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ARHGEF28 Rho guanine nucleotide exchange factor 28 [ Condylura cristata (star-nosed mole) ]

Gene ID: 101630803, updated on 8-Mar-2024

Summary

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Gene symbol
ARHGEF28
Gene description
Rho guanine nucleotide exchange factor 28
Gene type
protein coding
RefSeq status
MODEL
Organism
Condylura cristata
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Eulipotyphla; Talpidae; Condylura
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: Un
Exon count:
37
Annotation release Status Assembly Chr Location
101 current ConCri1.0 (GCF_000260355.1) Unplaced Scaffold NW_004567108.1 (37680703..37933652, complement)

NW_004567108.1Genomic Context describing neighboring genes Neighboring gene hexosaminidase subunit beta Neighboring gene ectodermal-neural cortex 1 Neighboring gene ankyrin repeat family A member 2 Neighboring gene UTP15 small subunit processome component

Genomic regions, transcripts, and products

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Genomic Sequence:
NW_004567108.1 Unplaced Scaffold Reference ConCri1.0

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell morphogenesis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of Rho protein signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
rho guanine nucleotide exchange factor 28

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Condylura cristata Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ConCri1.0

Genomic

  1. NW_004567108.1 Reference ConCri1.0

    Range
    37680703..37933652 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_012721846.1 → XP_012577300.1  rho guanine nucleotide exchange factor 28 isoform X2

    Conserved Domains (8) summary
    cd00029
    Location:654 → 699
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd00160
    Location:851 → 1043
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00204
    Location:162 → 218
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd14680
    Location:1088 → 1188
    PH_p190RhoGEF; Rho guanine nucleotide exchange factor Pleckstrin homology domain
    pfam00169
    Location:1124 → 1189
    PH; PH domain
    pfam12796
    Location:158 → 216
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:162 → 197
    ANK; ANK repeat [structural motif]
    cl01482
    Location:1388 → 1520
    CpxP_like; CpxP component of the bacterial Cpx-two-component system and related proteins

  2. XM_012721845.1 → XP_012577299.1  rho guanine nucleotide exchange factor 28 isoform X1

    Conserved Domains (8) summary
    cd00029
    Location:680 → 725
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd00160
    Location:877 → 1069
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00204
    Location:162 → 218
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd14680
    Location:1114 → 1214
    PH_p190RhoGEF; Rho guanine nucleotide exchange factor Pleckstrin homology domain
    pfam00169
    Location:1150 → 1215
    PH; PH domain
    pfam12796
    Location:158 → 216
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:162 → 197
    ANK; ANK repeat [structural motif]
    cl01482
    Location:1414 → 1546
    CpxP_like; CpxP component of the bacterial Cpx-two-component system and related proteins

  3. XM_012721847.1 → XP_012577301.1  rho guanine nucleotide exchange factor 28 isoform X3

    Conserved Domains (9) summary
    cd00029
    Location:582 → 627
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd00160
    Location:779 → 971
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00204
    Location:64 → 120
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd14680
    Location:1016 → 1116
    PH_p190RhoGEF; Rho guanine nucleotide exchange factor Pleckstrin homology domain
    pfam00169
    Location:1052 → 1117
    PH; PH domain
    pfam02601
    Location:1407 → 1451
    Exonuc_VII_L; Exonuclease VII, large subunit
    pfam12796
    Location:66 → 118
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:64 → 99
    ANK; ANK repeat [structural motif]
    cl01482
    Location:1316 → 1448
    CpxP_like; CpxP component of the bacterial Cpx-two-component system and related proteins
Nucleotide Protein
Heading Accession and Version

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