; Low-density lipoprotein receptor domain class A
    smart00135
    Location:371 → 412
    LY; Low-density lipoprotein-receptor YWTD domain
    smart00179
    Location:257 → 287
    EGF_CA; Calcium-binding EGF-like domain
    cd00112
    Location:44 → 78
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

  16. XM_040757021.1 → XP_040612955.1  low-density lipoprotein receptor-related protein 8 isoform X16

    Conserved Domains (2) summary
    smart00135
    Location:160 → 201
    LY; Low-density lipoprotein-receptor YWTD domain
    smart00179
    Location:46 → 85
    EGF_CA; Calcium-binding EGF-like domain
Nucleotide Protein
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