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PREX1 phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1 [ Orcinus orca (killer whale) ]

Gene ID: 101283620, updated on 8-Mar-2024

Summary

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Gene symbol
PREX1
Gene description
phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1
See related
EnsemblRapid:ENSOORG00010006343
Gene type
protein coding
RefSeq status
MODEL
Organism
Orcinus orca
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti; Delphinidae; Orcinus
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 16
Exon count:
42
Annotation release Status Assembly Chr Location
RS_2023_02 current mOrcOrc1.1 (GCF_937001465.1) 16 NC_064574.1 (13232854..13434502)

Chromosome 16 - NC_064574.1Genomic Context describing neighboring genes Neighboring gene transfer RNA arginine (anticodon UCU) Neighboring gene ADP ribosylation factor guanine nucleotide exchange factor 2 Neighboring gene 60S ribosomal protein L31-like Neighboring gene ADP-ribosylation factor 1-like Neighboring gene uncharacterized LOC125961382 Neighboring gene uncharacterized LOC117197782 Neighboring gene uncharacterized LOC117202500

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_064574.1 Chromosome 16 Reference mOrcOrc1.1 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_937001465.1-RS_2023_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mOrcOrc1.1 Primary Assembly

Genomic

  1. NC_064574.1 Reference mOrcOrc1.1 Primary Assembly

    Range
    13232854..13434502
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_012537823.3 → XP_012393277.1  phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein isoform X1

    Related
    ENSOORP00010007620.1, ENSOORT00010009203.1
    Conserved Domains (7) summary
    cd00136
    Location:719 → 771
    PDZ; PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. ...
    cd00992
    Location:625 → 701
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd04440
    Location:504 → 596
    DEP_2_P-Rex; DEP (Dishevelled, Egl-10, and Pleckstrin) domain 2 found in P-Rex-like proteins. The P-Rex family is the guanine-nucleotide exchange factor (GEF) for the small GTPase Rac that contains an N-terminal RhoGEF domain, two DEP and PDZ domains. Rac-GEF ...
    cd01224
    Location:242 → 394
    PH_Collybistin_ASEF; Collybistin/APC-stimulated guanine nucleotide exchange factor pleckstrin homology (PH) domain
    pfam00169
    Location:281 → 387
    PH; PH domain
    pfam00621
    Location:51 → 237
    RhoGEF; RhoGEF domain
    cl02442
    Location:412 → 492
    DEP; DEP domain, named after Dishevelled, Egl-10, and Pleckstrin, where this domain was first discovered. The function of this domain is still not clear, but it is believed to be important for the membrane association of the signaling proteins in which it is ...

  2. XM_049699089.1 → XP_049555046.1  phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein isoform X2

  3. XM_033411142.1 → XP_033267033.1  phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein isoform X3

    Conserved Domains (5) summary
    cd00136
    Location:441 → 493
    PDZ; PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. ...
    cd00992
    Location:347 → 423
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd04440
    Location:226 → 318
    DEP_2_P-Rex; DEP (Dishevelled, Egl-10, and Pleckstrin) domain 2 found in P-Rex-like proteins. The P-Rex family is the guanine-nucleotide exchange factor (GEF) for the small GTPase Rac that contains an N-terminal RhoGEF domain, two DEP and PDZ domains. Rac-GEF ...
    cl02442
    Location:134 → 214
    DEP; DEP domain, named after Dishevelled, Egl-10, and Pleckstrin, where this domain was first discovered. The function of this domain is still not clear, but it is believed to be important for the membrane association of the signaling proteins in which it is ...
    cl17171
    Location:35 → 116
    PH-like; Pleckstrin homology-like domain
Nucleotide Protein
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